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Entry version 31 (16 Oct 2019)
Sequence version 1 (16 Apr 2014)
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Protein

Transcription-repair-coupling factor

Gene

mfd

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi676 – 683ATPUniRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Helicase, Hydrolase
Biological processDNA damage, DNA repair
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MTBH37RV:G185E-5179-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription-repair-coupling factorUniRule annotation (EC:3.6.4.-UniRule annotation)
Short name:
TRCFUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mfdUniRule annotation
Ordered Locus Names:Rv1020
ORF Names:MTCY10G2.29c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83332 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001584 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

Organism-specific databases

Mycobacterium tuberculosis strain H37Rv genome database

More...
TubercuListi
Rv1020

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001021701 – 1234Transcription-repair-coupling factorAdd BLAST1234

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P9WMQ5

PRoteomics IDEntifications database

More...
PRIDEi
P9WMQ5

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the RNA polymerase subunit beta (RpoB).

1 Publication

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P9WMQ5, 1 interactor

STRING: functional protein association networks

More...
STRINGi
83332.Rv1020

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P9WMQ5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini663 – 824Helicase ATP-bindingUniRule annotationAdd BLAST162
Domaini842 – 999Helicase C-terminalUniRule annotationAdd BLAST158

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi777 – 780DEEQ box4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the UvrB family.UniRule annotation
In the C-terminal section; belongs to the helicase family. RecG subfamily.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4108JA2 Bacteria
COG1197 LUCA

KEGG Orthology (KO)

More...
KOi
K03723

Identification of Orthologs from Complete Genome Data

More...
OMAi
KRGQPGD

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P9WMQ5

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.840, 1 hit
3.90.1150.50, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00969 TRCF, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036101 CarD-like/TRCF_dom_sf
IPR003711 CarD-like/TRCF_domain
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR004576 Mfd
IPR027417 P-loop_NTPase
IPR037235 TRCF-like_C
IPR005118 TRCF_C
IPR041471 UvrB_inter

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02559 CarD_CdnL_TRCF, 1 hit
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
PF03461 TRCF, 1 hit
PF17757 UvrB_inter, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01058 CarD_TRCF, 1 hit
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00982 TRCF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF141259 SSF141259, 1 hit
SSF143517 SSF143517, 1 hit
SSF52540 SSF52540, 4 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00580 mfd, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P9WMQ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTAPGPACSD TPIAGLVELA LSAPTFQQLM QRAGGRPDEL TLIAPASARL
60 70 80 90 100
LVASALARQG PLLVVTATGR EADDLAAELR GVFGDAVALL PSWETLPHER
110 120 130 140 150
LSPGVDTVGT RLMALRRLAH PDDAQLGPPL GVVVTSVRSL LQPMTPQLGM
160 170 180 190 200
MEPLTLTVGD ESPFDGVVAR LVELAYTRVD MVGRRGEFAV RGGILDIFAP
210 220 230 240 250
TAEHPVRVEF WGDEITEMRM FSVADQRSIP EIDIHTLVAF ACRELLLSED
260 270 280 290 300
VRARAAQLAA RHPAAESTVT GSASDMLAKL AEGIAVDGME AVLPVLWSDG
310 320 330 340 350
HALLTDQLPD GTPVLVCDPE KVRTRAADLI RTGREFLEAS WSVAALGTAE
360 370 380 390 400
NQAPVDVEQL GGSGFVELDQ VRAAAARTGH PWWTLSQLSD ESAIELDVRA
410 420 430 440 450
APSARGHQRD IDEIFAMLRA HIATGGYAAL VAPGTGTAHR VVERLSESDT
460 470 480 490 500
PAGMLDPGQA PKPGVVGVLQ GPLRDGVIIP GANLVVITET DLTGSRVSAA
510 520 530 540 550
EGKRLAAKRR NIVDPLALTA GDLVVHDQHG IGRFVEMVER TVGGARREYL
560 570 580 590 600
VLEYASAKRG GGAKNTDKLY VPMDSLDQLS RYVGGQAPAL SRLGGSDWAN
610 620 630 640 650
TKTKARRAVR EIAGELVSLY AKRQASPGHA FSPDTPWQAE LEDAFGFTET
660 670 680 690 700
VDQLTAIEEV KADMEKPIPM DRVICGDVGY GKTEIAVRAA FKAVQDGKQV
710 720 730 740 750
AVLVPTTLLA DQHLQTFGER MSGFPVTIKG LSRFTDAAES RAVIDGLADG
760 770 780 790 800
SVDIVIGTHR LLQTGVRWKD LGLVVVDEEQ RFGVEHKEHI KSLRTHVDVL
810 820 830 840 850
TMSATPIPRT LEMSLAGIRE MSTILTPPEE RYPVLTYVGP HDDKQIAAAL
860 870 880 890 900
RRELLRDGQA FYVHNRVSSI DAAAARVREL VPEARVVVAH GQMPEDLLET
910 920 930 940 950
TVQRFWNREH DILVCTTIVE TGLDISNANT LIVERADTFG LSQLHQLRGR
960 970 980 990 1000
VGRSRERGYA YFLYPPQVPL TETAYDRLAT IAQNNELGAG MAVALKDLEI
1010 1020 1030 1040 1050
RGAGNVLGIE QSGHVAGVGF DLYVRLVGEA LETYRDAYRA AADGQTVRTA
1060 1070 1080 1090 1100
EEPKDVRIDL PVDAHLPPDY IASDRLRLEG YRRLAAASSD REVAAVVDEL
1110 1120 1130 1140 1150
TDRYGALPEP ARRLAAVARL RLLCRGSGIT DVTAASAATV RLSPLTLPDS
1160 1170 1180 1190 1200
AQVRLKRMYP GAHYRATTAT VQVPIPRAGG LGAPRIRDVE LVQMVADLIT
1210 1220 1230
ALAGKPRQHI GITNPSPPGE DGRGRNTTIK ERQP
Length:1,234
Mass (Da):132,908
Last modified:April 16, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDBE48CE5ACF42B7D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP43770.1

Protein sequence database of the Protein Information Resource

More...
PIRi
G70622

NCBI Reference Sequences

More...
RefSeqi
NP_215536.1, NC_000962.3
WP_003405273.1, NZ_NVQJ01000018.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CCP43770; CCP43770; Rv1020

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
886077

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mtu:Rv1020
mtv:RVBD_1020

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP43770.1
PIRiG70622
RefSeqiNP_215536.1, NC_000962.3
WP_003405273.1, NZ_NVQJ01000018.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6ACAX-ray3.60A1-1234[»]
SMRiP9WMQ5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

IntActiP9WMQ5, 1 interactor
STRINGi83332.Rv1020

Proteomic databases

PaxDbiP9WMQ5
PRIDEiP9WMQ5

Genome annotation databases

EnsemblBacteriaiCCP43770; CCP43770; Rv1020
GeneIDi886077
KEGGimtu:Rv1020
mtv:RVBD_1020

Organism-specific databases

TubercuListiRv1020

Phylogenomic databases

eggNOGiENOG4108JA2 Bacteria
COG1197 LUCA
KOiK03723
OMAiKRGQPGD
PhylomeDBiP9WMQ5

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-5179-MONOMER

Family and domain databases

Gene3Di2.30.30.840, 1 hit
3.90.1150.50, 1 hit
HAMAPiMF_00969 TRCF, 1 hit
InterProiView protein in InterPro
IPR036101 CarD-like/TRCF_dom_sf
IPR003711 CarD-like/TRCF_domain
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR004576 Mfd
IPR027417 P-loop_NTPase
IPR037235 TRCF-like_C
IPR005118 TRCF_C
IPR041471 UvrB_inter
PfamiView protein in Pfam
PF02559 CarD_CdnL_TRCF, 1 hit
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
PF03461 TRCF, 1 hit
PF17757 UvrB_inter, 1 hit
SMARTiView protein in SMART
SM01058 CarD_TRCF, 1 hit
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00982 TRCF, 1 hit
SUPFAMiSSF141259 SSF141259, 1 hit
SSF143517 SSF143517, 1 hit
SSF52540 SSF52540, 4 hits
TIGRFAMsiTIGR00580 mfd, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMFD_MYCTU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P9WMQ5
Secondary accession number(s): L0T5H3, P64326, P96380
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: October 16, 2019
This is version 31 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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