UniProtKB - P9WME7 (Y1828_MYCTU)
Protein
Uncharacterized HTH-type transcriptional regulator Rv1828
Gene
Rv1828
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Transcriptional regulator that binds to its own promoter and thus may play a role in the regulation of the cotranscribed genes Rv1827 and Rv1828. Can also bind several promoter regions of genes that are essential, including ftsZ. Binds to the imperfect everted repeat sequence CTCAA through its winged-HTH motif.1 Publication
Miscellaneous
Was identified as a high-confidence drug target.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 14 – 38 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
GO - Biological processi
- regulation of transcription, DNA-templated Source: InterPro
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Uncharacterized HTH-type transcriptional regulator Rv1828Curated |
Gene namesi | Ordered Locus Names:Rv1828 ORF Names:MTCY1A11.15c |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv1828 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000098168 | 1 – 247 | Uncharacterized HTH-type transcriptional regulator Rv1828Add BLAST | 247 |
Proteomic databases
PaxDbi | P9WME7 |
Expressioni
Inductioni
Autoregulated.1 Publication
Interactioni
Subunit structurei
Homodimer.
1 PublicationProtein-protein interaction databases
STRINGi | 83332.Rv1828 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P9WME7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 85 | HTH merR-typePROSITE-ProRule annotationAdd BLAST | 75 |
Domaini
Contains an N-terminal DNA-binding domain, a linker region and a C-terminal effector binding domain. Dimerization is mediated via the C-terminal domain.1 Publication
Phylogenomic databases
eggNOGi | COG0789, Bacteria |
OMAi | NPQTRAH |
PhylomeDBi | P9WME7 |
Family and domain databases
InterProi | View protein in InterPro IPR009061, DNA-bd_dom_put_sf IPR000551, MerR-type_HTH_dom |
Pfami | View protein in Pfam PF00376, MerR, 1 hit |
SMARTi | View protein in SMART SM00422, HTH_MERR, 1 hit |
SUPFAMi | SSF46955, SSF46955, 1 hit |
PROSITEi | View protein in PROSITE PS50937, HTH_MERR_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WME7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSAPDSPALA GMSIGAVLDL LRPDFPDVTI SKIRFLEAEG LVTPRRASSG
60 70 80 90 100
YRRFTAYDCA RLRFILTAQR DHYLPLKVIR AQLDAQPDGE LPPFGSPYVL
110 120 130 140 150
PRLVPVAGDS AGGVGSDTAS VSLTGIRLSR EDLLERSEVA DELLTALLKA
160 170 180 190 200
GVITTGPGGF FDEHAVVILQ CARALAEYGV EPRHLRAFRS AADRQSDLIA
210 220 230 240
QIAGPLVKAG KAGARDRADD LAREVAALAI TLHTSLIKSA VRDVLHR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP44594.1 |
PIRi | E70721 |
RefSeqi | NP_216344.1, NC_000962.3 WP_003409239.1, NZ_NVQJ01000013.1 |
Genome annotation databases
EnsemblBacteriai | CCP44594; CCP44594; Rv1828 |
GeneIDi | 23492001 885336 |
KEGGi | mtu:Rv1828 mtv:RVBD_1828 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP44594.1 |
PIRi | E70721 |
RefSeqi | NP_216344.1, NC_000962.3 WP_003409239.1, NZ_NVQJ01000013.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5YDC | X-ray | 1.91 | A/B | 127-247 | [»] | |
5YDD | X-ray | 1.50 | A/B | 127-247 | [»] | |
SMRi | P9WME7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv1828 |
Proteomic databases
PaxDbi | P9WME7 |
Genome annotation databases
EnsemblBacteriai | CCP44594; CCP44594; Rv1828 |
GeneIDi | 23492001 885336 |
KEGGi | mtu:Rv1828 mtv:RVBD_1828 |
Organism-specific databases
TubercuListi | Rv1828 |
Phylogenomic databases
eggNOGi | COG0789, Bacteria |
OMAi | NPQTRAH |
PhylomeDBi | P9WME7 |
Family and domain databases
InterProi | View protein in InterPro IPR009061, DNA-bd_dom_put_sf IPR000551, MerR-type_HTH_dom |
Pfami | View protein in Pfam PF00376, MerR, 1 hit |
SMARTi | View protein in SMART SM00422, HTH_MERR, 1 hit |
SUPFAMi | SSF46955, SSF46955, 1 hit |
PROSITEi | View protein in PROSITE PS50937, HTH_MERR_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Y1828_MYCTU | |
Accessioni | P9WME7Primary (citable) accession number: P9WME7 Secondary accession number(s): L0TAQ6, P67669, Q50605 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | October 7, 2020 | |
This is version 33 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references