UniProtKB - P9WMB9 (KSTR2_MYCTU)
Protein
HTH-type transcriptional repressor KstR2
Gene
kstR2
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Controls the expression of a small regulon that may play a role in the utilization of cholesterol.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 32 – 51 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 20 |
GO - Molecular functioni
- DNA binding Source: UniProtKB
- DNA-binding transcription factor activity Source: GO_Central
- transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription, DNA-templated Source: UniProtKB
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: HTH-type transcriptional repressor KstR2 |
Gene namesi | Name:kstR2 Ordered Locus Names:Rv3557c |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv3557c |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000405031 | 1 – 200 | HTH-type transcriptional repressor KstR2Add BLAST | 200 |
Proteomic databases
PaxDbi | P9WMB9 |
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
STRINGi | 83332.Rv3557c |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P9WMB9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 69 | HTH tetR-typePROSITE-ProRule annotationAdd BLAST | 61 |
Phylogenomic databases
eggNOGi | COG1309, Bacteria |
OMAi | ARQYLSM |
PhylomeDBi | P9WMB9 |
Family and domain databases
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR001647, HTH_TetR IPR041490, KstR2_TetR_C IPR036271, Tet_transcr_reg_TetR-rel_C_sf |
Pfami | View protein in Pfam PF17932, TetR_C_24, 1 hit PF00440, TetR_N, 1 hit |
PRINTSi | PR00455, HTHTETR |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF48498, SSF48498, 1 hit |
PROSITEi | View protein in PROSITE PS50977, HTH_TETR_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WMB9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDRVAGQVNS RRGELLELAA AMFAERGLRA TTVRDIADGA GILSGSLYHH
60 70 80 90 100
FASKEEMVDE LLRGFLDWLF ARYRDIVDST ANPLERLQGL FMASFEAIEH
110 120 130 140 150
HHAQVVIYQD EAQRLASQPR FSYIEDRNKQ QRKMWVDVLN QGIEEGYFRP
160 170 180 190 200
DLDVDLVYRF IRDTTWVSVR WYRPGGPLTA QQVGQQYLAI VLGGITKEGV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP46379.1 |
PIRi | C70604 |
RefSeqi | NP_218074.1, NC_000962.3 WP_003419329.1, NZ_NVQJ01000014.1 |
Genome annotation databases
EnsemblBacteriai | CCP46379; CCP46379; Rv3557c |
GeneIDi | 23490169 887467 |
KEGGi | mtu:Rv3557c mtv:RVBD_3557c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP46379.1 |
PIRi | C70604 |
RefSeqi | NP_218074.1, NC_000962.3 WP_003419329.1, NZ_NVQJ01000014.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4W1U | X-ray | 1.88 | A | 1-200 | [»] | |
4W97 | X-ray | 1.60 | A | 2-200 | [»] | |
SMRi | P9WMB9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv3557c |
Proteomic databases
PaxDbi | P9WMB9 |
Genome annotation databases
EnsemblBacteriai | CCP46379; CCP46379; Rv3557c |
GeneIDi | 23490169 887467 |
KEGGi | mtu:Rv3557c mtv:RVBD_3557c |
Organism-specific databases
TubercuListi | Rv3557c |
Phylogenomic databases
eggNOGi | COG1309, Bacteria |
OMAi | ARQYLSM |
PhylomeDBi | P9WMB9 |
Family and domain databases
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR001647, HTH_TetR IPR041490, KstR2_TetR_C IPR036271, Tet_transcr_reg_TetR-rel_C_sf |
Pfami | View protein in Pfam PF17932, TetR_C_24, 1 hit PF00440, TetR_N, 1 hit |
PRINTSi | PR00455, HTHTETR |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF48498, SSF48498, 1 hit |
PROSITEi | View protein in PROSITE PS50977, HTH_TETR_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KSTR2_MYCTU | |
Accessioni | P9WMB9Primary (citable) accession number: P9WMB9 Secondary accession number(s): L0TD56, P96839, Q7D5A5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | December 2, 2020 | |
This is version 38 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references