UniProtKB - P9WK15 (MBTK_MYCTU)
Protein
Lysine N-acyltransferase MbtK
Gene
mbtK
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Acyltransferase required for the direct transfer of medium- to long-chain fatty acyl moieties from a carrier protein (MbtL) on to the epsilon-amino group of lysine residue in the mycobactin core.1 Publication
Kineticsi
- KM=0.72 µM for lauroyl-ACP1 Publication
- KM=19.50 µM for palmitoyl-CoA1 Publication
- KM=33.93 µM for lauroyl-CoA1 Publication
- KM=86.12 µM for decanoyl-CoA1 Publication
- KM=166.20 µM for hexanoyl-CoA1 Publication
: mycobactin biosynthesis Pathwayi
This protein is involved in the pathway mycobactin biosynthesis, which is part of Siderophore biosynthesis.View all proteins of this organism that are known to be involved in the pathway mycobactin biosynthesis and in Siderophore biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 130 | SubstrateSequence analysis | 1 | |
Active sitei | 168 | Proton acceptorSequence analysis | 1 |
GO - Molecular functioni
- acyl-CoA hydrolase activity Source: MTBBASE
- N-acyltransferase activity Source: MTBBASE
- transferase activity, transferring acyl groups other than amino-acyl groups Source: MTBBASE
GO - Biological processi
- siderophore biosynthetic process from catechol Source: MTBBASE
Keywordsi
Molecular function | Acyltransferase, Transferase |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-5526-MONOMER |
UniPathwayi | UPA00011 |
Names & Taxonomyi
Protein namesi | Recommended name: Lysine N-acyltransferase MbtK (EC:2.3.1.-)Short name: N-acyltransferase MbtK Alternative name(s): Mycobactin synthase protein K |
Gene namesi | Name:mbtK Ordered Locus Names:Rv1347c ORF Names:MTCY02B10.11c |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv1347c |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000103819 | 1 – 210 | Lysine N-acyltransferase MbtKAdd BLAST | 210 |
Proteomic databases
PaxDbi | P9WK15 |
Expressioni
Inductioni
Induced by iron starvation conditions. Transcriptionally repressed by IdeR and iron.1 Publication
Interactioni
Subunit structurei
Monomer.
1 PublicationProtein-protein interaction databases
STRINGi | 83332.Rv1347c |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P9WK15 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the lysine N-acyltransferase MbtK family.Curated
Phylogenomic databases
eggNOGi | ENOG4105NP3 Bacteria COG1670 LUCA |
KOi | K21992 |
OMAi | MALYALH |
PhylomeDBi | P9WK15 |
Family and domain databases
InterProi | View protein in InterPro IPR016181 Acyl_CoA_acyltransferase IPR019432 Siderophore_biosyn_cons_dom |
SMARTi | View protein in SMART SM01006 AlcB, 1 hit |
SUPFAMi | SSF55729 SSF55729, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WK15-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTKPTSAGQA DDALVRLARE RFDLPDQVRR LARPPVPSLE PPYGLRVAQL
60 70 80 90 100
TDAEMLAEWM NRPHLAAAWE YDWPASRWRQ HLNAQLEGTY SLPLIGSWHG
110 120 130 140 150
TDGGYLELYW AAKDLISHYY DADPYDLGLH AAIADLSKVN RGFGPLLLPR
160 170 180 190 200
IVASVFANEP RCRRIMFDPD HRNTATRRLC EWAGCKFLGE HDTTNRRMAL
210
YALEAPTTAA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP44105.1 |
PIRi | B70740 |
RefSeqi | NP_215863.1, NC_000962.3 WP_003406956.1, NZ_NVQJ01000031.1 |
Genome annotation databases
EnsemblBacteriai | CCP44105; CCP44105; Rv1347c |
GeneIDi | 886846 |
KEGGi | mtu:Rv1347c mtv:RVBD_1347c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP44105.1 |
PIRi | B70740 |
RefSeqi | NP_215863.1, NC_000962.3 WP_003406956.1, NZ_NVQJ01000031.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1YK3 | X-ray | 2.20 | A/B/C/D/E/F/G/H | 1-210 | [»] | |
SMRi | P9WK15 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv1347c |
Proteomic databases
PaxDbi | P9WK15 |
Genome annotation databases
EnsemblBacteriai | CCP44105; CCP44105; Rv1347c |
GeneIDi | 886846 |
KEGGi | mtu:Rv1347c mtv:RVBD_1347c |
Organism-specific databases
TubercuListi | Rv1347c |
Phylogenomic databases
eggNOGi | ENOG4105NP3 Bacteria COG1670 LUCA |
KOi | K21992 |
OMAi | MALYALH |
PhylomeDBi | P9WK15 |
Enzyme and pathway databases
UniPathwayi | UPA00011 |
BioCyci | MTBH37RV:G185E-5526-MONOMER |
Family and domain databases
InterProi | View protein in InterPro IPR016181 Acyl_CoA_acyltransferase IPR019432 Siderophore_biosyn_cons_dom |
SMARTi | View protein in SMART SM01006 AlcB, 1 hit |
SUPFAMi | SSF55729 SSF55729, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MBTK_MYCTU | |
Accessioni | P9WK15Primary (citable) accession number: P9WK15 Secondary accession number(s): L0T804, P64819, Q11017 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | October 16, 2019 | |
This is version 28 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references