Phthiocerol dimycocerosate exporter MmpL7

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• cell wall organization Source: UniProtKB-KW
• drug transmembrane transport Source: MTBBASE <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.5

    "mmpL7 gene of Mycobacterium tuberculosis is responsible for isoniazid efflux in Mycobacterium smegmatis."
    Pasca M.R., Guglierame P., De Rossi E., Zara F., Riccardi G.
    Antimicrob. Agents Chemother. 49:4775-4777(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN M.SMEGMATIS.
• growth of symbiont in host cell Source: MTBBASEInferred from mutant phenotypeⁱ
  • "Identification of a virulence gene cluster of Mycobacterium tuberculosis by signature-tagged transposon mutagenesis."
    Camacho L.R., Ensergueix D., Perez E., Gicquel B., Guilhot C.
    Mol. Microbiol. 34:257-267(1999) [PubMed] [Europe PMC] [Abstract]
• lipid transport Source: MTBBASEInferred from mutant phenotypeⁱ
  • Ref.2

    "Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice."
    Cox J.S., Chen B., McNeil M., Jacobs W.R. Jr.
    Nature 402:79-83(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  • Ref.3

    "Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier."
    Camacho L.R., Constant P., Raynaud C., Laneelle M.A., Triccas J.A., Gicquel B., Daffe M., Guilhot C.
    J. Biol. Chem. 276:19845-19854(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
• pathogenesis Source: UniProtKB-KW
• response to host immune response Source: MTBBASEInferred from mutant phenotypeⁱ
  • "Identification of a virulence gene cluster of Mycobacterium tuberculosis by signature-tagged transposon mutagenesis."
    Camacho L.R., Ensergueix D., Perez E., Gicquel B., Guilhot C.
    Mol. Microbiol. 34:257-267(1999) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

GO - Cellular componentⁱ

• integral component of plasma membrane Source: MTBBASEInferred from high throughput direct assayⁱ
  • "Identification of Mycobacterium tuberculosis H37Rv integral membrane proteins by one-dimensional gel electrophoresis and liquid chromatography electrospray ionization tandem mass spectrometry."
    Xiong Y., Chalmers M.J., Gao F.P., Cross T.A., Marshall A.G.
    J. Proteome Res. 4:855-861(2005) [PubMed] [Europe PMC] [Abstract]

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MPSPAGRLHR IRYIRLKKSS PDCRATITSG SADGQRRSPR LTNLLVVAAW 
        60         70         80         90        100
VAAAVIANLL LTFTQAEPHD TSPALLPQDA KTAAATSRIA QAFPGTGSNA 
       110        120        130        140        150
IAYLVVEGGS TLEPQDQPYY DAAVGALRAD TRHVGSVLDW WSDPVTAPLG 
       160        170        180        190        200
TSPDGRSATA MVWLRGEAGT TQAAESLDAV RSVLRQLPPS EGLRASIVVP 
       210        220        230        240        250
AITNDMPMQI TAWQSATIVT VAAVIAVLLL LRARLSVRAA AIVLLTADLS 
       260        270        280        290        300
LAVAWPLAAV VRGHDWGTDS VFSWTLAAVL TIGTITAATM LAARLGSDAG 
       310        320        330        340        350
HSAAPTYRDS LPAFALPGAC VAIFTGPLLL ARTPALHGVG TAGLGVFVAL 
       360        370        380        390        400
AASLTVLPAL IALAGASRQL PAPTTGAGWT GRLSLPVSSA SALGTAAVLA 
       410        420        430        440        450
ICMLPIIGMR WGVAENPTRQ GGAQVLPGNA LPDVVVIKSA RDLRDPAALI 
       460        470        480        490        500
AINQVSHRLV EVPGVRKVES AAWPAGVPWT DASLSSAAGR LADQLGQQAG 
       510        520        530        540        550
SFVPAVTAIK SMKSIIEQMS GAVDQLDSTV NVTLAGARQA QQYLDPMLAA 
       560        570        580        590        600
ARNLKNKTTE LSEYLETIHT WIVGFTNCPD DVLCTAMRKV IEPYDIVVTG 
       610        620        630        640        650
MNELSTGADR ISAISTQTMS ALSSAPRMVA QMRSALAQVR SFVPKLETTI 
       660        670        680        690        700
QDAMPQIAQA SAMLKNLSAD FADTGEGGFH LSRKDLADPS YRHVRESMFS 
       710        720        730        740        750
SDGTATRLFL YSDGQLDLAA AARAQQLEIA AGKAMKYGSL VDSQVTVGGA 
       760        770        780        790        800
AQIAAAVRDA LIHDAVLLAV ILLTVVALAS MWRGAVHGAA VGVGVLASYL 
       810        820        830        840        850
AALGVSIALW QHLLDRELNA LVPLVSFAVL ASCGVPYLVA GIKAGRIADE 
       860        870        880        890        900
ATGARSKGAV SGRGAVAPLA ALGGVFGAGL VLVSGGSFSV LSQIGTVVVL 
       910        920
GLGVLITVQR AWLPTTPGRR                                  

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families