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Entry version 25 (16 Oct 2019)
Sequence version 1 (16 Apr 2014)
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Protein

Probable transport protein MmpL12

Gene

mmpL12

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MTBH37RV:G185E-5710-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable transport protein MmpL12Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mmpL12
Ordered Locus Names:Rv1522c
ORF Names:MTCY19G5.06
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83332 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001584 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

Organism-specific databases

Mycobacterium tuberculosis strain H37Rv genome database

More...
TubercuListi
Rv1522c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Transmembranei254 – 274HelicalSequence analysisAdd BLAST21
Transmembranei298 – 318HelicalSequence analysisAdd BLAST21
Transmembranei330 – 350HelicalSequence analysisAdd BLAST21
Transmembranei382 – 402HelicalSequence analysisAdd BLAST21
Transmembranei826 – 846HelicalSequence analysisAdd BLAST21
Transmembranei850 – 870HelicalSequence analysisAdd BLAST21
Transmembranei883 – 903HelicalSequence analysisAdd BLAST21
Transmembranei928 – 948HelicalSequence analysisAdd BLAST21
Transmembranei949 – 969HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001035801 – 1146Probable transport protein MmpL12Add BLAST1146

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P9WJT7

PRoteomics IDEntifications database

More...
PRIDEi
P9WJT7

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
83332.Rv1522c

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105EYF Bacteria
COG2409 LUCA

KEGG Orthology (KO)

More...
KOi
K06994

Identification of Orthologs from Complete Genome Data

More...
OMAi
MHLIEIA

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P9WJT7

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004869 MMPL_dom
IPR004707 MmpL_fam
IPR000731 SSD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03176 MMPL, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00833 actII, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50156 SSD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P9WJT7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARHDEAKAG GLFDRIGNFV VRWPLIVIGC WIAVAAALTL LLPTLQAQAA
60 70 80 90 100
KREQAPLPPG APSMVLQKEM SAAFQEKIET SALLLVLLTN ENGLGPADEA
110 120 130 140 150
VYRKLIENLR ADTQDKISVQ DFLAVPEMKE LLASKDNKAW NLPITFAGDA
160 170 180 190 200
ASPETQAAFK RVAAIVKQTV AGTSLTVHLS GPIATVADLT ELGEKDVRII
210 220 230 240 250
EIGTAVSVLI ILILVYRNLV TMLVPLATIG ASVVTAQGTL SGLAEFGLAV
260 270 280 290 300
NMQAIVFMSA VMIGAGTDYA VFLISRYHDY VRHGEKSDMA VKKALMSIGK
310 320 330 340 350
VITASAATVA VTFLAMVFTK LEVFSAVGPA IAVAITVSLL GAVTLLPAIL
360 370 380 390 400
TLTGRRGWIK PRRDLTSRMW RRSGVRIVRR STIHLVGSLI VLVALAGCTL
410 420 430 440 450
LIRFNYDDLK TVPQHVESVK GYEAMNRHFP MNAMTPMVLF IKSPRDLRTP
460 470 480 490 500
GALADIEMMS REIAELPNIV MVRGLTRPNG EPLKETKVSF QAGEVGGKLD
510 520 530 540 550
EATTLLEEHG GELDQLTGGA HQLADALAQI RNEINGAVAS SSGIVNTLQA
560 570 580 590 600
MMDLMGGDKT IRQLENASQY VGRMRALGDN LSGTVTDAEQ IATWASPMVN
610 620 630 640 650
ALNSSPVCNS DPACRTSRAQ LAAIVQAQDD GLLRSIRALA VTLQQTQEYQ
660 670 680 690 700
TLARTVSTLD GQLKQVVSTL KAVDGLPTKL AQMQQGANAL ADGSAALAAG
710 720 730 740 750
VQELVDQVKK MGSGLNEAAD FLLGIKRDAD KPSMAGFNIP PQIFSRDEFK
760 770 780 790 800
KGAQIFLSAD GHAARYFVQS ALNPATTEAM DQVNDILRVA DSARPNTELE
810 820 830 840 850
DATIGLAGVP TALRDIRDYY NSDMKFIVIA TIVIVFLILV ILLRALVAPI
860 870 880 890 900
YLIGSVLISY LSALGIGTLV FQLILGQEMH WSLPGLSFIL LVAIGADYNM
910 920 930 940 950
LLISRIRDES PHGIRIGVIR TVGSTGGVIT SAGLIFAASM FGLVGASINT
960 970 980 990 1000
MAQAGFTIGI GIVLDTFLVR TVTVPALTTM IGRANWWPSE LGRDPSTPPT
1010 1020 1030 1040 1050
KADRWLRRVK GHRRKAPIPA PKPPHTKVVR NTNGHASKAA TKSVPNGKPA
1060 1070 1080 1090 1100
DLAEGNGEYL IDHLRRHSLP LFGYAAMPAY DVVDGVSKPN GDGAHIGKEP
1110 1120 1130 1140
VDHLLGHSLP LFGLAGLPSY DRWDDTSIGE PAVGHAGSKP DAKLST
Length:1,146
Mass (Da):122,430
Last modified:April 16, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAC03075641C5CB09
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP44286.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B70723

NCBI Reference Sequences

More...
RefSeqi
NP_216038.1, NC_000962.3
WP_003898915.1, NZ_NVQJ01000004.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CCP44286; CCP44286; Rv1522c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
886445

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mtu:Rv1522c
mtv:RVBD_1522c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP44286.1
PIRiB70723
RefSeqiNP_216038.1, NC_000962.3
WP_003898915.1, NZ_NVQJ01000004.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi83332.Rv1522c

Proteomic databases

PaxDbiP9WJT7
PRIDEiP9WJT7

Genome annotation databases

EnsemblBacteriaiCCP44286; CCP44286; Rv1522c
GeneIDi886445
KEGGimtu:Rv1522c
mtv:RVBD_1522c

Organism-specific databases

TubercuListiRv1522c

Phylogenomic databases

eggNOGiENOG4105EYF Bacteria
COG2409 LUCA
KOiK06994
OMAiMHLIEIA
PhylomeDBiP9WJT7

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-5710-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR004869 MMPL_dom
IPR004707 MmpL_fam
IPR000731 SSD
PfamiView protein in Pfam
PF03176 MMPL, 2 hits
TIGRFAMsiTIGR00833 actII, 1 hit
PROSITEiView protein in PROSITE
PS50156 SSD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMMPLC_MYCTU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P9WJT7
Secondary accession number(s): L0T6X0, Q50585
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: October 16, 2019
This is version 25 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
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