UniProtKB - P9WIX3 (NUOK_MYCTU)
Protein
NADH-quinone oxidoreductase subunit K
Gene
nuoK
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation
Catalytic activityi
GO - Molecular functioni
- NADH dehydrogenase (ubiquinone) activity Source: GO_Central
- quinone binding Source: UniProtKB-KW
GO - Biological processi
- ATP synthesis coupled electron transport Source: InterPro
Keywordsi
Molecular function | Translocase |
Biological process | Transport |
Ligand | NAD |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-7420-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: NADH-quinone oxidoreductase subunit KUniRule annotation (EC:7.1.1.-UniRule annotation)Alternative name(s): NADH dehydrogenase I subunit KUniRule annotation NDH-1 subunit KUniRule annotation |
Gene namesi | Name:nuoKUniRule annotation Ordered Locus Names:Rv3155 ORF Names:MTCY03A2.03c |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv3155 |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 3 – 23 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 28 – 48 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 59 – 79 | HelicalUniRule annotationAdd BLAST | 21 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- NADH dehydrogenase complex Source: GO_Central
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000118532 | 1 – 99 | NADH-quinone oxidoreductase subunit KAdd BLAST | 99 |
Keywords - PTMi
QuinoneProteomic databases
PaxDbi | P9WIX3 |
Interactioni
Subunit structurei
NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
UniRule annotationProtein-protein interaction databases
STRINGi | 83332.Rv3155 |
Family & Domainsi
Sequence similaritiesi
Belongs to the complex I subunit 4L family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG4105M5H Bacteria COG0713 LUCA |
KOi | K00340 |
OMAi | MNPVNYL |
PhylomeDBi | P9WIX3 |
Family and domain databases
HAMAPi | MF_01456 NDH1_NuoK, 1 hit |
InterProi | View protein in InterPro IPR001133 NADH_UbQ_OxRdtase_chain4L/K IPR039428 NUOK/Mnh_C1-like |
PANTHERi | PTHR11434 PTHR11434, 1 hit |
Pfami | View protein in Pfam PF00420 Oxidored_q2, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WIX3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNPANYLYLS VLLFTIGASG VLLRRNAIVM FMCVELMLNA VNLAFVTFAR
60 70 80 90
MHGHLDAQMI AFFTMVVAAC EVVVGLAIIM TIFRTRKSAS VDDANLLKG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP45966.1 |
PIRi | D70648 |
RefSeqi | NP_217671.1, NC_000962.3 WP_003416452.1, NZ_NVQJ01000019.1 |
Genome annotation databases
EnsemblBacteriai | CCP45966; CCP45966; Rv3155 |
GeneIDi | 888764 |
KEGGi | mtu:Rv3155 mtv:RVBD_3155 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP45966.1 |
PIRi | D70648 |
RefSeqi | NP_217671.1, NC_000962.3 WP_003416452.1, NZ_NVQJ01000019.1 |
3D structure databases
SMRi | P9WIX3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv3155 |
Proteomic databases
PaxDbi | P9WIX3 |
Genome annotation databases
EnsemblBacteriai | CCP45966; CCP45966; Rv3155 |
GeneIDi | 888764 |
KEGGi | mtu:Rv3155 mtv:RVBD_3155 |
Organism-specific databases
TubercuListi | Rv3155 |
Phylogenomic databases
eggNOGi | ENOG4105M5H Bacteria COG0713 LUCA |
KOi | K00340 |
OMAi | MNPVNYL |
PhylomeDBi | P9WIX3 |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-7420-MONOMER |
Family and domain databases
HAMAPi | MF_01456 NDH1_NuoK, 1 hit |
InterProi | View protein in InterPro IPR001133 NADH_UbQ_OxRdtase_chain4L/K IPR039428 NUOK/Mnh_C1-like |
PANTHERi | PTHR11434 PTHR11434, 1 hit |
Pfami | View protein in Pfam PF00420 Oxidored_q2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NUOK_MYCTU | |
Accessioni | P9WIX3Primary (citable) accession number: P9WIX3 Secondary accession number(s): L0TDB2, P65565, P95171 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | October 16, 2019 | |
This is version 26 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names