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Entry version 34 (16 Oct 2019)
Sequence version 1 (16 Apr 2014)
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Protein

RecBCD enzyme subunit RecC

Gene

recC

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides.UniRule annotation EC:3.1.11.5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Exonuclease, Helicase, Hydrolase, Nuclease
Biological processDNA damage, DNA repair
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MTBH37RV:G185E-4769-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RecBCD enzyme subunit RecCUniRule annotation (EC:3.1.11.5UniRule annotation)
Alternative name(s):
Exonuclease V subunit RecCUniRule annotation
Short name:
ExoV subunit RecCUniRule annotation
Helicase/nuclease RecBCD subunit RecCUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:recCUniRule annotation
Ordered Locus Names:Rv0631c
ORF Names:MTCY20H10.12c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83332 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001584 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

Organism-specific databases

Mycobacterium tuberculosis strain H37Rv genome database

More...
TubercuListi
Rv0631c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000871221 – 1097RecBCD enzyme subunit RecCAdd BLAST1097

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P9WIQ5

PRoteomics IDEntifications database

More...
PRIDEi
P9WIQ5

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

UniRule annotation

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
83332.Rv0631c

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P9WIQ5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RecC family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105DSY Bacteria
COG1330 LUCA

KEGG Orthology (KO)

More...
KOi
K03583

Identification of Orthologs from Complete Genome Data

More...
OMAi
MCPDIET

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P9WIQ5

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.160, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01486 RecC, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013986 DExx_box_DNA_helicase_dom_sf
IPR027417 P-loop_NTPase
IPR006697 RecC
IPR041500 RecC_C
IPR011335 Restrct_endonuc-II-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17946 RecC_C, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000980 RecC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF52980 SSF52980, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01450 recC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P9WIQ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALHLHRAER TDLLADGLGA LLADPQPDPF AQELVLVAAR GVERWLSQRL
60 70 80 90 100
SLVLGCGPGR ADGVCAGIAF RNPQSLIAEI TGTLDDDPWS PEALAWPLLA
110 120 130 140 150
VIDASLDEPW CRTLASHLGH FATTDAEAEL RRGRRYSVAR RLAGLFASYA
160 170 180 190 200
RQRPGLLAAW LDGDLGELPG DLAWQPPLWR ALVTTVGADP PHVRHDKTIA
210 220 230 240 250
RLRDGPADLP ARLSLFGHTR LACTDVQLLD ALAVHHDLHL WLPHPSDELW
260 270 280 290 300
RALAGFQGAD GLLPRRQDTS RRAAQHPLLE TLGRDVRELQ RALPAARATD
310 320 330 340 350
EFLGATTKPD TLLGWLQADI AGNAPRPAGR SLSDADRSVQ VHACHGPARQ
360 370 380 390 400
IDVLREVLLG LLEDDPTLQP RDIVVMCPDI DTYAPLIVAG FGLGEVAGDC
410 420 430 440 450
HPAHRLRVRL ADRALTQTNP LLSVAAELLT IAETRATASQ LLNLAQAAPV
460 470 480 490 500
RAKFGFADDD LDTITTWVRE SNIRWGFDPT HRRRYGLDTV VHNTWRFGLD
510 520 530 540 550
RILTGVAMSE DSQAWLDTAL PLDDVGSNRV ELAGRLAEFV ERLHHVVGGL
560 570 580 590 600
SGARPLVAWL DALATGIDLL TACNDGWQRA QVQREFADVL ARAGSRAAPL
610 620 630 640 650
LRLPDVRALL DAQLAGRPTR ANFRTGTLTV CTMVPMRSVP HRVVCLVGLD
660 670 680 690 700
DGVFPRLSHP DGDDVLAREP MTGERDIRSE DRQLLLDAIG AATQTLVITY
710 720 730 740 750
TGADERTGQP RPPAVPLAEL LDALDQTTSA PVRERILVTH PLQPFDRKNV
760 770 780 790 800
TPGALLGAKP FTFDPAALAA AQAAAGKRCP PTAFISGRLP APPAADVTLA
810 820 830 840 850
DLLDFFKDPV KGFFRALDYT LPWDVDTVED SIPVQVDALA EWTVGERMLR
860 870 880 890 900
DMLRGLHPDD AAHSEWRRGT LPPGRLGVRR AKEIRNRARD LAAAALAHRD
910 920 930 940 950
GHGQAHDVDV DLGDGRRLSG TVTPVFGGRT VSVTYSKLAP KHVLPAWIGL
960 970 980 990 1000
VTLAAQEPGR EWSALCIGRS KTRNHIARRL FVPPPDPVAV LRELVLLYDA
1010 1020 1030 1040 1050
GRREPLPLPL KTSCAWAQAR RDGQDPYPPA RECWQTNRFR PGDDDAPAHV
1060 1070 1080 1090
RAWGPRAPFE VLLGKPRAGE EVAGEETRLG ALAARLWLPL LAAEGSV
Length:1,097
Mass (Da):119,501
Last modified:April 16, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD23908283F18D580
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP43372.1

Protein sequence database of the Protein Information Resource

More...
PIRi
D70612

NCBI Reference Sequences

More...
RefSeqi
NP_215145.1, NC_000962.3
WP_003900193.1, NZ_KK339370.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CCP43372; CCP43372; Rv0631c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
888008

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mtu:Rv0631c
mtv:RVBD_0631c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP43372.1
PIRiD70612
RefSeqiNP_215145.1, NC_000962.3
WP_003900193.1, NZ_KK339370.1

3D structure databases

SMRiP9WIQ5
ModBaseiSearch...

Protein-protein interaction databases

STRINGi83332.Rv0631c

Proteomic databases

PaxDbiP9WIQ5
PRIDEiP9WIQ5

Genome annotation databases

EnsemblBacteriaiCCP43372; CCP43372; Rv0631c
GeneIDi888008
KEGGimtu:Rv0631c
mtv:RVBD_0631c

Organism-specific databases

TubercuListiRv0631c

Phylogenomic databases

eggNOGiENOG4105DSY Bacteria
COG1330 LUCA
KOiK03583
OMAiMCPDIET
PhylomeDBiP9WIQ5

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-4769-MONOMER

Family and domain databases

Gene3Di1.10.10.160, 1 hit
HAMAPiMF_01486 RecC, 1 hit
InterProiView protein in InterPro
IPR013986 DExx_box_DNA_helicase_dom_sf
IPR027417 P-loop_NTPase
IPR006697 RecC
IPR041500 RecC_C
IPR011335 Restrct_endonuc-II-like
PfamiView protein in Pfam
PF17946 RecC_C, 1 hit
PIRSFiPIRSF000980 RecC, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
SSF52980 SSF52980, 1 hit
TIGRFAMsiTIGR01450 recC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRECC_MYCTU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P9WIQ5
Secondary accession number(s): L0T7A5, P96921
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: October 16, 2019
This is version 34 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
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