UniProtKB - P9WHY9 (PPE46_MYCTU)
Protein
Uncharacterized PPE family protein PPE46
Gene
PPE46
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Miscellaneous
Was identified as a high-confidence drug target.
Caution
Was originally (Ref. 2) thought to be a dihydrofolate reductase.Curated
GO - Biological processi
- growth of symbiont in host cell Source: MTBBASE
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-7276-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Uncharacterized PPE family protein PPE46 |
Gene namesi | Name:PPE46 Ordered Locus Names:Rv3018c ORF Names:MTV012.32c |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv3018c |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000217851 | 1 – 434 | Uncharacterized PPE family protein PPE46Add BLAST | 434 |
Proteomic databases
PaxDbi | P9WHY9 |
Family & Domainsi
Sequence similaritiesi
Belongs to the mycobacterial PPE family.Curated
Phylogenomic databases
OMAi | HWAGESL |
PhylomeDBi | P9WHY9 |
Family and domain databases
Gene3Di | 1.20.1260.20, 1 hit |
InterProi | View protein in InterPro IPR000030 PPE_family IPR038332 PPE_sf |
Pfami | View protein in Pfam PF00823 PPE, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WHY9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTAPVWLASP PEVHSALLSA GPGPGSLQAA AAGWSALSAE YAAVAQELSV
60 70 80 90 100
VVAAVGAGVW QGPSAELFVA AYVPYVAWLV QASADSAAAA GEHEAAAAGY
110 120 130 140 150
VCALAEMPTL PELAANHLTH AVLVATNFFG INTIPIALNE ADYVRMWVQA
160 170 180 190 200
ATVMSAYEAV VGAALVATPH TGPAPVIVKP GANEASNAVA AATITPFPWH
210 220 230 240 250
EIVQFLEETF AAYDQYLSAL LSELPAVAWV WFQLFVDILG FNIIGFIITL
260 270 280 290 300
ASNAQLLTEF AINASYVAVG LLYAIAGVID IVVEWVIGNL FGVVPLLGGP
310 320 330 340 350
LLGALAAAVV PGVAGLAGVA GLAALPAVGA AAGAPAALVG SVAPVSGGVV
360 370 380 390 400
SPQARLVSAV EPAPASTSVS VLASDRGAGA LGFVGTAGKE SVGQPAGLTV
410 420 430
LADEFGDGAP VPMLPGSWGP DLVGVAGDGG LVSV
Sequence cautioni
The sequence CAA41961 differs from that shown. Reason: Frameshift.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59271 Genomic DNA Translation: CAA41961.1 Frameshift. AL123456 Genomic DNA Translation: CCP45824.1 |
PIRi | E70857 |
RefSeqi | WP_003910691.1, NC_018143.2 YP_177918.1, NC_000962.3 |
Genome annotation databases
EnsemblBacteriai | CCP45824; CCP45824; Rv3018c |
GeneIDi | 888940 |
KEGGi | mtu:Rv3018c mtv:RVBD_3018c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59271 Genomic DNA Translation: CAA41961.1 Frameshift. AL123456 Genomic DNA Translation: CCP45824.1 |
PIRi | E70857 |
RefSeqi | WP_003910691.1, NC_018143.2 YP_177918.1, NC_000962.3 |
3D structure databases
SMRi | P9WHY9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv3018c |
Proteomic databases
PaxDbi | P9WHY9 |
Genome annotation databases
EnsemblBacteriai | CCP45824; CCP45824; Rv3018c |
GeneIDi | 888940 |
KEGGi | mtu:Rv3018c mtv:RVBD_3018c |
Organism-specific databases
TubercuListi | Rv3018c |
Phylogenomic databases
OMAi | HWAGESL |
PhylomeDBi | P9WHY9 |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-7276-MONOMER |
Family and domain databases
Gene3Di | 1.20.1260.20, 1 hit |
InterProi | View protein in InterPro IPR000030 PPE_family IPR038332 PPE_sf |
Pfami | View protein in Pfam PF00823 PPE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PPE46_MYCTU | |
Accessioni | P9WHY9Primary (citable) accession number: P9WHY9 Secondary accession number(s): L0TCW9, O53265, P31500 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | October 16, 2019 | |
This is version 24 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names