UniProtKB - P9WHH5 (STHA_MYCTU)
Protein
Probable soluble pyridine nucleotide transhydrogenase
Gene
sthA
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.By similarity
Catalytic activityi
- EC:1.6.1.1
Cofactori
FADBy similarityNote: Binds 1 FAD per subunit.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 33 – 42 | FADBy similarity | 10 |
GO - Molecular functioni
- electron transfer activity Source: InterPro
- flavin adenine dinucleotide binding Source: InterPro
- NAD(P)+ transhydrogenase (B-specific) activity Source: UniProtKB-UniRule
GO - Biological processi
- cell redox homeostasis Source: InterPro
- NADP metabolic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Oxidoreductase |
Ligand | FAD, Flavoprotein, NAD, NADP |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-6961-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Probable soluble pyridine nucleotide transhydrogenase (EC:1.6.1.1)Short name: STH Alternative name(s): NAD(P)(+) transhydrogenase [B-specific] |
Gene namesi | Name:sthA Ordered Locus Names:Rv2713 ORF Names:MTCY05A6.34 |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv2713 |
Subcellular locationi
- Cytoplasm By similarity
GO - Cellular componenti
- cell Source: GOC
- cell wall Source: MTBBASE
- cytosol Source: MTBBASE
- plasma membrane Source: MTBBASE
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000068065 | 1 – 468 | Probable soluble pyridine nucleotide transhydrogenaseAdd BLAST | 468 |
Proteomic databases
PaxDbi | P9WHH5 |
PRIDEi | P9WHH5 |
Family & Domainsi
Sequence similaritiesi
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.Curated
Phylogenomic databases
eggNOGi | ENOG4105DX1 Bacteria COG1249 LUCA |
KOi | K00322 |
OMAi | SGHAAWH |
PhylomeDBi | P9WHH5 |
Family and domain databases
Gene3Di | 3.30.390.30, 1 hit 3.50.50.60, 2 hits |
HAMAPi | MF_00247 SthA, 1 hit |
InterProi | View protein in InterPro IPR036188 FAD/NAD-bd_sf IPR023753 FAD/NAD-binding_dom IPR016156 FAD/NAD-linked_Rdtase_dimer_sf IPR001100 Pyr_nuc-diS_OxRdtase IPR004099 Pyr_nucl-diS_OxRdtase_dimer IPR022962 STH |
Pfami | View protein in Pfam PF07992 Pyr_redox_2, 1 hit PF02852 Pyr_redox_dim, 1 hit |
PIRSFi | PIRSF000350 Mercury_reductase_MerA, 1 hit |
SUPFAMi | SSF51905 SSF51905, 1 hit SSF55424 SSF55424, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WHH5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MREYDIVVIG SGPGGQKAAI ASAKLGKSVA IVERGRMLGG VCVNTGTIPS
60 70 80 90 100
KTLREAVLYL TGMNQRELYG ASYRVKDRIT PADLLARTQH VIGKEVDVVR
110 120 130 140 150
NQLMRNRVDL IVGHGRFIDP HTILVEDQAR REKTTVTGDY IIIATGTRPA
160 170 180 190 200
RPSGVEFDEE RVLDSDGILD LKSLPSSMVV VGAGVIGIEY ASMFAALGTK
210 220 230 240 250
VTVVEKRDNM LDFCDPEVVE ALKFHLRDLA VTFRFGEEVT AVDVGSAGTV
260 270 280 290 300
TTLASGKQIP AETVMYSAGR QGQTDHLDLH NAGLEVQGRG RIFVDDRFQT
310 320 330 340 350
KVDHIYAVGD VIGFPALAAT SMEQGRLAAY HAFGEPTDGI TELQPIGIYS
360 370 380 390 400
IPEVSYVGAT EVELTKSSIP YEVGVARYRE LARGQIAGDS YGMLKLLVST
410 420 430 440 450
EDLKLLGVHI FGTSATEMVH IGQAVMGCGG SVEYLVDAVF NYPTFSEAYK
460
NAALDVMNKM RALNQFRR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP45511.1 |
PIRi | D70532 |
RefSeqi | NP_217229.1, NC_000962.3 WP_003900556.1, NZ_NVQJ01000017.1 |
Genome annotation databases
EnsemblBacteriai | CCP45511; CCP45511; Rv2713 |
GeneIDi | 887355 |
KEGGi | mtu:Rv2713 mtv:RVBD_2713 |
PATRICi | fig|83332.111.peg.3018 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP45511.1 |
PIRi | D70532 |
RefSeqi | NP_217229.1, NC_000962.3 WP_003900556.1, NZ_NVQJ01000017.1 |
3D structure databases
SMRi | P9WHH5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv2713 |
Proteomic databases
PaxDbi | P9WHH5 |
PRIDEi | P9WHH5 |
Genome annotation databases
EnsemblBacteriai | CCP45511; CCP45511; Rv2713 |
GeneIDi | 887355 |
KEGGi | mtu:Rv2713 mtv:RVBD_2713 |
PATRICi | fig|83332.111.peg.3018 |
Organism-specific databases
TubercuListi | Rv2713 |
Phylogenomic databases
eggNOGi | ENOG4105DX1 Bacteria COG1249 LUCA |
KOi | K00322 |
OMAi | SGHAAWH |
PhylomeDBi | P9WHH5 |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-6961-MONOMER |
Family and domain databases
Gene3Di | 3.30.390.30, 1 hit 3.50.50.60, 2 hits |
HAMAPi | MF_00247 SthA, 1 hit |
InterProi | View protein in InterPro IPR036188 FAD/NAD-bd_sf IPR023753 FAD/NAD-binding_dom IPR016156 FAD/NAD-linked_Rdtase_dimer_sf IPR001100 Pyr_nuc-diS_OxRdtase IPR004099 Pyr_nucl-diS_OxRdtase_dimer IPR022962 STH |
Pfami | View protein in Pfam PF07992 Pyr_redox_2, 1 hit PF02852 Pyr_redox_dim, 1 hit |
PIRSFi | PIRSF000350 Mercury_reductase_MerA, 1 hit |
SUPFAMi | SSF51905 SSF51905, 1 hit SSF55424 SSF55424, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STHA_MYCTU | |
Accessioni | P9WHH5Primary (citable) accession number: P9WHH5 Secondary accession number(s): L0TAN4, O07212, P66006 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | November 13, 2019 | |
This is version 39 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names