UniProtKB - P9WGW1 (RUVB_MYCTU)
Protein
Holliday junction ATP-dependent DNA helicase RuvB
Gene
ruvB
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.UniRule annotation
Catalytic activityi
- EC:3.6.4.12UniRule annotation
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 63 – 70 | ATPUniRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- DNA binding Source: InterPro
- four-way junction helicase activity Source: UniProtKB-UniRule
GO - Biological processi
- DNA recombination Source: UniProtKB-UniRule
- DNA repair Source: UniProtKB-UniRule
- SOS response Source: UniProtKB-UniRule
Keywordsi
Molecular function | Helicase, Hydrolase |
Biological process | DNA damage, DNA recombination, DNA repair, SOS response |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-6834-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Holliday junction ATP-dependent DNA helicase RuvBUniRule annotation (EC:3.6.4.12UniRule annotation) |
Gene namesi | Name:ruvBUniRule annotation Ordered Locus Names:Rv2592c ORF Names:MTCY227.09 |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv2592c |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000165562 | 1 – 344 | Holliday junction ATP-dependent DNA helicase RuvBAdd BLAST | 344 |
Proteomic databases
PaxDbi | P9WGW1 |
PRIDEi | P9WGW1 |
Interactioni
Subunit structurei
Forms a complex with RuvA.
UniRule annotationProtein-protein interaction databases
STRINGi | 83332.Rv2592c |
Family & Domainsi
Sequence similaritiesi
Belongs to the RuvB family.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG4105CKJ Bacteria COG2255 LUCA |
KOi | K03551 |
OMAi | DEIHRMS |
PhylomeDBi | P9WGW1 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
HAMAPi | MF_00016 DNA_helic_RuvB, 1 hit |
InterProi | View protein in InterPro IPR003593 AAA+_ATPase IPR041445 AAA_lid_4 IPR004605 DNA_helicase_Holl-junc_RuvB IPR027417 P-loop_NTPase IPR008824 RuvB-like_N IPR008823 RuvB_C IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf |
PANTHERi | PTHR42848 PTHR42848, 1 hit |
Pfami | View protein in Pfam PF17864 AAA_lid_4, 1 hit PF05491 RuvB_C, 1 hit PF05496 RuvB_N, 1 hit |
SMARTi | View protein in SMART SM00382 AAA, 1 hit |
SUPFAMi | SSF46785 SSF46785, 1 hit SSF52540 SSF52540, 1 hit |
TIGRFAMsi | TIGR00635 ruvB, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WGW1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTERSDRDVS PALTVGEGDI DVSLRPRSLR EFIGQPRVRE QLQLVIEGAK
60 70 80 90 100
NRGGTPDHIL LSGPPGLGKT SLAMIIAAEL GSSLRVTSGP ALERAGDLAA
110 120 130 140 150
MLSNLVEHDV LFIDEIHRIA RPAEEMLYLA MEDFRVDVVV GKGPGATSIP
160 170 180 190 200
LEVAPFTLVG ATTRSGALTG PLRDRFGFTA HMDFYEPAEL ERVLARSAGI
210 220 230 240 250
LGIELGADAG AEIARRSRGT PRIANRLLRR VRDFAEVRAD GVITRDVAKA
260 270 280 290 300
ALEVYDVDEL GLDRLDRAVL SALTRSFGGG PVGVSTLAVA VGEEAATVEE
310 320 330 340
VCEPFLVRAG MVARTPRGRV ATALAWTHLG MTPPVGASQP GLFE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP45388.1 |
PIRi | G70726 |
RefSeqi | NP_217108.1, NC_000962.3 WP_003413416.1, NZ_NVQJ01000023.1 |
Genome annotation databases
EnsemblBacteriai | CCP45388; CCP45388; Rv2592c |
GeneIDi | 888173 |
KEGGi | mtu:Rv2592c mtv:RVBD_2592c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP45388.1 |
PIRi | G70726 |
RefSeqi | NP_217108.1, NC_000962.3 WP_003413416.1, NZ_NVQJ01000023.1 |
3D structure databases
SMRi | P9WGW1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv2592c |
Proteomic databases
PaxDbi | P9WGW1 |
PRIDEi | P9WGW1 |
Genome annotation databases
EnsemblBacteriai | CCP45388; CCP45388; Rv2592c |
GeneIDi | 888173 |
KEGGi | mtu:Rv2592c mtv:RVBD_2592c |
Organism-specific databases
TubercuListi | Rv2592c |
Phylogenomic databases
eggNOGi | ENOG4105CKJ Bacteria COG2255 LUCA |
KOi | K03551 |
OMAi | DEIHRMS |
PhylomeDBi | P9WGW1 |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-6834-MONOMER |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
HAMAPi | MF_00016 DNA_helic_RuvB, 1 hit |
InterProi | View protein in InterPro IPR003593 AAA+_ATPase IPR041445 AAA_lid_4 IPR004605 DNA_helicase_Holl-junc_RuvB IPR027417 P-loop_NTPase IPR008824 RuvB-like_N IPR008823 RuvB_C IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf |
PANTHERi | PTHR42848 PTHR42848, 1 hit |
Pfami | View protein in Pfam PF17864 AAA_lid_4, 1 hit PF05491 RuvB_C, 1 hit PF05496 RuvB_N, 1 hit |
SMARTi | View protein in SMART SM00382 AAA, 1 hit |
SUPFAMi | SSF46785 SSF46785, 1 hit SSF52540 SSF52540, 1 hit |
TIGRFAMsi | TIGR00635 ruvB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RUVB_MYCTU | |
Accessioni | P9WGW1Primary (citable) accession number: P9WGW1 Secondary accession number(s): L0TCV1, P66753, Q50629 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | September 18, 2019 | |
This is version 31 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names