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Entry version 39 (16 Oct 2019)
Sequence version 1 (16 Apr 2014)
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Protein

Phenylalanine--tRNA ligase beta subunit

Gene

pheT

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Was identified as a high-confidence drug target.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per tetramer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi467MagnesiumBy similarity1
Metal bindingi473Magnesium; via carbonyl oxygenBy similarity1
Metal bindingi476MagnesiumBy similarity1
Metal bindingi477MagnesiumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase, RNA-binding, tRNA-binding
Biological processProtein biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MTBH37RV:G185E-5840-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phenylalanine--tRNA ligase beta subunit (EC:6.1.1.20)
Alternative name(s):
Phenylalanyl-tRNA synthetase beta subunit
Short name:
PheRS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pheT
Ordered Locus Names:Rv1650
ORF Names:MTCY06H11.15
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83332 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001584 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

Organism-specific databases

Mycobacterium tuberculosis strain H37Rv genome database

More...
TubercuListi
Rv1650

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001269161 – 831Phenylalanine--tRNA ligase beta subunitAdd BLAST831

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P9WFU1

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Tetramer of two alpha and two beta subunits.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
83332.Rv1650

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P9WFU1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini44 – 155tRNA-bindingAdd BLAST112
Domaini414 – 489B5Add BLAST76
Domaini737 – 830FDX-ACBAdd BLAST94

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105C6A Bacteria
COG0072 LUCA
COG0073 LUCA

KEGG Orthology (KO)

More...
KOi
K01890

Identification of Orthologs from Complete Genome Data

More...
OMAi
ISYNWLK

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P9WFU1

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00769 PheRS_beta_core, 1 hit
cd02796 tRNA_bind_bactPheRS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.380, 1 hit
3.50.40.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00283 Phe_tRNA_synth_beta1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005146 B3/B4_tRNA-bd
IPR009061 DNA-bd_dom_put_sf
IPR005121 Fdx_antiC-bd
IPR036690 Fdx_antiC-bd_sf
IPR012340 NA-bd_OB-fold
IPR004532 Phe-tRNA-ligase_IIc_bsu
IPR020825 Phe-tRNA_synthase_B3/B4
IPR041616 PheRS_beta_core
IPR002547 tRNA-bd_dom
IPR033714 tRNA_bind_bactPheRS
IPR005147 tRNA_synthase_B5-dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03483 B3_4, 1 hit
PF03484 B5, 1 hit
PF03147 FDX-ACB, 1 hit
PF01588 tRNA_bind, 1 hit
PF17759 tRNA_synthFbeta, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00873 B3_4, 1 hit
SM00874 B5, 1 hit
SM00896 FDX-ACB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46955 SSF46955, 1 hit
SSF50249 SSF50249, 1 hit
SSF54991 SSF54991, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00472 pheT_bact, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51483 B5, 1 hit
PS51447 FDX_ACB, 1 hit
PS50886 TRBD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P9WFU1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLPYSWLRE VVAVGASGWD VTPGELEQTL LRIGHEVEEV IPLGPVDGPV
60 70 80 90 100
TVGRVADIEE LTGYKKPIRA CAVDIGDRQY REIICGATNF AVGDLVVVAL
110 120 130 140 150
PGATLPGGFT ISARKAYGRN SDGMICSAAE LNLGADHSGI LVLPPGAAEP
160 170 180 190 200
GADGAGVLGL DDVVFHLAIT PDRGYCMSVR GLARELACAY DLDFVDPASN
210 220 230 240 250
SRVPPLPIEG PAWPLTVQPE TGVRRFALRP VIGIDPAAVS PWWLQRRLLL
260 270 280 290 300
CGIRATCPAV DVTNYVMLEL GHPMHAHDRN RISGTLGVRF ARSGETAVTL
310 320 330 340 350
DGIERKLDTA DVLIVDDAAT AAIGGVMGAA STEVRADSTD VLLEAAIWDP
360 370 380 390 400
AAVSRTQRRL HLPSEAARRY ERTVDPAISV AALDRCARLL ADIAGGEVSP
410 420 430 440 450
TLTDWRGDPP CDDWSPPPIR MGVDVPDRIA GVAYPQGTTA RRLAQIGAVV
460 470 480 490 500
THDGDTLTVT PPSWRPDLRQ PADLVEEVLR LEGLEVIPSV LPPAPAGRGL
510 520 530 540 550
TAGQQRRRTI GRSLALSGYV EILPTPFLPA GVFDLWGLEA DDSRRMTTRV
560 570 580 590 600
LNPLEADRPQ LATTLLPALL EALVRNVSRG LVDVALFAIA QVVQPTEQTR
610 620 630 640 650
GVGLIPVDRR PTDDEIAMLD ASLPRQPQHV AAVLAGLREP RGPWGPGRPV
660 670 680 690 700
EAADAFEAVR IIARASRVDV TLRPAQYLPW HPGRCAQVFV GESSVGHAGQ
710 720 730 740 750
LHPAVIERSG LPKGTCAVEL NLDAIPCSAP LPAPRVSPYP AVFQDVSLVV
760 770 780 790 800
AADIPAQAVA DAVRAGAGDL LEDIALFDVF TGPQIGEHRK SLTFALRFRA
810 820 830
PDRTLTEDDA SAARDAAVQS AAERVGAVLR G
Length:831
Mass (Da):88,374
Last modified:April 16, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9BE010F0FA3485B2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP44415.1

Protein sequence database of the Protein Information Resource

More...
PIRi
E70620

NCBI Reference Sequences

More...
RefSeqi
NP_216166.1, NC_000962.3
WP_003901220.1, NZ_NVQJ01000016.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CCP44415; CCP44415; Rv1650

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
885283

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mtu:Rv1650
mtv:RVBD_1650

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP44415.1
PIRiE70620
RefSeqiNP_216166.1, NC_000962.3
WP_003901220.1, NZ_NVQJ01000016.1

3D structure databases

SMRiP9WFU1
ModBaseiSearch...

Protein-protein interaction databases

STRINGi83332.Rv1650

Proteomic databases

PaxDbiP9WFU1

Genome annotation databases

EnsemblBacteriaiCCP44415; CCP44415; Rv1650
GeneIDi885283
KEGGimtu:Rv1650
mtv:RVBD_1650

Organism-specific databases

TubercuListiRv1650

Phylogenomic databases

eggNOGiENOG4105C6A Bacteria
COG0072 LUCA
COG0073 LUCA
KOiK01890
OMAiISYNWLK
PhylomeDBiP9WFU1

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-5840-MONOMER

Family and domain databases

CDDicd00769 PheRS_beta_core, 1 hit
cd02796 tRNA_bind_bactPheRS, 1 hit
Gene3Di3.30.70.380, 1 hit
3.50.40.10, 1 hit
HAMAPiMF_00283 Phe_tRNA_synth_beta1, 1 hit
InterProiView protein in InterPro
IPR005146 B3/B4_tRNA-bd
IPR009061 DNA-bd_dom_put_sf
IPR005121 Fdx_antiC-bd
IPR036690 Fdx_antiC-bd_sf
IPR012340 NA-bd_OB-fold
IPR004532 Phe-tRNA-ligase_IIc_bsu
IPR020825 Phe-tRNA_synthase_B3/B4
IPR041616 PheRS_beta_core
IPR002547 tRNA-bd_dom
IPR033714 tRNA_bind_bactPheRS
IPR005147 tRNA_synthase_B5-dom
PfamiView protein in Pfam
PF03483 B3_4, 1 hit
PF03484 B5, 1 hit
PF03147 FDX-ACB, 1 hit
PF01588 tRNA_bind, 1 hit
PF17759 tRNA_synthFbeta, 1 hit
SMARTiView protein in SMART
SM00873 B3_4, 1 hit
SM00874 B5, 1 hit
SM00896 FDX-ACB, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
SSF50249 SSF50249, 1 hit
SSF54991 SSF54991, 1 hit
TIGRFAMsiTIGR00472 pheT_bact, 1 hit
PROSITEiView protein in PROSITE
PS51483 B5, 1 hit
PS51447 FDX_ACB, 1 hit
PS50886 TRBD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYFB_MYCTU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P9WFU1
Secondary accession number(s): L0T8W1, P94985
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: October 16, 2019
This is version 39 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
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