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Entry version 110 (18 Sep 2019)
Sequence version 2 (01 Aug 1998)
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Protein

Alpha-(1->3)-arabinofuranosyltransferase

Gene

aftD

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. Catalyzes the addition of an arabinofuranosyl (Araf) residue from the sugar donor decaprenyl-phospho-arabinose (DPA) on the C-3 of an alpha-(1->5)-linked Araf from the arabinan backbone of AG.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Adds an alpha-D-arabinofuranosyl group from trans,octacis-decaprenylphospho-beta-D-arabinofuranose at the 3-O-position of an alpha-(1->5)-arabinofuranan chain attached to a beta-(1->5)-galactofuranan chain. EC:2.4.2.47

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: cell wall polysaccharide biosynthesis

This protein is involved in the pathway cell wall polysaccharide biosynthesis, which is part of Cell wall biogenesis.
View all proteins of this organism that are known to be involved in the pathway cell wall polysaccharide biosynthesis and in Cell wall biogenesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MTBH37RV:G185E-4356-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00963

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-(1->3)-arabinofuranosyltransferase (EC:2.4.2.47)
Alternative name(s):
Arabinofuranan 3-O-arabinosyltransferase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:aftD
Ordered Locus Names:Rv0236c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83332 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001584 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

Organism-specific databases

Mycobacterium tuberculosis strain H37Rv genome database

More...
TubercuListi
Rv0236c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Transmembranei215 – 235HelicalSequence analysisAdd BLAST21
Transmembranei282 – 302HelicalSequence analysisAdd BLAST21
Transmembranei314 – 334HelicalSequence analysisAdd BLAST21
Transmembranei401 – 421HelicalSequence analysisAdd BLAST21
Transmembranei1256 – 1276HelicalSequence analysisAdd BLAST21
Transmembranei1297 – 1317HelicalSequence analysisAdd BLAST21
Transmembranei1338 – 1358HelicalSequence analysisAdd BLAST21
Transmembranei1369 – 1389HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 30Sequence analysisAdd BLAST30
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000042058231 – 1400Alpha-(1->3)-arabinofuranosyltransferaseAdd BLAST1370

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P96419

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
83332.Rv0236c

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini700 – 883F5/8 type CPROSITE-ProRule annotationAdd BLAST184

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG41073B4 Bacteria
ENOG410YR9E LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000044932

KEGG Orthology (KO)

More...
KOi
K16648

Identification of Orthologs from Complete Genome Data

More...
OMAi
AYGYFFP

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P96419

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021798 AftD
IPR000421 FA58C
IPR008979 Galactose-bd-like_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11847 DUF3367, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49785 SSF49785, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50022 FA58C_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P96419-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPLSRKWLP VVGAVALALT FAQSPGQVSP DTKLDLTANP LRFLARATNL
60 70 80 90 100
WNSDLPFGQA QNQAYGYLFP HGTFFVIGHL LGVPGWVTQR LWWAVLLTVG
110 120 130 140 150
FWGLLRVAEA LGVGGPSSRV VGAVAFALSP RVLTTLGSIS SETLPMMLAP
160 170 180 190 200
WVLLPTILAL RGTSGRSVRA LAAQAGLAVA LMGAVNAIAT LAGCLPAVIW
210 220 230 240 250
WACHRPNRLW WRYTAWWLLA MALATLWWVM ALTQLHGVSP PFLDFIESSG
260 270 280 290 300
VTTQWSSLVE VLRGTDSWTP FVAPNATAGA PLVTGSAAIL GTCLVAAAGL
310 320 330 340 350
AGLTSPAMPA RGRLVTMLLV GVVLLAVGHR GGLASPVAHP VQAFLDAAGT
360 370 380 390 400
PLRNVHKVGP VIRLPLVLGL AQLLSRVPLP GSAPRPAWLR AFAHPERDKR
410 420 430 440 450
VAVAVVALTA LMVSTSLAWT GRVAPPGTFG ALPQYWQEAA DWLRTHHAAT
460 470 480 490 500
PTPGRVLVVP GAPFATQVWG TSHDEPLQVL GDGPWGVRDS IPLTPPQTIR
510 520 530 540 550
ALDSVQRLFA AGRPSAGLAD TLARQGISYV LVRNDLDPET SRSARPILLH
560 570 580 590 600
RSIAGSPGLA KLAEFGAPVG PDPLAGFVND SGLRPRYPAI EIYRVSAPAN
610 620 630 640 650
PGAPYFAATD QLARVDGGPE VLLRLDERRR LQGQPPLGPV LMTADARAAG
660 670 680 690 700
LPVPQVAVTD TPVARETDYG RVDHHSSAIR APGDARHTYN RVPDYPVPGA
710 720 730 740 750
EPVVGGWTGG RITVSSSSAD ATAMPDVAPA SAPAAAVDGD PATAWVSNAL
760 770 780 790 800
QAAVGQWLQV DFDRPVTNAV VTLTPSATAV GAQVRRILIE TVNGSTTLRF
810 820 830 840 850
DEAGKPLTAA LPYGETPWVR FTAAATDDGS AGVQFGITDL AITQYDASGF
860 870 880 890 900
AHPVQLRHTV LVPGPPPGSA IAGWDLGSEL LGRPGCAPGP DGVRCAASMA
910 920 930 940 950
LAPEEPANLS RTLTVPRPVS VTPMVWVRPR QGPKLADLIA APSTTRASGD
960 970 980 990 1000
SDLVDILGSA YAAADGDPAT AWTAPQRVVQ HKTPPTLTLT LPRPTVVTGL
1010 1020 1030 1040 1050
RLAASRSMLP AHPTVVAINL GDGPQVRQLQ VGELTTLWLH PRVTDTVSVS
1060 1070 1080 1090 1100
LLDWDDVIDR NALGFDQLKP PGLAEVVVLS AGGAPIAPAD AARNRARALT
1110 1120 1130 1140 1150
VDCDHGPVVA VAGRFVHTSI RTTVGALLDG EPVAALPCER EPIALPAGQQ
1160 1170 1180 1190 1200
ELLISPGAAF VVDGAQLSTP GAGLSSATVT SAETGAWGPT HREVRVPESA
1210 1220 1230 1240 1250
TSRVLVVPES INSGWVARTS TGARLTPIAV NGWQQAWVVP AGNPGTITLT
1260 1270 1280 1290 1300
FAPNSLYRAS LAIGLALLPL LALLAFWRTG RRQLADRPTP PWRPGAWAAA
1310 1320 1330 1340 1350
GVLAAGAVIA SIAGVMVMGT ALGVRYALRR RERLRDRVTV GLAAGGLILA
1360 1370 1380 1390 1400
GAALSRHPWR SVDGYAGNWA SVQLLALISV SVVAASVVAT SESRGQDRMQ
Length:1,400
Mass (Da):146,280
Last modified:August 1, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0EBC23F02DE74B59
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP42964.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B70963

NCBI Reference Sequences

More...
RefSeqi
NP_214750.1, NC_000962.3

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CCP42964; CCP42964; Rv0236c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
886707

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mtu:Rv0236c
mtv:RVBD_0236c

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|83332.111.peg.268

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP42964.1
PIRiB70963
RefSeqiNP_214750.1, NC_000962.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi83332.Rv0236c

Proteomic databases

PaxDbiP96419

Genome annotation databases

EnsemblBacteriaiCCP42964; CCP42964; Rv0236c
GeneIDi886707
KEGGimtu:Rv0236c
mtv:RVBD_0236c
PATRICifig|83332.111.peg.268

Organism-specific databases

TubercuListiRv0236c

Phylogenomic databases

eggNOGiENOG41073B4 Bacteria
ENOG410YR9E LUCA
HOGENOMiHOG000044932
KOiK16648
OMAiAYGYFFP
PhylomeDBiP96419

Enzyme and pathway databases

UniPathwayiUPA00963
BioCyciMTBH37RV:G185E-4356-MONOMER

Family and domain databases

Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR021798 AftD
IPR000421 FA58C
IPR008979 Galactose-bd-like_sf
PfamiView protein in Pfam
PF11847 DUF3367, 1 hit
SUPFAMiSSF49785 SSF49785, 2 hits
PROSITEiView protein in PROSITE
PS50022 FA58C_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAFTD_MYCTU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P96419
Secondary accession number(s): L0T2X2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2013
Last sequence update: August 1, 1998
Last modified: September 18, 2019
This is version 110 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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