P72760 · CCMK1_SYNY3
- ProteinCarboxysome shell protein CcmK1
- GeneccmK1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids111 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
One of the shell proteins of the carboxysome, a polyhedral inclusion where RuBisCO (ribulose bisphosphate carboxylase, rbcL-rbcS) is sequestered. Assembles into hexamers which make sheets that form the facets of the polyhedral carboxysome. The hexamer central pore probably regulates metabolite flux.
Probably the major shell protein of the carboxysome, a polyhedral inclusion where RuBisCO (ribulose bisphosphate carboxylase, rbcL-rbcS) is sequestered. The central pore probably regulates metabolite flux (PubMed:18292340).
Hexamers make sheets that form the facets of the carboxysome (Probable) (PubMed:19844993).
Hexamers make sheets that form the facets of the carboxysome (Probable) (PubMed:19844993).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | carboxysome | |
Molecular Function | structural constituent of carboxysome shell | |
Biological Process | carbon fixation | |
Biological Process | photosynthesis |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameCarboxysome shell protein CcmK1
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Cyanobacteriota > Cyanophyceae > Synechococcales > Merismopediaceae > Synechocystis
Accessions
- Primary accessionP72760
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Note: This cyanobacterium makes beta-type carboxysomes (Probable). Forms walls in the polyhedral carboxysome (Probable).
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 92-111 | Alters hexamer layer packing. | ||||
Sequence: Missing |
PTM/Processing
Features
Showing features for initiator methionine, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Chain | PRO_0000201506 | 2-111 | Carboxysome shell protein CcmK1 | |||
Sequence: SIAVGMIETLGFPAVVEAADSMVKAARVTLVGYEKIGSGRVTVIVRGDVSEVQASVTAGIENIRRVNGGEVLSNHIIARPHENLEYVLPIRYTEAVEQFREIVNPSIIRR |
Proteomic databases
Interaction
Subunit
Homohexamer (PubMed:18292340, PubMed:19177356, PubMed:19844993, PubMed:24419393, PubMed:31603944).
Interacts with full-length CcmM (PubMed:17993516).
Forms mixed heterohexamers of all possible stoichiometries with CcmK2, which might form dodecamers. Only very weak interactions with CcmK3 and CcmK4 were seen (PubMed:31603944).
Interacts with CcmN and CcmO in the carboxysome (By similarity).
Interacts with full-length CcmM (PubMed:17993516).
Forms mixed heterohexamers of all possible stoichiometries with CcmK2, which might form dodecamers. Only very weak interactions with CcmK3 and CcmK4 were seen (PubMed:31603944).
Interacts with CcmN and CcmO in the carboxysome (By similarity).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 4-90 | BMC | ||||
Sequence: AVGMIETLGFPAVVEAADSMVKAARVTLVGYEKIGSGRVTVIVRGDVSEVQASVTAGIENIRRVNGGEVLSNHIIARPHENLEYVLP |
Domain
The tight homohexamer forms a pore with an opening of about 5.0 Angstroms in diameter which is positively charged. Sulfate ions are bound in one crystal form in both the pore and between hexamers which may represent metabolite flux. The C-terminal flexible tail, which is the most variable part of CcmK proteins, seems to be involved in packing of hexamers in layers.
Sequence similarities
Belongs to the bacterial microcompartments protein family. CcmK subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length111
- Mass (Da)12,102
- Last updated2007-01-23 v3
- Checksum4C3B3E207A600609
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BA000022 EMBL· GenBank· DDBJ | BAA16775.1 EMBL· GenBank· DDBJ | Genomic DNA |