ID CAS10_MYCTU Reviewed; 809 AA. AC P71629; L0TDG3; DT 11-JUL-2012, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1997, sequence version 1. DT 14-MAY-2014, entry version 73. DE RecName: Full=CRISPR-associated protein Cas10/Csm1; DE AltName: Full=CRISPR-associated protein Cas10/Csm1, subtype III-A/Mtube; GN Name=cas10; Synonyms=csm1; OrderedLocusNames=Rv2823c; OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Corynebacterineae; Mycobacteriaceae; Mycobacterium; OC Mycobacterium tuberculosis complex. OX NCBI_TaxID=83332; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 25618 / H37Rv; RX PubMed=9634230; DOI=10.1038/31159; RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., RA Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, RA Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., RA Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N., RA Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., RA Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., RA Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., RA Sulston J.E., Taylor K., Whitehead S., Barrell B.G.; RT "Deciphering the biology of Mycobacterium tuberculosis from the RT complete genome sequence."; RL Nature 393:537-544(1998). CC -!- FUNCTION: CRISPR (clustered regularly interspaced short CC palindromic repeat) is an adaptive immune system that provides CC protection against mobile genetic elements (viruses, transposable CC elements and conjugative plasmids). CRISPR clusters contain CC spacers, sequences complementary to antecedent mobile elements, CC and target invading nucleic acids. CRISPR clusters are transcribed CC and processed into CRISPR RNA (crRNA) (By similarity). CC -!- SIMILARITY: Belongs to the CRISPR-associated Cas10/Csm1 family. CC -!- SIMILARITY: Contains 1 GGDEF domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL123456; CCP45623.1; -; Genomic_DNA. DR PIR; B70692; B70692. DR RefSeq; NP_217339.1; NC_000962.3. DR RefSeq; YP_006516272.1; NC_018143.2. DR ProteinModelPortal; P71629; -. DR STRING; 83332.Rv2823c; -. DR PRIDE; P71629; -. DR EnsemblBacteria; CCP45623; CCP45623; Rv2823c. DR GeneID; 13317611; -. DR GeneID; 887735; -. DR KEGG; mtu:Rv2823c; -. DR KEGG; mtv:RVBD_2823c; -. DR PATRIC; 18154869; VBIMycTub87468_3148. DR TubercuList; Rv2823c; -. DR HOGENOM; HOG000220575; -. DR KO; K07016; -. DR OMA; IQDFIYN; -. DR OrthoDB; EOG632CZD; -. DR BioCyc; MTBRV:RV2823C-MONOMER; -. DR GO; GO:0005576; C:extracellular region; IDA:MTBBASE. DR GO; GO:0005886; C:plasma membrane; IDA:MTBBASE. DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW. DR InterPro; IPR013408; CRISPR-assoc_prot_Csm1. DR InterPro; IPR000160; GGDEF_dom. DR TIGRFAMs; TIGR02578; cas_TM1811_Csm1; 1. DR PROSITE; PS50887; GGDEF; 1. PE 3: Inferred from homology; KW Antiviral defense; Complete proteome; Reference proteome. FT CHAIN 1 809 CRISPR-associated protein Cas10/Csm1. FT /FTId=PRO_0000418224. FT DOMAIN 547 700 GGDEF. SQ SEQUENCE 809 AA; 90747 MW; E7328ED485D73531 CRC64; MNPQLIEAII GCLLHDIGKP VQRAALGYPG RHSAIGRAFM KKVWLRDSRN PSQFTDEVDE ADIGVSDRRI LDAISYHHSS ALRTAAENGR LAADAPAYIA YNIAAGTDRR KADSDDGHGA STWDPDTPLY SMFNRFGSGT ANLAFAPEML DDRKPINIPS PRRIEFDKDR YAAIVNKLKA ILVDLERSDT YLASLLNVLE ATLSFVPSST DASEVVDVSL FDHLKLTGAL GACIWHYLQA TGQSDFKSAL FDKQDTFYNE KAFLLTTFDV SGIQDFIYTI HSSGAAKMLR ARSFYLEMLT EHLIDELLAR VGLSRANLNY SGGGHAYLLL PNTESARKSV EQFEREANDW LLENFATRLF IATGSVPLAA NDLMRRPNES ASQASNRALR YSGLYRELSE QLSAKKLARY SADQLRELNS RDHDGQKGDR ECSVCHTVNR TVSADDEPKC SLCQALTAAS SQIQSESRRF LLISDGATKG LPLPFGATLT FCSRADADKA LQQPQTRRRY AKNKFFAGEC LGTGLWVGDY VAQMEFGDYV KRASGIARLG VLRLDVDNLG QAFTHGFMEQ GNGKFNTISR TAAFSRMLSL FFRQHINYVL ARPKLRPITG DDPARPREAT IIYSGGDDVF VVGAWDDVIE FGIELRERFH EFTQGKLTVS AGIGMFPDKY PISVMAREVG DLEDAAKSLP GKNGVALFDR EFTFGWDELL SKVIEEKYRH IADYFSGNEE RGMAFIYKLL ELLAERDDRI TKARWVYFLT RMRNPTGDTA PFQQFANRLH QWFQDPTDAK QLKTALHLYI YRTRKEESE //