P63208 · SKP1_HUMAN

  • Protein
    S-phase kinase-associated protein 1
  • Gene
    SKP1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2 (PubMed:25704143).
SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2. Core component of the Cul7-RING(FBXW8) ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:35982156).

Pathway

Protein modification; protein ubiquitination.

GO annotations

AspectTerm
Cellular Componentcentrosome
Cellular ComponentCul7-RING ubiquitin ligase complex
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentnucleoplasm
Cellular Componentnucleus
Cellular ComponentPcG protein complex
Cellular ComponentSCF ubiquitin ligase complex
Molecular Functionbeta-catenin binding
Molecular Functioncullin family protein binding
Molecular FunctionF-box domain binding
Molecular Functionmolecular function activator activity
Molecular Functionprotein domain specific binding
Molecular Functionubiquitin ligase complex scaffold activity
Molecular Functionubiquitin-like ligase-substrate adaptor activity
Biological Processchromatin remodeling
Biological Processmaintenance of protein location in nucleus
Biological Processpositive regulation of ubiquitin protein ligase activity
Biological Processproteasome-mediated ubiquitin-dependent protein catabolic process
Biological Processprotein K48-linked ubiquitination
Biological Processprotein monoubiquitination
Biological Processprotein polyubiquitination
Biological Processprotein ubiquitination
Biological ProcessSCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    S-phase kinase-associated protein 1
  • Alternative names
    • Cyclin-A/CDK2-associated protein p19 (p19A)
    • Organ of Corti protein 2 (OCP-2)
    • Organ of Corti protein II (OCP-II)
    • RNA polymerase II elongation factor-like protein
    • SIII

Gene names

    • Name
      SKP1
    • Synonyms
      EMC19, OCP2, SKP1A, TCEB1L

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P63208
  • Secondary accessions
    • D3DQ97
    • D3DQ98
    • P34991
    • Q8TAY2

Proteomes

Organism-specific databases

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 84 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Chemistry

    • DB06980(2S)-2-(1H-indol-3-yl)hexanoic acid
    • DB06981(2S)-2-(1H-indol-3-yl)pentanoic acid
    • DB06982(2S)-8-[(tert-butoxycarbonyl)amino]-2-(1H-indol-3-yl)octanoic acid
    • DB017501-naphthaleneacetic acid
    • DB07950Indoleacetic acid

Genetic variation databases

PTM/Processing

Features

Showing features for initiator methionine, chain, modified residue, cross-link.

TypeIDPosition(s)Description
Initiator methionine1Removed
ChainPRO_00001872512-163S-phase kinase-associated protein 1
Modified residue131Phosphothreonine
Cross-link142Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)

Post-translational modification

Undergoes autophagy-mediated degradation in the liver in a time-dependent manner.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

Interacts with KDM2B, forming heterodimers (PubMed:27568929).
The KDM2B-SKP1 heterodimeric complex interacts with the PCGF1-BCORL heterodimeric complex to form a homotetrameric polycomb repression complex 1 (PRC1.1) (PubMed:27568929).
Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein as substrate-specific subunit. Component of the SCF(FBXW11) complex containing FBXW11. Component of the SCF(SKP2) complex containing SKP2, in which it interacts directly with SKP1, SKP2 and RBX1. Component of the SCF(FBXW2) complex containing FBXW2. Component of the SCF(FBXO32) complex containing FBXO32. Component of the probable SCF(FBXO7) complex containing FBXO7. Component of the SCF(FBXO10) complex containing FBXO10. Component of the SCF(FBXO11) complex containing FBXO11. Component of the SCF(FBXO25) complex containing FBXO25. Component of the SCF(FBXO33) complex containing FBXO33. Component of the probable SCF(FBXO4) complex containing FBXO4. Component of the SCF(FBXO44) complex, composed of SKP1, CUL1 and FBXO44. Component of the SCF(BTRC) complex, composed of SKP1, CUL1 and BTRC. This complex binds phosphorylated NFKBIA. Part of a SCF complex consisting of CUL1, RBX1, SKP1 and FBXO2. Component of a SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2. Component of the SCF(FBXO17) complex, composed of SKP1, CUL1 and FBXO17. Component of the SCF(FBXO27) complex, composed of SKP1, CUL1 and FBXO27. Component of the SCF(CCNF) complex consisting of CUL1, RBX1, SKP1 and CCNF. Component of the SCF(FBXL3) complex composed of CUL1, SKP1, RBX1 and FBXL3. Component of the SCF(FBXL21) complex composed of CUL1, SKP1, RBX1 and FBXL21. Component of the SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Component of the SCF(FBXW7) composed of CUL1, SKP1, RBX1 and FBXW7 (PubMed:28727686).
Interacts with CEP68 (PubMed:25503564).
Interacts with NOTCH2 (PubMed:29149593).
Interacts with FBXW15 (By similarity).
The SKP1-KDM2A and SKP1-KDM2B complexes interact with UBB (PubMed:30033217).
Component of the Cul7-RING(FBXW8) complex consisting of CUL7, RBX1, SKP1 and FBXW8; within the complex interacts with FBXW8 (PubMed:35982156).
(Microbial infection) Interacts with vaccinia virus protein C9L.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P63208ANKRD36BP1 Q96IX93EBI-307486, EBI-744859
BINARY P63208APIP Q96GX93EBI-307486, EBI-359248
BINARY P63208ATXN1 P542536EBI-307486, EBI-930964
BINARY P63208BTRC Q9Y29724EBI-307486, EBI-307461
BINARY P63208CCNF P410029EBI-307486, EBI-1207574
BINARY P63208CDKN1A P389363EBI-307486, EBI-375077
BINARY P63208CUL1 Q1361620EBI-307486, EBI-359390
BINARY P63208FBXL12 Q9NXK810EBI-307486, EBI-719790
BINARY P63208FBXL14 Q8N1E66EBI-307486, EBI-6425532
BINARY P63208FBXL17 Q9UF5616EBI-307486, EBI-8835653
BINARY P63208FBXL2 Q9UKC99EBI-307486, EBI-724253
BINARY P63208FBXL20 Q96IG27EBI-307486, EBI-8835647
XENO P63208Fbxl21 Q8BFZ43EBI-307486, EBI-6898235
BINARY P63208FBXL22 Q6P0507EBI-307486, EBI-24224082
XENO P63208Fbxl3 Q8C4V43EBI-307486, EBI-1266589
BINARY P63208FBXL5 Q9UKA115EBI-307486, EBI-2692340
BINARY P63208FBXL6 Q8N5313EBI-307486, EBI-2322696
BINARY P63208FBXL8 Q96CD017EBI-307486, EBI-2321097
BINARY P63208FBXO11 Q86XK211EBI-307486, EBI-1047804
BINARY P63208FBXO17 Q96EF619EBI-307486, EBI-2510157
BINARY P63208FBXO2 Q9UK2214EBI-307486, EBI-4287196
BINARY P63208FBXO21 O9495210EBI-307486, EBI-311435
BINARY P63208FBXO22 Q8NEZ510EBI-307486, EBI-2510137
BINARY P63208FBXO25 Q8TCJ0-34EBI-307486, EBI-6262578
BINARY P63208FBXO27 Q8NI293EBI-307486, EBI-6425694
BINARY P63208FBXO28 Q9NVF714EBI-307486, EBI-740282
BINARY P63208FBXO3 Q9UK9912EBI-307486, EBI-2509901
BINARY P63208FBXO31 Q5XUX04EBI-307486, EBI-6162477
BINARY P63208FBXO33 Q7Z6M25EBI-307486, EBI-8555452
BINARY P63208FBXO4 Q9UKT519EBI-307486, EBI-960409
BINARY P63208FBXO43 Q4G1633EBI-307486, EBI-12053217
BINARY P63208FBXO44 Q9H4M38EBI-307486, EBI-2322644
BINARY P63208FBXO44 Q9H4M3-26EBI-307486, EBI-12104696
BINARY P63208FBXO46 Q6PJ617EBI-307486, EBI-2322982
BINARY P63208FBXO48 Q5FWF75EBI-307486, EBI-11961122
BINARY P63208FBXO5 Q9UKT48EBI-307486, EBI-852298
BINARY P63208FBXO6 Q9NRD19EBI-307486, EBI-3938499
BINARY P63208FBXO7 Q9Y3I111EBI-307486, EBI-1161222
BINARY P63208FBXO9 Q9UK975EBI-307486, EBI-2869927
BINARY P63208FBXO9 Q9UK97-23EBI-307486, EBI-11023199
BINARY P63208FBXW11 Q9UKB113EBI-307486, EBI-355189
BINARY P63208FBXW2 Q9UKT87EBI-307486, EBI-914727
BINARY P63208FBXW4 P577753EBI-307486, EBI-2372268
BINARY P63208FBXW5 Q969U67EBI-307486, EBI-741068
BINARY P63208FBXW7 Q969H011EBI-307486, EBI-359574
BINARY P63208FBXW8 Q8N3Y15EBI-307486, EBI-914770
BINARY P63208FBXW9 Q5XUX17EBI-307486, EBI-2322729
BINARY P63208KCTD9 Q7L2733EBI-307486, EBI-4397613
BINARY P63208KDM2A Q9Y2K76EBI-307486, EBI-765758
BINARY P63208KDM2B Q8NHM58EBI-307486, EBI-3955564
BINARY P63208LMO2 P257913EBI-307486, EBI-739696
BINARY P63208MEOX2 Q6FHY53EBI-307486, EBI-16439278
BINARY P63208MTUS1 Q9ULD2-33EBI-307486, EBI-18051665
BINARY P63208MYC Q149012EBI-307486, EBI-7982457
BINARY P63208PPP1CA P621364EBI-307486, EBI-357253
BINARY P63208SKP2 Q1330918EBI-307486, EBI-456291
BINARY P63208SKP2 Q13309-25EBI-307486, EBI-7791408
BINARY P63208SUGT1 Q9Y2Z0-22EBI-307486, EBI-10768076
BINARY P63208TTC21A A0A0B4J1Y23EBI-307486, EBI-10220701
BINARY P63208TTC9C Q8N5M413EBI-307486, EBI-2851213
BINARY P63208-1CCNF P410026EBI-307497, EBI-1207574
BINARY P63208-1FBXO11 Q86XK25EBI-307497, EBI-1047804
XENO P63208-1Fbxo2 Q80UW24EBI-307497, EBI-2314714
BINARY P63208-1FBXW5 Q969U6-13EBI-307497, EBI-16031873
BINARY P63208-1FBXW7 Q969H02EBI-307497, EBI-359574
BINARY P63208-1MED21 Q135035EBI-307497, EBI-394678
XENO P63208-1 Q6TVJ22EBI-307497, EBI-15718764
XENO P63208-1 Q6TVJ42EBI-307497, EBI-15718558
XENO P63208-1 Q6TVJ72EBI-307497, EBI-15718586
XENO P63208-1 Q6TVW25EBI-307497, EBI-15718527
BINARY P63208-1SKP2 Q13309-17EBI-307497, EBI-15490084
BINARY P63208-2SPRED1 Q7Z6993EBI-25930963, EBI-5235340
View interactors in UniProtKB
View CPX-2239 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region63-83Disordered
Region104-163Interaction with the F-box domain of F-box proteins

Sequence similarities

Belongs to the SKP1 family.

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

P63208-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    163
  • Mass (Da)
    18,658
  • Last updated
    2007-01-23 v2
  • Checksum
    C794D62AFB75528A
MPSIKLQSSDGEIFEVDVEIAKQSVTIKTMLEDLGMDDEGDDDPVPLPNVNAAILKKVIQWCTHHKDDPPPPEDDENKEKRTDDIPVWDQEFLKVDQGTLFELILAANYLDIKGLLDVTCKTVANMIKGKTPEEIRKTFNIKNDFTEEEEAQVRKENQWCEEK

P63208-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
E7ERH2E7ERH2_HUMANSKP1142
F8W8N3F8W8N3_HUMANSKP1158
E5RJR5E5RJR5_HUMANSKP1163
E5RK33E5RK33_HUMANSKP118
E5RGM3E5RGM3_HUMANSKP1102
E5RGM4E5RGM4_HUMANSKP141
E5RHM3E5RHM3_HUMANSKP139

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_007555154-163in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U33760
EMBL· GenBank· DDBJ
AAC50241.1
EMBL· GenBank· DDBJ
mRNA
Z47087
EMBL· GenBank· DDBJ
CAA87392.1
EMBL· GenBank· DDBJ
mRNA
CH471062
EMBL· GenBank· DDBJ
EAW62270.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471062
EMBL· GenBank· DDBJ
EAW62271.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471062
EMBL· GenBank· DDBJ
EAW62272.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471062
EMBL· GenBank· DDBJ
EAW62276.1
EMBL· GenBank· DDBJ
Genomic DNA
BC009839
EMBL· GenBank· DDBJ
AAH09839.1
EMBL· GenBank· DDBJ
mRNA
BC020798
EMBL· GenBank· DDBJ
AAH20798.1
EMBL· GenBank· DDBJ
mRNA
BC025673
EMBL· GenBank· DDBJ
AAH25673.1
EMBL· GenBank· DDBJ
mRNA
BC065730
EMBL· GenBank· DDBJ
AAH65730.1
EMBL· GenBank· DDBJ
mRNA
U37558
EMBL· GenBank· DDBJ
AAA79202.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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