P62854 · RS26_HUMAN
- ProteinSmall ribosomal subunit protein eS26
- GeneRPS26
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids115 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Component of the small ribosomal subunit (PubMed:23636399, PubMed:25901680, PubMed:25957688).
The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957688).
The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957688).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytoplasmic side of rough endoplasmic reticulum membrane | |
Cellular Component | cytosol | |
Cellular Component | cytosolic small ribosomal subunit | |
Cellular Component | extracellular exosome | |
Cellular Component | membrane | |
Cellular Component | nucleoplasm | |
Cellular Component | ribosome | |
Cellular Component | small ribosomal subunit | |
Cellular Component | synapse | |
Molecular Function | cadherin binding | |
Molecular Function | mRNA binding | |
Molecular Function | RNA binding | |
Molecular Function | structural constituent of ribosome | |
Biological Process | cytoplasmic translation | |
Biological Process | negative regulation of RNA splicing | |
Biological Process | translation |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSmall ribosomal subunit protein eS26
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP62854
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Detected on cytosolic polysomes (PubMed:25957688).
Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).
Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).
Keywords
- Cellular component
Disease & Variants
Involvement in disease
Diamond-Blackfan anemia 10 (DBA10)
- Note
- DescriptionA form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
- See alsoMIM:613309
Natural variants in DBA10
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_063580 | 33 | D>N | in DBA10; dbSNP:rs267607023 | |
VAR_063581 | 115 | M>T | in DBA10 |
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Natural variant | VAR_063580 | 33 | in DBA10; dbSNP:rs267607023 | ||
Natural variant | VAR_063581 | 115 | in DBA10 | ||
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 91 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for initiator methionine, chain, modified residue, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | ||
---|---|---|---|---|---|---|
Initiator methionine | 1 | UniProt | Removed | |||
Chain | PRO_0000204509 | 2-115 | UniProt | Small ribosomal subunit protein eS26 | ||
Modified residue | 54 | UniProt | Phosphoserine | |||
Modified residue (large scale data) | 54 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 57 | PRIDE | Phosphoserine | |||
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Subunit
Component of the 40S small ribosomal subunit.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | IntAct | |
---|---|---|---|---|---|
BINARY | P62854 | OTX2 P32243-2 | 3 | EBI-353438, EBI-9087860 | |
BINARY | P62854 | SDCBP O00560 | 3 | EBI-353438, EBI-727004 | |
BINARY | P62854 | TSR2 Q969E8 | 17 | EBI-353438, EBI-746981 |
Complex viewer
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 85-99 | Basic and acidic residues | |||
Region | 85-115 | Disordered | |||
Compositional bias | 101-115 | Pro residues | |||
Sequence similarities
Belongs to the eukaryotic ribosomal protein eS26 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length115
- Mass (Da)13,015
- Last updated2007-01-23 v3
- MD5 ChecksumF36A1CA722713CCA71D35723C920F54E
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 78 | in Ref. 2; CAA54808 | |||
Compositional bias | 85-99 | Basic and acidic residues | |||
Compositional bias | 101-115 | Pro residues | |||
Sequence conflict | 109 | in Ref. 1; CAA49345 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X69654 EMBL· GenBank· DDBJ | CAA49345.1 EMBL· GenBank· DDBJ | mRNA | ||
X77770 EMBL· GenBank· DDBJ | CAA54808.1 EMBL· GenBank· DDBJ | mRNA | ||
X79236 EMBL· GenBank· DDBJ | CAA55818.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U41448 EMBL· GenBank· DDBJ | AAC26987.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC002604 EMBL· GenBank· DDBJ | AAH02604.1 EMBL· GenBank· DDBJ | mRNA | ||
BC015832 EMBL· GenBank· DDBJ | AAH15832.1 EMBL· GenBank· DDBJ | mRNA | ||
BC070220 EMBL· GenBank· DDBJ | AAH70220.1 EMBL· GenBank· DDBJ | mRNA | ||
BC105276 EMBL· GenBank· DDBJ | AAI05277.1 EMBL· GenBank· DDBJ | mRNA | ||
BC105798 EMBL· GenBank· DDBJ | AAI05799.1 EMBL· GenBank· DDBJ | mRNA |