P62847 · RS24_HUMAN
- ProteinSmall ribosomal subunit protein eS24
- GeneRPS24
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids133 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Component of the small ribosomal subunit (PubMed:23636399).
The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399).
Required for processing of pre-rRNA and maturation of 40S ribosomal subunits (PubMed:18230666).
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797).
The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399).
Required for processing of pre-rRNA and maturation of 40S ribosomal subunits (PubMed:18230666).
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | cytosolic ribosome | |
Cellular Component | cytosolic small ribosomal subunit | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | membrane | |
Cellular Component | nucleolus | |
Cellular Component | nucleoplasm | |
Cellular Component | nucleus | |
Cellular Component | small ribosomal subunit | |
Cellular Component | small-subunit processome | |
Molecular Function | RNA binding | |
Molecular Function | structural constituent of ribosome | |
Molecular Function | translation initiation factor binding | |
Biological Process | cytoplasmic translation | |
Biological Process | erythrocyte homeostasis | |
Biological Process | ribosomal small subunit biogenesis | |
Biological Process | rRNA processing | |
Biological Process | translation |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSmall ribosomal subunit protein eS24
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP62847
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Involvement in disease
Diamond-Blackfan anemia 3 (DBA3)
- Note
- DescriptionA form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of developing leukemia. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
- See alsoMIM:610629
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 124 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue, chain, cross-link, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | ||
---|---|---|---|---|---|---|
Modified residue | 1 | UniProt | N-acetylmethionine | |||
Chain | PRO_0000137623 | 1-133 | UniProt | Small ribosomal subunit protein eS24 | ||
Modified residue | 9 | UniProt | Phosphothreonine | |||
Cross-link | 37 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | |||
Modified residue (large scale data) | 76 | PRIDE | Phosphotyrosine | |||
Modified residue (large scale data) | 81 | PRIDE | Phosphotyrosine | |||
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Mature tissues, such as adult brain, skeletal muscle, heart, and kidney, express low levels, whereas tissues and organs with significant populations of proliferating cells, such as fetal brain, placenta, bone marrow, and various glandular organs, contain significantly higher levels.
Gene expression databases
Organism-specific databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 92-133 | Disordered | |||
Compositional bias | 94-118 | Basic residues | |||
Sequence similarities
Belongs to the eukaryotic ribosomal protein eS24 family.
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 4 isoforms produced by Alternative splicing.
P62847-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length133
- Mass (Da)15,423
- Last updated2004-08-16 v1
- MD5 ChecksumBC633404322CF5D5D93506A98D33F4BE
P62847-2
- Name2
- Differences from canonical
- 131-133: Missing
P62847-3
- Name3
- Differences from canonical
- 131-133: PKE → KK
P62847-4
- Name4
- Differences from canonical
- 131-133: PKE → MRELGLGVQALGRISQEERCTDVKNSKARESRGVVWQVEVPGPWSVWTCGRLRRGCGKYLQVAVTWRKTENREQCCQACLLERALVRNGAFMSPASPAPAGSPHPVDGDLVLHLPEALSATLTLSPHIQAINKSFGPFFEIHQESSCFSPPSCLSGLGH
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2R8Y8A0 | A0A2R8Y8A0_HUMAN | RPS24 | 90 | ||
A0A2R8Y849 | A0A2R8Y849_HUMAN | RPS24 | 131 | ||
E7ETK0 | E7ETK0_HUMAN | RPS24 | 131 | ||
A0A2R8YD14 | A0A2R8YD14_HUMAN | RPS24 | 165 |
Features
Showing features for compositional bias, alternative sequence.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 94-118 | Basic residues | |||
Alternative sequence | VSP_005724 | 131-133 | in isoform 2 | ||
Alternative sequence | VSP_039113 | 131-133 | in isoform 3 | ||
Alternative sequence | VSP_045672 | 131-133 | in isoform 4 | ||
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M31520 EMBL· GenBank· DDBJ | AAA36588.1 EMBL· GenBank· DDBJ | mRNA | ||
U12202 EMBL· GenBank· DDBJ | AAB08007.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U12202 EMBL· GenBank· DDBJ | AAB08006.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX336465 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
AK311776 EMBL· GenBank· DDBJ | BAG34719.1 EMBL· GenBank· DDBJ | mRNA | ||
AK311910 EMBL· GenBank· DDBJ | BAG34851.1 EMBL· GenBank· DDBJ | mRNA | ||
BX537975 EMBL· GenBank· DDBJ | CAD97939.1 EMBL· GenBank· DDBJ | mRNA | ||
AL512628 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471083 EMBL· GenBank· DDBJ | EAW54623.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471083 EMBL· GenBank· DDBJ | EAW54625.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC000523 EMBL· GenBank· DDBJ | AAH00523.1 EMBL· GenBank· DDBJ | mRNA | ||
BC003149 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
BC071926 EMBL· GenBank· DDBJ | AAH71926.1 EMBL· GenBank· DDBJ | mRNA |