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P62847 · RS24_HUMAN

  • Protein
    Small ribosomal subunit protein eS24
  • Gene
    RPS24
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Component of the small ribosomal subunit (PubMed:23636399).
The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399).
Required for processing of pre-rRNA and maturation of 40S ribosomal subunits (PubMed:18230666).
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentcytosolic ribosome
Cellular Componentcytosolic small ribosomal subunit
Cellular Componentendoplasmic reticulum
Cellular Componentmembrane
Cellular Componentnucleolus
Cellular Componentnucleoplasm
Cellular Componentnucleus
Cellular Componentsmall ribosomal subunit
Cellular Componentsmall-subunit processome
Molecular FunctionRNA binding
Molecular Functionstructural constituent of ribosome
Molecular Functiontranslation initiation factor binding
Biological Processcytoplasmic translation
Biological Processerythrocyte homeostasis
Biological Processribosomal small subunit biogenesis
Biological ProcessrRNA processing
Biological Processtranslation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Small ribosomal subunit protein eS24
  • Alternative names
    • 40S ribosomal protein S24

Gene names

    • Name
      RPS24

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P62847
  • Secondary accessions
    • E7EPK6
    • P16632
    • Q5T0P7
    • Q5T0P8
    • Q7Z3D1

Proteomes

Organism-specific databases

Disease & Variants

Involvement in disease

Diamond-Blackfan anemia 3 (DBA3)

  • Note
    • The disease is caused by variants affecting the gene represented in this entry
  • Description
    A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of developing leukemia. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
  • See also
    MIM:610629

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 124 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue, chain, cross-link, modified residue (large scale data).

Type
IDPosition(s)Source
Description
Modified residue1UniProtN-acetylmethionine
ChainPRO_00001376231-133UniProtSmall ribosomal subunit protein eS24
Modified residue9UniProtPhosphothreonine
Cross-link37UniProtGlycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Modified residue (large scale data)76PRIDEPhosphotyrosine
Modified residue (large scale data)81PRIDEPhosphotyrosine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Mature tissues, such as adult brain, skeletal muscle, heart, and kidney, express low levels, whereas tissues and organs with significant populations of proliferating cells, such as fetal brain, placenta, bone marrow, and various glandular organs, contain significantly higher levels.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Component of the small ribosomal subunit (PubMed:23636399).
Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (PubMed:34516797).

Complex viewer

View interactors in UniProtKB
View CPX-5223 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region92-133Disordered
Compositional bias94-118Basic residues

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (4)
  • Sequence status
    Complete

This entry describes 4 isoforms produced by Alternative splicing.

P62847-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    133
  • Mass (Da)
    15,423
  • Last updated
    2004-08-16 v1
  • MD5 Checksum
    BC633404322CF5D5D93506A98D33F4BE
MNDTVTIRTRKFMTNRLLQRKQMVIDVLHPGKATVPKTEIREKLAKMYKTTPDVIFVFGFRTHFGGGKTTGFGMIYDSLDYAKKNEPKHRLARHGLYEKKKTSRKQRKERKNRMKKVRGTAKANVGAGKKPKE

P62847-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

P62847-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

P62847-4

  • Name
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 131-133: PKE → MRELGLGVQALGRISQEERCTDVKNSKARESRGVVWQVEVPGPWSVWTCGRLRRGCGKYLQVAVTWRKTENREQCCQACLLERALVRNGAFMSPASPAPAGSPHPVDGDLVLHLPEALSATLTLSPHIQAINKSFGPFFEIHQESSCFSPPSCLSGLGH

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2R8Y8A0A0A2R8Y8A0_HUMANRPS2490
A0A2R8Y849A0A2R8Y849_HUMANRPS24131
E7ETK0E7ETK0_HUMANRPS24131
A0A2R8YD14A0A2R8YD14_HUMANRPS24165

Features

Showing features for compositional bias, alternative sequence.

Type
IDPosition(s)Description
Compositional bias94-118Basic residues
Alternative sequenceVSP_005724131-133in isoform 2
Alternative sequenceVSP_039113131-133in isoform 3
Alternative sequenceVSP_045672131-133in isoform 4

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M31520
EMBL· GenBank· DDBJ
AAA36588.1
EMBL· GenBank· DDBJ
mRNA
U12202
EMBL· GenBank· DDBJ
AAB08007.1
EMBL· GenBank· DDBJ
Genomic DNA
U12202
EMBL· GenBank· DDBJ
AAB08006.1
EMBL· GenBank· DDBJ
Genomic DNA
BX336465
EMBL· GenBank· DDBJ
-mRNA No translation available.
AK311776
EMBL· GenBank· DDBJ
BAG34719.1
EMBL· GenBank· DDBJ
mRNA
AK311910
EMBL· GenBank· DDBJ
BAG34851.1
EMBL· GenBank· DDBJ
mRNA
BX537975
EMBL· GenBank· DDBJ
CAD97939.1
EMBL· GenBank· DDBJ
mRNA
AL512628
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471083
EMBL· GenBank· DDBJ
EAW54623.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471083
EMBL· GenBank· DDBJ
EAW54625.1
EMBL· GenBank· DDBJ
Genomic DNA
BC000523
EMBL· GenBank· DDBJ
AAH00523.1
EMBL· GenBank· DDBJ
mRNA
BC003149
EMBL· GenBank· DDBJ
-mRNA No translation available.
BC071926
EMBL· GenBank· DDBJ
AAH71926.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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