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P62277 · RS13_HUMAN

  • Protein
    Small ribosomal subunit protein uS15
  • Gene
    RPS13
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentcytosolic ribosome
Cellular Componentcytosolic small ribosomal subunit
Cellular Componentextracellular exosome
Cellular Componentfocal adhesion
Cellular Componentmembrane
Cellular Componentnucleolus
Cellular Componentnucleoplasm
Cellular Componentnucleus
Cellular Componentpostsynaptic density
Cellular Componentribosome
Cellular Componentsmall-subunit processome
Molecular FunctionmRNA 5'-UTR binding
Molecular FunctionmRNA binding
Molecular FunctionRNA binding
Molecular Functionsmall ribosomal subunit rRNA binding
Molecular Functionstructural constituent of ribosome
Biological Processcytoplasmic translation
Biological Processnegative regulation of RNA splicing
Biological Processribosomal small subunit biogenesis
Biological Processtranslation

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Small ribosomal subunit protein uS15
  • Alternative names
    • 40S ribosomal protein S13

Gene names

    • Name
      RPS13

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P62277
  • Secondary accessions
    • B2R549
    • P19116
    • Q02546
    • Q29200
    • Q498Y0

Proteomes

Organism-specific databases

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 94 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for initiator methionine, chain, modified residue (large scale data), modified residue, cross-link.

Type
IDPosition(s)Source
Description
Initiator methionine1UniProtRemoved
ChainPRO_00001156612-151UniProtSmall ribosomal subunit protein uS15
Modified residue (large scale data)12PRIDEPhosphoserine
Modified residue (large scale data)14PRIDEPhosphoserine
Modified residue27UniProtN6-acetyllysine; alternate
Modified residue27UniProtN6-succinyllysine; alternate
Cross-link27UniProtGlycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Modified residue30UniProtPhosphoserine
Modified residue (large scale data)30PRIDEPhosphoserine
Modified residue34UniProtN6-succinyllysine
Modified residue38UniProtPhosphotyrosine
Modified residue (large scale data)38PRIDEPhosphotyrosine
Cross-link43UniProtGlycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)

Post-translational modification

Ubiquitinated at Lys-27 by RNF14 and RNF25 in response to ribosome collisions (ribosome stalling).

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

Component of the small ribosomal subunit. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (PubMed:34516797).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntAct
BINARY P62277LRRK2 Q5S0073EBI-351850, EBI-5323863
BINARY P62277MAP3K14 Q995583EBI-351850, EBI-358011
BINARY P62277PDCD4 Q53EL62EBI-351850, EBI-935824

Complex viewer

View interactors in UniProtKB
View CPX-5223 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    151
  • Mass (Da)
    17,222
  • Last updated
    2007-01-23 v2
  • MD5 Checksum
    D86AC6C70EF9F6971BD3A95D11CA065B
MGRMHAPGKGLSQSALPYRRSVPTWLKLTSDDVKEQIYKLAKKGLTPSQIGVILRDSHGVAQVRFVTGNKILRILKSKGLAPDLPEDLYHLIKKAVAVRKHLERNRKDKDAKFRLILIESRIHRLARYYKTKRVLPPNWKYESSTASALVA

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
J3KMX5J3KMX5_HUMANRPS13148
E9PS50E9PS50_HUMANRPS13116

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict82in Ref. 8; AAC15854

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L01124
EMBL· GenBank· DDBJ
AAA60283.1
EMBL· GenBank· DDBJ
mRNA
X79239
EMBL· GenBank· DDBJ
CAA55821.1
EMBL· GenBank· DDBJ
mRNA
D88010
EMBL· GenBank· DDBJ
BAA13528.1
EMBL· GenBank· DDBJ
Genomic DNA
AK312060
EMBL· GenBank· DDBJ
BAG34996.1
EMBL· GenBank· DDBJ
mRNA
CH471064
EMBL· GenBank· DDBJ
EAW68448.1
EMBL· GenBank· DDBJ
Genomic DNA
BC000475
EMBL· GenBank· DDBJ
AAH00475.1
EMBL· GenBank· DDBJ
mRNA
BC006772
EMBL· GenBank· DDBJ
AAH06772.1
EMBL· GenBank· DDBJ
mRNA
BC029732
EMBL· GenBank· DDBJ
AAH29732.1
EMBL· GenBank· DDBJ
mRNA
BC066322
EMBL· GenBank· DDBJ
AAH66322.1
EMBL· GenBank· DDBJ
mRNA
BC100032
EMBL· GenBank· DDBJ
AAI00033.1
EMBL· GenBank· DDBJ
mRNA
L05090
EMBL· GenBank· DDBJ
AAC15854.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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