P62244 · RS15A_HUMAN
- ProteinSmall ribosomal subunit protein uS8
- GeneRPS15A
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids130 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Component of the small ribosomal subunit (PubMed:23636399).
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797).
Required for proper erythropoiesis (PubMed:27909223).
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797).
Required for proper erythropoiesis (PubMed:27909223).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | cytosolic ribosome | |
Cellular Component | cytosolic small ribosomal subunit | |
Cellular Component | extracellular exosome | |
Cellular Component | membrane | |
Cellular Component | nucleolus | |
Cellular Component | nucleoplasm | |
Cellular Component | small-subunit processome | |
Cellular Component | synapse | |
Molecular Function | RNA binding | |
Molecular Function | structural constituent of ribosome | |
Biological Process | cytoplasmic translation | |
Biological Process | positive regulation of cell cycle | |
Biological Process | positive regulation of cell population proliferation | |
Biological Process | response to virus | |
Biological Process | ribosomal small subunit biogenesis | |
Biological Process | translation |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSmall ribosomal subunit protein uS8
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP62244
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Involvement in disease
Diamond-Blackfan anemia 20 (DBA20)
- Note
- DescriptionA form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. DBA20 inheritance is autosomal dominant.
- See alsoMIM:618313
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 73 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for initiator methionine, chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Initiator methionine | 1 | Removed | |||
Chain | PRO_0000126602 | 2-130 | Small ribosomal subunit protein uS8 | ||
Modified residue | 88 | N6-succinyllysine | |||
Proteomic databases
PTM databases
Expression
Interaction
Subunit
Component of the 40S ribosomal subunit. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (PubMed:34516797).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | IntAct | |
---|---|---|---|---|---|
BINARY | P62244 | FGFR3 P22607 | 3 | EBI-347895, EBI-348399 | |
BINARY | P62244 | GRN P28799 | 3 | EBI-347895, EBI-747754 | |
BINARY | P62244 | GSN P06396 | 3 | EBI-347895, EBI-351506 | |
BINARY | P62244 | HSPB1 P04792 | 3 | EBI-347895, EBI-352682 | |
BINARY | P62244 | HTT P42858 | 3 | EBI-347895, EBI-466029 | |
BINARY | P62244 | KIF1B O60333-2 | 3 | EBI-347895, EBI-10975473 | |
BINARY | P62244 | PMP22 A0A6Q8PF08 | 3 | EBI-347895, EBI-50433196 | |
BINARY | P62244 | RNF11 Q9Y3C5 | 3 | EBI-347895, EBI-396669 | |
BINARY | P62244 | WFS1 O76024 | 3 | EBI-347895, EBI-720609 |
Complex viewer
Protein-protein interaction databases
Miscellaneous
Structure
Sequence
- Sequence statusComplete
- Length130
- Mass (Da)14,840
- Last updated2007-01-23 v2
- MD5 Checksum3A47751F718F7A268F1B8C8242330A70
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Sequence caution
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 3 | in Ref. 6; AA sequence | |||
Sequence conflict | 40 | in Ref. 2; CAA59127 | |||
Sequence conflict | 79 | in Ref. 5; AAH01697 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X62691 EMBL· GenBank· DDBJ | CAA44568.1 EMBL· GenBank· DDBJ | mRNA | Frameshift | |
X84407 EMBL· GenBank· DDBJ | CAA59127.1 EMBL· GenBank· DDBJ | mRNA | ||
AY208299 EMBL· GenBank· DDBJ | AAO48936.1 EMBL· GenBank· DDBJ | mRNA | ||
AB062400 EMBL· GenBank· DDBJ | BAB93487.1 EMBL· GenBank· DDBJ | mRNA | ||
BC001697 EMBL· GenBank· DDBJ | AAH01697.1 EMBL· GenBank· DDBJ | mRNA | ||
BC030569 EMBL· GenBank· DDBJ | AAH30569.1 EMBL· GenBank· DDBJ | mRNA | ||
BC046113 EMBL· GenBank· DDBJ | AAH46113.1 EMBL· GenBank· DDBJ | mRNA | ||
BC105273 EMBL· GenBank· DDBJ | AAI05274.1 EMBL· GenBank· DDBJ | mRNA | ||
BC105292 EMBL· GenBank· DDBJ | AAI05293.1 EMBL· GenBank· DDBJ | mRNA | ||
AB007154 EMBL· GenBank· DDBJ | BAA28592.1 EMBL· GenBank· DDBJ | Genomic DNA |