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P62244 · RS15A_HUMAN

  • Protein
    Small ribosomal subunit protein uS8
  • Gene
    RPS15A
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Component of the small ribosomal subunit (PubMed:23636399).
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797).
Required for proper erythropoiesis (PubMed:27909223).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentcytosolic ribosome
Cellular Componentcytosolic small ribosomal subunit
Cellular Componentextracellular exosome
Cellular Componentmembrane
Cellular Componentnucleolus
Cellular Componentnucleoplasm
Cellular Componentsmall-subunit processome
Cellular Componentsynapse
Molecular FunctionRNA binding
Molecular Functionstructural constituent of ribosome
Biological Processcytoplasmic translation
Biological Processpositive regulation of cell cycle
Biological Processpositive regulation of cell population proliferation
Biological Processresponse to virus
Biological Processribosomal small subunit biogenesis
Biological Processtranslation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Small ribosomal subunit protein uS8
  • Alternative names
    • 40S ribosomal protein S15a

Gene names

    • Name
      RPS15A
    • ORF names
      OK/SW-cl.82

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P62244
  • Secondary accessions
    • P39027
    • P39031
    • Q3MHD9
    • Q8C023
    • Q9BV24

Proteomes

Organism-specific databases

Disease & Variants

Involvement in disease

Diamond-Blackfan anemia 20 (DBA20)

  • Note
    • The disease may be caused by variants affecting the gene represented in this entry
  • Description
    A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. DBA20 inheritance is autosomal dominant.
  • See also
    MIM:618313

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 73 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for initiator methionine, chain, modified residue.

Type
IDPosition(s)Description
Initiator methionine1Removed
ChainPRO_00001266022-130Small ribosomal subunit protein uS8
Modified residue88N6-succinyllysine

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

Component of the 40S ribosomal subunit. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (PubMed:34516797).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntAct
BINARY P62244FGFR3 P226073EBI-347895, EBI-348399
BINARY P62244GRN P287993EBI-347895, EBI-747754
BINARY P62244GSN P063963EBI-347895, EBI-351506
BINARY P62244HSPB1 P047923EBI-347895, EBI-352682
BINARY P62244HTT P428583EBI-347895, EBI-466029
BINARY P62244KIF1B O60333-23EBI-347895, EBI-10975473
BINARY P62244PMP22 A0A6Q8PF083EBI-347895, EBI-50433196
BINARY P62244RNF11 Q9Y3C53EBI-347895, EBI-396669
BINARY P62244WFS1 O760243EBI-347895, EBI-720609

Complex viewer

View interactors in UniProtKB
View CPX-5223 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    130
  • Mass (Da)
    14,840
  • Last updated
    2007-01-23 v2
  • MD5 Checksum
    3A47751F718F7A268F1B8C8242330A70
MVRMNVLADALKSINNAEKRGKRQVLIRPCSKVIVRFLTVMMKHGYIGEFEIIDDHRAGKIVVNLTGRLNKCGVISPRFDVQLKDLEKWQNNLLPSRQFGFIVLTTSAGIMDHEEARRKHTGGKILGFFF

Computationally mapped potential isoform sequences

There are 6 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
H3BV27H3BV27_HUMANRPS15A49
H3BVC7H3BVC7_HUMANRPS15A58
H3BT37H3BT37_HUMANRPS15A50
I3L3P7I3L3P7_HUMANRPS15A100
I3L303I3L303_HUMANRPS15A52
I3L246I3L246_HUMANRPS15A111

Sequence caution

The sequence CAA44568.1 differs from that shown. Reason: Frameshift

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict3in Ref. 6; AA sequence
Sequence conflict40in Ref. 2; CAA59127
Sequence conflict79in Ref. 5; AAH01697

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X62691
EMBL· GenBank· DDBJ
CAA44568.1
EMBL· GenBank· DDBJ
mRNA Frameshift
X84407
EMBL· GenBank· DDBJ
CAA59127.1
EMBL· GenBank· DDBJ
mRNA
AY208299
EMBL· GenBank· DDBJ
AAO48936.1
EMBL· GenBank· DDBJ
mRNA
AB062400
EMBL· GenBank· DDBJ
BAB93487.1
EMBL· GenBank· DDBJ
mRNA
BC001697
EMBL· GenBank· DDBJ
AAH01697.1
EMBL· GenBank· DDBJ
mRNA
BC030569
EMBL· GenBank· DDBJ
AAH30569.1
EMBL· GenBank· DDBJ
mRNA
BC046113
EMBL· GenBank· DDBJ
AAH46113.1
EMBL· GenBank· DDBJ
mRNA
BC105273
EMBL· GenBank· DDBJ
AAI05274.1
EMBL· GenBank· DDBJ
mRNA
BC105292
EMBL· GenBank· DDBJ
AAI05293.1
EMBL· GenBank· DDBJ
mRNA
AB007154
EMBL· GenBank· DDBJ
BAA28592.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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