P50914 · RL14_HUMAN
- ProteinLarge ribosomal subunit protein eL14
- GeneRPL14
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids215 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547).
The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547).
The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | cytosolic large ribosomal subunit | |
Cellular Component | cytosolic ribosome | |
Cellular Component | extracellular exosome | |
Cellular Component | membrane | |
Cellular Component | postsynaptic density | |
Molecular Function | cadherin binding | |
Molecular Function | RNA binding | |
Molecular Function | structural constituent of ribosome | |
Biological Process | cytoplasmic translation | |
Biological Process | ribosomal large subunit biogenesis | |
Biological Process | rRNA processing | |
Biological Process | translation |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLarge ribosomal subunit protein eL14
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP50914
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Natural variant | VAR_013633 | 138 | in dbSNP:rs929099541 | ||
Natural variant | VAR_047109 | 158-159 | |||
Natural variant | VAR_013634 | 159 | |||
Natural variant | VAR_014070 | 159 | |||
Natural variant | VAR_013635 | 159 | |||
Natural variant | VAR_013636 | 159 | |||
Natural variant | VAR_006923 | 159 | |||
Natural variant | VAR_013637 | 159 | |||
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 261 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for initiator methionine, chain, modified residue, cross-link, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | ||
---|---|---|---|---|---|---|
Initiator methionine | 1 | UniProt | Removed | |||
Chain | PRO_0000132031 | 2-215 | UniProt | Large ribosomal subunit protein eL14 | ||
Modified residue | 79 | UniProt | N6-acetyllysine | |||
Modified residue | 85 | UniProt | N6-acetyllysine; alternate | |||
Modified residue | 85 | UniProt | N6-succinyllysine; alternate | |||
Cross-link | 124 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | |||
Modified residue | 139 | UniProt | Phosphoserine | |||
Modified residue (large scale data) | 139 | PRIDE | Phosphoserine | |||
Modified residue | 204 | UniProt | N6-succinyllysine | |||
Modified residue (large scale data) | 211 | PRIDE | Phosphoserine | |||
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Subunit
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | IntAct | |
---|---|---|---|---|---|
BINARY | P50914 | H1-4 P10412 | 2 | EBI-356746, EBI-358163 | |
BINARY | P50914 | LRRK2 Q5S007 | 2 | EBI-356746, EBI-5323863 | |
BINARY | P50914 | PHLDA1 Q8WV24 | 2 | EBI-356746, EBI-738731 | |
BINARY | P50914 | RPL4 P36578 | 4 | EBI-356746, EBI-348313 |
Complex viewer
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, repeat.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 161-215 | Disordered | |||
Repeat | 171-175 | 1-1 | |||
Region | 171-190 | 4 X 5 AA tandem repeats of Q-K-A-[PAS]-X | |||
Repeat | 176-180 | 1-2 | |||
Repeat | 181-185 | 1-3 | |||
Repeat | 186-190 | 1-4 | |||
Repeat | 193-195 | 2-1 | |||
Region | 193-198 | 2 X 3 AA tandem repeats of K-[GA]-Q | |||
Repeat | 196-198 | 2-2 | |||
Sequence similarities
Belongs to the eukaryotic ribosomal protein eL14 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length215
- Mass (Da)23,432
- Last updated2008-11-04 v4
- MD5 Checksum9BAD67F1538FD42DE5688C52DD1F6F90
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 65 | in Ref. 2; BAA13443 | |||
Polymorphism
The poly-Ala stretch is highly polymorphic.
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U16738 EMBL· GenBank· DDBJ | AAC16021.1 EMBL· GenBank· DDBJ | mRNA | ||
D87735 EMBL· GenBank· DDBJ | BAA13443.1 EMBL· GenBank· DDBJ | mRNA | ||
AB061822 EMBL· GenBank· DDBJ | BAB79460.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ118667 EMBL· GenBank· DDBJ | AAZ38460.1 EMBL· GenBank· DDBJ | mRNA | ||
AK223111 EMBL· GenBank· DDBJ | BAD96831.1 EMBL· GenBank· DDBJ | mRNA | ||
AC104186 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC000606 EMBL· GenBank· DDBJ | AAH00606.1 EMBL· GenBank· DDBJ | mRNA | ||
BC005134 EMBL· GenBank· DDBJ | AAH05134.1 EMBL· GenBank· DDBJ | mRNA | ||
BC009294 EMBL· GenBank· DDBJ | AAH09294.1 EMBL· GenBank· DDBJ | mRNA | ||
BC019651 EMBL· GenBank· DDBJ | AAH19651.1 EMBL· GenBank· DDBJ | mRNA | ||
BC022805 EMBL· GenBank· DDBJ | AAH22805.1 EMBL· GenBank· DDBJ | mRNA | ||
BC029036 EMBL· GenBank· DDBJ | AAH29036.1 EMBL· GenBank· DDBJ | mRNA | ||
AB046407 EMBL· GenBank· DDBJ | BAB21253.1 EMBL· GenBank· DDBJ | Genomic DNA |