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Entry version 182 (07 Apr 2021)
Sequence version 1 (01 Oct 1996)
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Protein

Serine/threonine-protein kinase plo1

Gene

plo1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required to form a bipolar spindle, the actin ring and septum. Functions upstream of the whole septum formation pathway, including actin ring formation (regulated by late septation genes) and septal material deposition (regulated by early septation genes). Behaves as a 'septum-promoting factor', and could also be involved in inducing other late events of cell division (PubMed:12615979, PubMed:12815070, PubMed:7744248). Together with moa1, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (PubMed:25533956).4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei69ATPCurated1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei163Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi47 – 55ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, Cell division, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.11.21, 5613

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SPO-156711, Polo-like kinase mediated events
R-SPO-162658, Golgi Cisternae Pericentriolar Stack Reorganization
R-SPO-2500257, Resolution of Sister Chromatid Cohesion
R-SPO-2565942, Regulation of PLK1 Activity at G2/M Transition
R-SPO-6804115, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
R-SPO-68884, Mitotic Telophase/Cytokinesis
R-SPO-9648025, EML4 and NUDC in mitotic spindle formation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase plo1 (EC:2.7.11.21)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:plo1
ORF Names:SPAC23C11.16
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Schizosaccharomyces pombe database

More...
PomBasei
SPAC23C11.16, plo1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPAC23C11.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi69K → Q: Loss of function. 1 Publication1
Mutagenesisi69K → R: Loss of function. 1 Publication1
Mutagenesisi124S → D: Enhances kinase activity; when associated with D-197. 1 Publication1
Mutagenesisi139E → K in ts allele plo1.ts2. Impairs kinase activity at both 25 and 36 degrees Celsius and impairs association with the spindle pole body and bipolar spindle formation. 1 Publication1
Mutagenesisi181D → R: Loss of function. 1 Publication1
Mutagenesisi193E → G: Loss of function. 1 Publication1
Mutagenesisi197T → D: Enhances kinase activity; when associated with D-124. 2 Publications1
Mutagenesisi197T → V: Loss of function. 2 Publications1
Mutagenesisi251K → E: Loss of function and impairs interaction with spac6b12.08. 1 Publication1
Mutagenesisi252I → T: Loss of function and impairs interaction with spac6b12.08. 1 Publication1
Mutagenesisi256S → P: Loss of function and impairs interaction with spac6b12.08. 1 Publication1
Mutagenesisi493F → L: Loss of function and impairs interaction with cut23 and spac6b12.08. 1 Publication1
Mutagenesisi497W → F: Loss of function. 1 Publication1
Mutagenesisi498V → A: Loss of function and impairs interaction with dmf1, spac1006.03c and spac6b12.08. 1 Publication1
Mutagenesisi505G → A: Loss of function. 1 Publication1
Mutagenesisi508 – 510YQL → AAA: Loss of function. 1 Publication3
Mutagenesisi519 – 520FN → AA: Loss of function. 1 Publication2
Mutagenesisi533V → A: Loss of function and impairs interaction with cut23, dmf1 and spac6b12.08. 1 Publication1
Mutagenesisi565L → F: Loss of function and impairs interaction with cut23. 1 Publication1
Mutagenesisi572 – 573YM → AA: Loss of function. 1 Publication2
Mutagenesisi605R → P: Loss of function and impairs interaction with cut23. 1 Publication1
Mutagenesisi625 – 627DHR → AAA: Loss of function. 1 Publication3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000865721 – 683Serine/threonine-protein kinase plo1Add BLAST683

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei442Phosphoserine1 Publication1
Modified residuei585Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P50528

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P50528

PRoteomics IDEntifications database

More...
PRIDEi
P50528

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P50528

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with abp2, cut12, cut23, dmf1, sck1, sid4, spac1006.03c, spac6b12.08, spac26h5.05 and sum1.

Interacts with moa1 (PubMed:25533956).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
278444, 56 interactors

Database of interacting proteins

More...
DIPi
DIP-35381N

Protein interaction database and analysis system

More...
IntActi
P50528, 16 interactors

Molecular INTeraction database

More...
MINTi
P50528

STRING: functional protein association networks

More...
STRINGi
4896.SPAC23C11.16.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P50528

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 296Protein kinasePROSITE-ProRule annotationAdd BLAST256
Domaini500 – 567POLO box 1PROSITE-ProRule annotationAdd BLAST68
Domaini604 – 670POLO box 2PROSITE-ProRule annotationAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni317 – 683Localization to the spindle poly bodyAdd BLAST367
Regioni322 – 683Interaction with cut12Add BLAST362

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0575, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000288_46_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P50528

Identification of Orthologs from Complete Genome Data

More...
OMAi
FEVDTWS

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P50528

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13118, POLO_box_1, 1 hit
cd13117, POLO_box_2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1120.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR033701, POLO_box_1
IPR033695, POLO_box_2
IPR000959, POLO_box_dom
IPR036947, POLO_box_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069, Pkinase, 1 hit
PF00659, POLO_box, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50078, POLO_BOX, 2 hits
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P50528-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASVAIKEPK TAITPKKKSK ASRLCFTPPT NLHNNKKNIF YTRYDCIGEG
60 70 80 90 100
GFARCFRVKD NYGNIYAAKV IAKRSLQNDK TKLKLFGEIK VHQSMSHPNI
110 120 130 140 150
VGFIDCFEDS TNIYLILELC EHKSLMELLR KRKQLTEPEV RYLMMQILGA
160 170 180 190 200
LKYMHKKRVI HRDLKLGNIM LDESNNVKIG DFGLAALLMD DEERKMTICG
210 220 230 240 250
TPNYIAPEIL FNSKEGHSFE VDLWSAGVVM YALLIGKPPF QDKEVKTIYR
260 270 280 290 300
KIKANSYSFP SNVDISAEAK DLISSLLTHD PSIRPSIDDI VDHEFFHTGY
310 320 330 340 350
MASTLPDEIL HSMPIWPSSQ SKSSFQRNLD FVASASGVGF GNSAGVEKNK
360 370 380 390 400
PYALRTDEVD NDRILPSVLS PRDRVNPVMK IGPETKPVPS KLSTALHAAR
410 420 430 440 450
KSTDGSLGSR VKVLREESQS FVPTKSAVTE QVEPIQLIRS LSANTVSRLS
460 470 480 490 500
KVGNMKSDIW ISVKKTALKI GMALEAHTHA LTSEDADSEP VLFITKWVDY
510 520 530 540 550
SNKYGLGYQL SDESVGVHFN DDTSLLFSAD EEVVEYALHP KDTEIKPYIY
560 570 580 590 600
PASKVPESIR SKLQLLKHFK SYMGQNLSKA VQDESFEKPK NSTSNTMLFM
610 620 630 640 650
QHYLRTRQAI MFRLSNGIFQ FNFLDHRKVV ISSTARKIIV LDKERERVEL
660 670 680
PLQEASAFSE DLRSRLKYIR ETLESWASKM EVS
Length:683
Mass (Da):77,302
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF11CD0EF9B913917
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X85758 Genomic DNA Translation: CAA59766.1
CU329670 Genomic DNA Translation: CAB11167.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T38254

NCBI Reference Sequences

More...
RefSeqi
NP_593647.1, NM_001019078.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPAC23C11.16.1; SPAC23C11.16.1:pep; SPAC23C11.16

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2541957

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPAC23C11.16

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85758 Genomic DNA Translation: CAA59766.1
CU329670 Genomic DNA Translation: CAB11167.1
PIRiT38254
RefSeqiNP_593647.1, NM_001019078.2

3D structure databases

SMRiP50528
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi278444, 56 interactors
DIPiDIP-35381N
IntActiP50528, 16 interactors
MINTiP50528
STRINGi4896.SPAC23C11.16.1

PTM databases

iPTMnetiP50528

Proteomic databases

MaxQBiP50528
PaxDbiP50528
PRIDEiP50528

Genome annotation databases

EnsemblFungiiSPAC23C11.16.1; SPAC23C11.16.1:pep; SPAC23C11.16
GeneIDi2541957
KEGGispo:SPAC23C11.16

Organism-specific databases

PomBaseiSPAC23C11.16, plo1
VEuPathDBiFungiDB:SPAC23C11.16

Phylogenomic databases

eggNOGiKOG0575, Eukaryota
HOGENOMiCLU_000288_46_2_1
InParanoidiP50528
OMAiFEVDTWS
PhylomeDBiP50528

Enzyme and pathway databases

BRENDAi2.7.11.21, 5613
ReactomeiR-SPO-156711, Polo-like kinase mediated events
R-SPO-162658, Golgi Cisternae Pericentriolar Stack Reorganization
R-SPO-2500257, Resolution of Sister Chromatid Cohesion
R-SPO-2565942, Regulation of PLK1 Activity at G2/M Transition
R-SPO-6804115, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
R-SPO-68884, Mitotic Telophase/Cytokinesis
R-SPO-9648025, EML4 and NUDC in mitotic spindle formation

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P50528

Family and domain databases

CDDicd13118, POLO_box_1, 1 hit
cd13117, POLO_box_2, 1 hit
Gene3Di3.30.1120.30, 2 hits
InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR033701, POLO_box_1
IPR033695, POLO_box_2
IPR000959, POLO_box_dom
IPR036947, POLO_box_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069, Pkinase, 1 hit
PF00659, POLO_box, 2 hits
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50078, POLO_BOX, 2 hits
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLO1_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P50528
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 7, 2021
This is version 182 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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