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P46782 · RS5_HUMAN

  • Protein
    Small ribosomal subunit protein uS7
  • Gene
    RPS5
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Component of the small ribosomal subunit (PubMed:23636399).
The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399).
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentcytosolic ribosome
Cellular Componentcytosolic small ribosomal subunit
Cellular Componentextracellular exosome
Cellular Componentfocal adhesion
Cellular Componentmembrane
Cellular Componentnucleolus
Cellular Componentnucleoplasm
Cellular Componentribonucleoprotein complex
Cellular Componentribosome
Cellular Componentsmall-subunit processome
Cellular Componentsynapse
Molecular FunctionmRNA binding
Molecular FunctionRNA binding
Molecular FunctionrRNA binding
Molecular Functionstructural constituent of ribosome
Biological Processcytoplasmic translation
Biological Processregulation of translational fidelity
Biological Processribosomal small subunit assembly
Biological Processribosomal small subunit biogenesis
Biological Processtranslation
Biological Processtranslational initiation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Gene names

    • Name
      RPS5

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P46782
  • Secondary accessions
    • B2R4T2
    • Q96BN0

Proteomes

Organism-specific databases

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 159 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain, modified residue (large scale data), cross-link.

Type
IDPosition(s)Source
Description
Initiator methionine1UniProtRemoved; alternate
Modified residue1UniProtN-acetylmethionine; in 40S ribosomal protein S5; alternate
ChainPRO_00003703691-204UniProtSmall ribosomal subunit protein uS7
Modified residue2UniProtN-acetylthreonine; in 40S ribosomal protein S5, N-terminally processed
Modified residue (large scale data)2PRIDEPhosphothreonine
ChainPRO_00001245262-204UniProtSmall ribosomal subunit protein uS7, N-terminally processed
Modified residue14UniProtPhosphothreonine
Modified residue (large scale data)14PRIDEPhosphothreonine
Modified residue47UniProtN6-acetyllysine; alternate
Cross-link47UniProtGlycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate
Modified residue (large scale data)52PRIDEPhosphoserine
Modified residue142UniProtPhosphoserine
Modified residue (large scale data)142PRIDEPhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

Component of the small ribosomal subunit. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (PubMed:34516797).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntAct
BINARY P46782ATXN1 P542533EBI-350569, EBI-930964
BINARY P46782HTT P428583EBI-350569, EBI-466029
BINARY P46782JPH3 Q8WXH23EBI-350569, EBI-1055254

Complex viewer

View interactors in UniProtKB
View CPX-5223 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    204
  • Mass (Da)
    22,876
  • Last updated
    2007-01-23 v4
  • MD5 Checksum
    0F8D5ECACFB3513A9C4F88BFD9C966F8
MTEWETAAPAVAETPDIKLFGKWSTDDVQINDISLQDYIAVKEKYAKYLPHSAGRYAAKRFRKAQCPIVERLTNSMMMHGRNNGKKLMTVRIVKHAFEIIHLLTGENPLQVLVNAIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECLADELINAAKGSSNSYAIKKKDELERVAKSNR

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
M0R0R2M0R0R2_HUMANRPS5225
M0R0F0M0R0F0_HUMANRPS5200
M0QZN2M0QZN2_HUMANRPS5134

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict59-60in Ref. 1; AAA85658

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U14970
EMBL· GenBank· DDBJ
AAA85658.1
EMBL· GenBank· DDBJ
mRNA
AB061853
EMBL· GenBank· DDBJ
BAB79493.1
EMBL· GenBank· DDBJ
Genomic DNA
AK311938
EMBL· GenBank· DDBJ
BAG34879.1
EMBL· GenBank· DDBJ
mRNA
CH471135
EMBL· GenBank· DDBJ
EAW72581.1
EMBL· GenBank· DDBJ
Genomic DNA
BC015405
EMBL· GenBank· DDBJ
AAH15405.1
EMBL· GenBank· DDBJ
mRNA
BC018151
EMBL· GenBank· DDBJ
AAH18151.1
EMBL· GenBank· DDBJ
mRNA
AB007149
EMBL· GenBank· DDBJ
BAA25815.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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