P28241 · IDH2_YEAST

Function

function

Performs an essential role in the oxidative function of the citric acid cycle. Also binds RNA; specifically to the 5'-untranslated leaders of mitochondrial mRNAs.

Miscellaneous

Present with 43100 molecules/cell in log phase SD medium.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 Mg2+ or Mn2+ ion per subunit.

Activity regulation

Allosterically regulated by several compounds including AMP, NAD+, and citrate.

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site119substrate
Binding site129substrate
Binding site150substrate
Site157Critical for catalysis
Site204Critical for catalysis
Binding site237Mg2+ (UniProtKB | ChEBI)
Binding site237substrate
Binding site263Mg2+ (UniProtKB | ChEBI)
Binding site267Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentisocitrate dehydrogenase complex (NAD+)
Cellular Componentmitochondrial matrix
Cellular Componentmitochondrion
Molecular Functionisocitrate dehydrogenase (NAD+) activity
Molecular Functionmagnesium ion binding
Molecular FunctionNAD binding
Molecular FunctionRNA binding
Biological Processglutamate biosynthetic process
Biological Processisocitrate metabolic process
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial
  • EC number
  • Alternative names
    • Isocitric dehydrogenase
    • NAD(+)-specific ICDH

Gene names

    • Name
      IDH2
    • ORF names
      O3326, YOR3326W
    • Ordered locus names
      YOR136W

Organism names

Accessions

  • Primary accession
    P28241
  • Secondary accessions
    • D6W2J3

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for transit peptide, chain, modified residue.

TypeIDPosition(s)Description
Transit peptide1-15Mitochondrion
ChainPRO_000001443416-369Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial
Modified residue105Phosphothreonine
Modified residue153Phosphothreonine
Modified residue327Phosphothreonine
Modified residue349Phosphothreonine

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Octamer of two non-identical subunits IDH1 and IDH2.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P28241IDH1 P288347EBI-8883, EBI-8878
View interactors in UniProtKB
View CPX-558 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    369
  • Mass (Da)
    39,739
  • Last updated
    1992-12-01 v1
  • Checksum
    3A48C999776CE373
MLRNTFFRNTSRRFLATVKQPSIGRYTGKPNPSTGKYTVSFIEGDGIGPEISKSVKKIFSAANVPIEWESCDVSPIFVNGLTTIPDPAVQSITKNLVALKGPLATPIGKGHRSLNLTLRKTFGLFANVRPAKSIEGFKTTYENVDLVLIRENTEGEYSGIEHIVCPGVVQSIKLITRDASERVIRYAFEYARAIGRPRVIVVHKSTIQRLADGLFVNVAKELSKEYPDLTLETELIDNSVLKVVTNPSAYTDAVSVCPNLYGDILSDLNSGLSAGSLGLTPSANIGHKISIFEAVHGSAPDIAGQDKANPTALLLSSVMMLNHMGLTNHADQIQNAVLSTIASGPENRTGDLAGTATTSSFTEAVIKRL

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict25in Ref. 6; AA sequence

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M74131
EMBL· GenBank· DDBJ
AAA34702.1
EMBL· GenBank· DDBJ
Genomic DNA
X94335
EMBL· GenBank· DDBJ
CAA64054.1
EMBL· GenBank· DDBJ
Genomic DNA
Z75043
EMBL· GenBank· DDBJ
CAA99335.1
EMBL· GenBank· DDBJ
Genomic DNA
X90518
EMBL· GenBank· DDBJ
CAA62110.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006948
EMBL· GenBank· DDBJ
DAA10909.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp