P28002 · COMT1_MEDSA

Function

function

Catalyzes the conversion of caffeic acid to ferulic acid and of 5-hydroxyferulic acid to sinapic acid (Probable) (PubMed:1898010).
The resulting products may subsequently be converted to the corresponding alcohols that are incorporated into lignins (Probable) (PubMed:1898010).

Catalytic activity

Pathway

Aromatic compound metabolism; phenylpropanoid biosynthesis.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site131(E)-ferulate (UniProtKB | ChEBI)
Binding site208S-adenosyl-L-homocysteine (UniProtKB | ChEBI)
Binding site231S-adenosyl-L-homocysteine (UniProtKB | ChEBI)
Binding site251S-adenosyl-L-homocysteine (UniProtKB | ChEBI)
Binding site252S-adenosyl-L-homocysteine (UniProtKB | ChEBI)
Binding site264S-adenosyl-L-homocysteine (UniProtKB | ChEBI)
Binding site265S-adenosyl-L-homocysteine (UniProtKB | ChEBI)
Active site269Proton acceptor
Binding site270(E)-5-hydroxyferulate (UniProtKB | ChEBI)
Active site297
Active site329

GO annotations

AspectTerm
Molecular Functioncaffeate O-methyltransferase activity
Molecular Functionprotein dimerization activity
Molecular FunctionS-adenosylmethionine-dependent methyltransferase activity
Biological Processlignin biosynthetic process
Biological Processmethylation
Biological Processphenylpropanoid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Caffeic acid 3-O-methyltransferase
  • EC number
  • Short names
    CAOMT
    ; COMT
  • Alternative names
    • S-adenosysl-L-methionine:caffeic acid 3-O-methyltransferase

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Apollo
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Fabales > Fabaceae > Papilionoideae > 50 kb inversion clade > NPAAA clade > Hologalegina > IRL clade > Trifolieae > Medicago

Accessions

  • Primary accession
    P28002
  • Secondary accessions
    • D0VDZ3

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000632041-365Caffeic acid 3-O-methyltransferase

Expression

Tissue specificity

More abundant in roots and stems.

Induction

By infection, plant wounding, or elicitor treatment of cell cultures.

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    365
  • Mass (Da)
    39,946
  • Last updated
    1992-08-01 v1
  • MD5 Checksum
    DCB1AAF03F93D8D0B6D174AC70078416
MGSTGETQITPTHISDEEANLFAMQLASASVLPMILKSALELDLLEIIAKAGPGAQISPIEIASQLPTTNPDAPVMLDRMLRLLACYIILTCSVRTQQDGKVQRLYGLATVAKYLVKNEDGVSISALNLMNQDKVLMESWYHLKDAVLDGGIPFNKAYGMTAFEYHGTDPRFNKVFNKGMSDHSTITMKKILETYTGFEGLKSLVDVGGGTGAVINTIVSKYPTIKGINFDLPHVIEDAPSYPGVEHVGGDMFVSIPKADAVFMKWICHDWSDEHCLKFLKNCYEALPDNGKVIVAECILPVAPDSSLATKGVVHIDVIMLAHNPGGKERTQKEFEDLAKGAGFQGFKVHCNAFNTYIMEFLKKV

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict88in Ref. 2; ACY06328

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M63853
EMBL· GenBank· DDBJ
AAB46623.1
EMBL· GenBank· DDBJ
mRNA
GU066087
EMBL· GenBank· DDBJ
ACY06328.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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