Protein bride of sevenless

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• adenylate cyclase inhibiting G protein-coupled glutamate receptor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• receptor ligand activity Source: FlyBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Extracellular domain of the boss transmembrane ligand acts as an antagonist of the sev receptor."
    Hart A.C., Kramer H., Zipursky S.L.
    Nature 361:732-736(1993) [PubMed] [Europe PMC] [Abstract]
• sevenless binding Source: FlyBaseInferred from direct assayⁱ
  • "Extracellular domain of the boss transmembrane ligand acts as an antagonist of the sev receptor."
    Hart A.C., Kramer H., Zipursky S.L.
    Nature 361:732-736(1993) [PubMed] [Europe PMC] [Abstract]
  • "Oligomerization of the extracellular domain of Boss enhances its binding to the Sevenless receptor and its antagonistic effect on R7 induction."
    Sevrioukov E.A., Walenta J.H., Sunio A., Phistry M., Kramer H.
    J Cell Sci 111:737-747(1998) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• germ-line stem-cell niche homeostasis Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Boss/Sev signaling from germline to soma restricts germline-stem-cell-niche formation in the anterior region of Drosophila male gonads."
    Kitadate Y., Shigenobu S., Arita K., Kobayashi S.
    Dev Cell 13:151-159(2007) [PubMed] [Europe PMC] [Abstract]
• glucose homeostasis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "A Drosophila orphan G protein-coupled receptor BOSS functions as a glucose-responding receptor: loss of boss causes abnormal energy metabolism."
    Kohyama-Koganeya A., Kim Y.J., Miura M., Hirabayashi Y.
    Proc Natl Acad Sci U S A 105:15328-15333(2008) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled glutamate receptor signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• lipid homeostasis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "A Drosophila orphan G protein-coupled receptor BOSS functions as a glucose-responding receptor: loss of boss causes abnormal energy metabolism."
    Kohyama-Koganeya A., Kim Y.J., Miura M., Hirabayashi Y.
    Proc Natl Acad Sci U S A 105:15328-15333(2008) [PubMed] [Europe PMC] [Abstract]
• R7 cell fate commitment Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Induction in the developing compound eye of Drosophila: multiple mechanisms restrict R7 induction to a single retinal precursor cell."
    Van Vactor D.L. Jr., Cagan R.L., Kramer H., Zipursky S.L.
    Cell 67:1145-1155(1991) [PubMed] [Europe PMC] [Abstract]
  • "Cell-cell interaction in the Drosophila retina: the bride of sevenless gene is required in photoreceptor cell R8 for R7 cell development."
    Reinke R., Zipursky S.L.
    Cell 55:321-330(1988) [PubMed] [Europe PMC] [Abstract]
• R8 cell-mediated photoreceptor organization Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Cell-cell interaction in the Drosophila retina: the bride of sevenless gene is required in photoreceptor cell R8 for R7 cell development."
    Reinke R., Zipursky S.L.
    Cell 55:321-330(1988) [PubMed] [Europe PMC] [Abstract]
• regulation of synaptic transmission, glutamatergic Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• response to glucose Source: FlyBaseInferred from mutant phenotypeⁱ
  • "A Drosophila orphan G protein-coupled receptor BOSS functions as a glucose-responding receptor: loss of boss causes abnormal energy metabolism."
    Kohyama-Koganeya A., Kim Y.J., Miura M., Hirabayashi Y.
    Proc Natl Acad Sci U S A 105:15328-15333(2008) [PubMed] [Europe PMC] [Abstract]
• sevenless signaling pathway Source: FlyBaseInferred from direct assayⁱ
  • "Extracellular domain of the boss transmembrane ligand acts as an antagonist of the sev receptor."
    Hart A.C., Kramer H., Zipursky S.L.
    Nature 361:732-736(1993) [PubMed] [Europe PMC] [Abstract]
• visual perception Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• receptor ligand activity Source: FlyBaseInferred from direct assayⁱ
  • "Extracellular domain of the boss transmembrane ligand acts as an antagonist of the sev receptor."
    Hart A.C., Kramer H., Zipursky S.L.
    Nature 361:732-736(1993) [PubMed] [Europe PMC] [Abstract]
• sevenless binding Source: FlyBaseInferred from direct assayⁱ
  • "Extracellular domain of the boss transmembrane ligand acts as an antagonist of the sev receptor."
    Hart A.C., Kramer H., Zipursky S.L.
    Nature 361:732-736(1993) [PubMed] [Europe PMC] [Abstract]
  • "Oligomerization of the extracellular domain of Boss enhances its binding to the Sevenless receptor and its antagonistic effect on R7 induction."
    Sevrioukov E.A., Walenta J.H., Sunio A., Phistry M., Kramer H.
    J Cell Sci 111:737-747(1998) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MKVMDALQSG RRKPLPVALL CILVTVFCVL ECHGADLTSP TKKSAPLRIT 
        60         70         80         90        100
KPQPTSQQAK PISITTRAPT TVASTTDDEV SSSVDGQLAP LISSTTEGPS 
       110        120        130        140        150
SGTTASLVPE ICLNGLQLTV NSADEGTVIR KQEEFVKILE GDVVLSVLTK 
       160        170        180        190        200
DPDSALFVIN RVNQANLIMA DFEIGIRAIS IDNASLAENL LIQEVQFLQQ 
       210        220        230        240        250
CTTYSMGIFV DWELYKQLES VIKDLEYNIW PIPGTRAHLF PKVAHLLHQM 
       260        270        280        290        300
PWGEKIASVE IATETLEMYN EFMEAARQEH MCLMHFKSDD NVYIMFGNKL 
       310        320        330        340        350
ASHFKENGTL FSVPTDRTDD EFLADLPNRA FVLMENEIDL STAVELDATP 
       360        370        380        390        400
TALDEILIGK SVLPSRVLSF AGSIIDLMNW LRGSLSKHCK RGEEHDLYVL 
       410        420        430        440        450
ESCFNFLNFI EDWRTSEYRQ AHDTAEILSL LLMRKLGTAM NFQMYQKKVL 
       460        470        480        490        500
TLDKITGESR TELREIASQN FVTNVTTYYH YNRDNHTSLE LKTKFGQVFN 
       510        520        530        540        550
CQYSAGDNRR YPFLFDGESV MFWRIKMDTW VATGLTAAIL GLIATLAILV 
       560        570        580        590        600
FIVVRISLGD VFEGNPTTSI LLLLSLILVF CSFVPYSIEY VGEQRNSHVT 
       610        620        630        640        650
FEDAQTLNTL CAVRVFIMTL VYCFVFSLLL CRAVMLASIG SEGGFLSHVN 
       660        670        680        690        700
GYIQAVICAF SVVAQVGMSV QLLVVMHVAS ETVSCENIYY GRWLWGLLAY 
       710        720        730        740        750
DFALLCCVGA LIPSIYRSQR NYREGILIVI GSVLIMVIWV AWIALSLFGD 
       760        770        780        790        800
EWRDAAIPLG LQASGWAVLV GILIPRTFLI VRGIERSDIA QALPSLTSLA 
       810        820        830        840        850
FAQNNQYSSE QSVYECVNPA MRHCSQDEVN HQSPSEIPTL PLRGGGPRRQ 
       860        870        880        890 
QFFANLRQAN ANINPQRPPP RPQQSPSRSS VSSLPPSPDH NKITRF     

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries
2. Drosophila
   Drosophila: entries, gene names and cross-references to FlyBase
3. SIMILARITY comments
   Index of protein domains and families