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Entry version 132 (16 Oct 2019)
Sequence version 2 (01 Nov 1991)
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Protein

ATP-dependent translocase ABCB1

Gene

ABCB1

Organism
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.By similarity

Miscellaneous

PGP isoforms differ in their drug transport capabilities: PGP1 and PGP2 can mediate MDR, while PGP3 apparently cannot.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Translocase activity is inhibited by verapamil and is sensitive to energy depletion.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi424 – 431ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1067 – 1074ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Biological processTransport
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-dependent translocase ABCB1By similarity
Alternative name(s):
ATP-binding cassette sub-family B member 1
Multidrug resistance protein 1 (EC:7.6.2.2)
P-glycoprotein 1
Phospholipid transporter ABCB1Curated (EC:7.6.2.1By similarity)
CD_antigen: CD243
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABCB1By similarity
Synonyms:PGP1, PGY1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10029 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeCricetinaeCricetulus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001075 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 43CytoplasmicBy similarityAdd BLAST43
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei44 – 66HelicalPROSITE-ProRule annotationAdd BLAST23
Topological domaini67 – 113ExtracellularBy similarityAdd BLAST47
Transmembranei114 – 134HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini135 – 183CytoplasmicBy similarityAdd BLAST49
Transmembranei184 – 205HelicalPROSITE-ProRule annotationAdd BLAST22
Topological domaini206 – 212ExtracellularBy similarity7
Transmembranei213 – 233HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini234 – 291CytoplasmicBy similarityAdd BLAST58
Transmembranei292 – 313HelicalPROSITE-ProRule annotationAdd BLAST22
Topological domaini314 – 327ExtracellularBy similarityAdd BLAST14
Transmembranei328 – 349HelicalPROSITE-ProRule annotationAdd BLAST22
Topological domaini350 – 708CytoplasmicBy similarityAdd BLAST359
Transmembranei709 – 729HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini730 – 753ExtracellularBy similarityAdd BLAST24
Transmembranei754 – 774HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini775 – 829CytoplasmicBy similarityAdd BLAST55
Transmembranei830 – 850HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini851ExtracellularBy similarity1
Transmembranei852 – 871HelicalPROSITE-ProRule annotationAdd BLAST20
Topological domaini872 – 931CytoplasmicBy similarityAdd BLAST60
Transmembranei932 – 954HelicalPROSITE-ProRule annotationAdd BLAST23
Topological domaini955 – 970ExtracellularBy similarityAdd BLAST16
Transmembranei971 – 992HelicalPROSITE-ProRule annotationAdd BLAST22
Topological domaini993 – 1276CytoplasmicBy similarityAdd BLAST284

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000933391 – 1276ATP-dependent translocase ABCB1Add BLAST1276

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi87N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei657PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P21448

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at a higher level in intestines than in kidney and liver.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PSMB5.Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10029.NP_001230917.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11276
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P21448

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P21448

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini50 – 354ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST305
Domaini389 – 625ABC transporter 1PROSITE-ProRule annotationAdd BLAST237
Domaini708 – 997ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST290
Domaini1032 – 1270ABC transporter 2PROSITE-ProRule annotationAdd BLAST239

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P21448

KEGG Orthology (KO)

More...
KOi
K05658

Database of Orthologous Groups

More...
OrthoDBi
186078at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030258 MDR1
IPR027417 P-loop_NTPase
IPR039421 Type_I_exporter

The PANTHER Classification System

More...
PANTHERi
PTHR24221 PTHR24221, 1 hit
PTHR24221:SF251 PTHR24221:SF251, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P21448-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEFEEDFSGR KDKNFLKMGR KSKKEKKEKK PVVSVFTMFR YAGWLDRLYM
60 70 80 90 100
LVGTLAAIIH GVALPLMMLV FGDMTDSFAS VGNIPTNATN NATQVNASDI
110 120 130 140 150
FGKLEEEMTT YAYYYTGIGA GVLIVAYIQV SFWCLAAGRQ IHKIRQKFFH
160 170 180 190 200
AIMNQEIGWF DVHDVGELNT RLTDDVSKIN EGIGDKIGMF FQAMATFFGG
210 220 230 240 250
FIIGFTRGWK LTLVILAISP VLGLSAGIWA KILSSFTDKE LQAYAKAGAV
260 270 280 290 300
AEEVLAAIRT VIAFGGQKKE LERYNNNLEE AKRLGIKKAI TANISMGAAF
310 320 330 340 350
LLIYASYALA FWYGTSLVIS KEYSIGQVLT VFFAVLIGAF SIGQASPNIE
360 370 380 390 400
AFANARGAAY EIFNIIDNKP SIDSFSKNGY KPDNIKGNLE FKNIHFSYPS
410 420 430 440 450
RKDVQILKGL NLKVQSGQTV ALVGNSGCGK STTVQLLQRL YDPTEGVVSI
460 470 480 490 500
DGQDIRTINV RYLREIIGVV SQEPVLFATT IAENIRYGRE NVTMDEIEKA
510 520 530 540 550
VKEANAYDFI MKLPHKFDTL VGERGAQLSG GQKQRIAIAR ALVRNPKILL
560 570 580 590 600
LDEATSALDT ESEAVVQAAL DKAREGRTTI VIAHRLSTVR NADIIAGFDG
610 620 630 640 650
GVIVEQGNHE ELMREKGIYF KLVMTQTAGN EIELGNEVGE SKNEIDNLDM
660 670 680 690 700
SSKDSASSLI RRRSTRRSIR GPHDQDRKLS TKEALDEDVP PISFWRILKL
710 720 730 740 750
NSSEWPYFVV GIFCAIVNGA LQPAFSIIFS KVVGVFTRNT DDETKRHDSN
760 770 780 790 800
LFSLLFLILG VISFITFFLQ GFTFGKAGEI LTKRLRYMVF KSMLRQDVSW
810 820 830 840 850
FDNPKNTTGA LTTRLANDAG QVKGATGARL AVITQNIANL GTGIIISLIY
860 870 880 890 900
GWQLTLLLLA IVPIIAIAGV VEMKMLSGQA LKDKKELEGS GKIATEAIEN
910 920 930 940 950
FRTVVSLTRE QKFENMYAQS LQIPYRNALK KAHVFGITFS FTQAMMYFSY
960 970 980 990 1000
AACFRFGAYL VARELMTFEN VLLVFSAIVF GAMAVGQVSS FAPDYAKAKV
1010 1020 1030 1040 1050
SASHIIMIIE KVPSIDSYST GGLKPNTLEG NVKFNEVVFN YPTRPDIPVL
1060 1070 1080 1090 1100
QGLNLEVKKG QTLALVGSSG CGKSTVVQLL ERFYDPMAGT VFLDGKEVNQ
1110 1120 1130 1140 1150
LNVQWLRAHL GIVSQEPILF DCSIAENIAY GDNSRVVSQD EIERAAKEAN
1160 1170 1180 1190 1200
IHQFIESLPD KYNTRVGDKG TQLSGGQKQR IAIARALVRQ PHILLLDEAT
1210 1220 1230 1240 1250
SALDTESEKV VQEALDKARE GRTCIVIAHR LSTIQNADLI VVIQNGKVKE
1260 1270
HGTHQQLLAQ KGIYFSMVSV QAGAKR
Length:1,276
Mass (Da):140,926
Last modified:November 1, 1991 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i44F3F92A186B4DFF
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence EGW07208 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti338 – 339GA → AP in AAA37004 (PubMed:1671863).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M60040 mRNA Translation: AAA68883.1
M59253 mRNA Translation: AAA37004.1
JH000645 Genomic DNA Translation: EGW07208.1 Sequence problems.
AH003795 Genomic DNA Translation: AAP32275.1
L03286 Genomic DNA No translation available.
M17897 mRNA Translation: AAA37006.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A38696 DVHY1C

NCBI Reference Sequences

More...
RefSeqi
NP_001230917.1, NM_001243988.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCGRT00015001185; ENSCGRP00015000926; ENSCGRG00015000706

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100682536

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cge:100682536

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60040 mRNA Translation: AAA68883.1
M59253 mRNA Translation: AAA37004.1
JH000645 Genomic DNA Translation: EGW07208.1 Sequence problems.
AH003795 Genomic DNA Translation: AAP32275.1
L03286 Genomic DNA No translation available.
M17897 mRNA Translation: AAA37006.1
PIRiA38696 DVHY1C
RefSeqiNP_001230917.1, NM_001243988.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MVUX-ray1.78P1210-1222[»]
2AP2X-ray2.40P/Q1210-1223[»]
SMRiP21448
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi10029.NP_001230917.1

Proteomic databases

PRIDEiP21448

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P21448

Genome annotation databases

EnsembliENSCGRT00015001185; ENSCGRP00015000926; ENSCGRG00015000706
GeneIDi100682536
KEGGicge:100682536

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5243

Phylogenomic databases

InParanoidiP21448
KOiK05658
OrthoDBi186078at2759

Miscellaneous databases

EvolutionaryTraceiP21448

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030258 MDR1
IPR027417 P-loop_NTPase
IPR039421 Type_I_exporter
PANTHERiPTHR24221 PTHR24221, 1 hit
PTHR24221:SF251 PTHR24221:SF251, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMDR1_CRIGR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21448
Secondary accession number(s): G3HRY0, Q80W58
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: November 1, 1991
Last modified: October 16, 2019
This is version 132 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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