P20047 · CADC_STAAU

  • Protein
    Cadmium resistance transcriptional regulatory protein CadC
  • Gene
    cadC
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Metal-binding repressor for the cad operon. Involved in resistance to heavy metals, such as cadmium, bismuth, zinc or lead. Binds 2 metal ions per subunit. Metal binding to the N-terminal regulatory site causes the repressor to dissociate from the DNA.

Miscellaneous

The N-terminal, regulatory metal binding site 1 has higher affinity for cadmium than for zinc. The second metal binding site has higher affinity for zinc and has no regulatory function.

Features

Showing features for binding site, dna binding.

1122102030405060708090100110120
Type
IDPosition(s)Description
Binding site7Cd2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site11Cd2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site58Cd2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
DNA binding59-78H-T-H motif
Binding site60Cd2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site101Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site103Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site114Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site117Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners

GO annotations

AspectTerm
Molecular FunctionDNA binding
Molecular FunctionDNA-binding transcription factor activity
Molecular Functionmetal ion binding
Biological Processresponse to cadmium ion

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cadmium resistance transcriptional regulatory protein CadC
  • Alternative names
    • Cadmium efflux system accessory protein

Gene names

    • Name
      cadC

Encoded on

  • Plasmid pI258

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Bacteria > Bacillati > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus

Accessions

  • Primary accession
    P20047

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis7Abolishes dissociation from DNA; when associated with G-11; S-58 and S-60.
Mutagenesis11No effect. Abolishes dissociation from DNA; when associated with S-7; S-58 and S-60.
Mutagenesis58Abolishes dissociation from DNA; when associated with S-7; G-11 and S-60.
Mutagenesis60Abolishes dissociation from DNA; when associated with S-7; G-11 and S-58.
Mutagenesis101No effect on repressor activity; when associated with A-103.
Mutagenesis103No effect on repressor activity; when associated with G-101.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001606201-122Cadmium resistance transcriptional regulatory protein CadC

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain24-119HTH arsR-type

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    122
  • Mass (Da)
    13,779
  • Last updated
    1991-02-01 v1
  • MD5 Checksum
    ED3942C77A4814591F1EACF5D3C36866
MKKKDTCEIFCYDEEKVNRIQGDLQTVDISGVSQILKAIADENRAKITYALCQDEELCVCDIANILGVTIANASHHLRTLYKQGVVNFRKEGKLALYSLGDEHIRQIMMIALAHKKEVKVNV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
J04551
EMBL· GenBank· DDBJ
AAB59153.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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