CD36

Functionⁱ

Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (By similarity) (PubMed:18353783, PubMed:21610069). In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway (By similarity) (PubMed:18753675). Involved in oral fat perception and preferences (PubMed:22240721, PubMed:25822988). Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions (By similarity). In taste receptor cells, mediates the induction of an increase in intracellular calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract (By similarity). Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis (By similarity). Receptor for thombospondins, THBS1 and THBS2, mediating their antiangiogenic effects (By similarity). As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome (By similarity) (PubMed:20037584). Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (By similarity) (PubMed:16880211).By similarity1 Publication8 Publications

(Microbial infection) Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and the internalization of particles independently of TLR signaling.3 Publications

Catalytic activityⁱ

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	463	Critical for TLR4-TLR6 dimerization and signaling1 Publication		1

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor
Biological process	Cell adhesion, Transport

Enzyme and pathway databases

PathwayCommonsⁱ	P16671
Reactomeⁱ	R-HSA-114608, Platelet degranulation R-HSA-1236973, Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236974, ER-Phagosome pathway R-HSA-166058, MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-168188, Toll Like Receptor TLR6:TLR2 Cascade R-HSA-1989781, PPARA activates gene expression R-HSA-3000471, Scavenging by Class B Receptors R-HSA-381340, Transcriptional regulation of white adipocyte differentiation R-HSA-434313, Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-5602498, MyD88 deficiency (TLR2/4) R-HSA-5603041, IRAK4 deficiency (TLR2/4) R-HSA-5686938, Regulation of TLR by endogenous ligand R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-6798695, Neutrophil degranulation
SIGNORⁱ	P16671

Protein family/group databases

TCDBⁱ	9.B.39.1.4, the long chain fatty acid translocase (lcfat) family

TCDBⁱ

9.B.39.1.4, the long chain fatty acid translocase (lcfat) family

Chemistry databases

SwissLipidsⁱ	SLP:000001098

SwissLipidsⁱ

SLP:000001098

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Platelet glycoprotein 4 Alternative name(s): Fatty acid translocase Short name: FAT Glycoprotein IIIb Short name: GPIIIB Leukocyte differentiation antigen CD36 PAS IV PAS-4 Platelet collagen receptor Platelet glycoprotein IV Short name: GPIV Thrombospondin receptor CD_antigen: CD36
Gene namesⁱ	Name:CD36 Synonyms:GP3B, GP4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1663, CD36
MIMⁱ	173510, gene
neXtProtⁱ	NX_P16671
VEuPathDBⁱ	HostDB:ENSG00000135218.17

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	2 – 7	CytoplasmicSequence analysis	6
Transmembraneⁱ	8 – 29	HelicalSequence analysisAdd BLAST	22
Topological domainⁱ	30 – 439	ExtracellularSequence analysisAdd BLAST	410
Transmembraneⁱ	440 – 461	HelicalSequence analysisAdd BLAST	22
Topological domainⁱ	462 – 472	CytoplasmicSequence analysisAdd BLAST	11

Keywords - Cellular componentⁱ

Cell membrane, Golgi apparatus, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Platelet glycoprotein IV deficiency (PG4D)2 Publications

The disease is caused by variants affecting the gene represented in this entry. Patients also have postprandial hypertriglyceridemia, insulin resistance and hypertension increasing atherosclerotic risk.1 Publication

Disease descriptionA disorder characterized by macrothrombocytopenia without notable hemostatic problems and bleeding tendency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal.

Related information in OMIM

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_017913	90	P → S in PG4D; type I; degradation in the cytoplasm due to defects in maturation. 2 PublicationsCorresponds to variant dbSNP:rs75326924EnsemblClinVar.	1
Natural variantⁱVAR_017917	254	F → L in PG4D; type I. 1 PublicationCorresponds to variant dbSNP:rs142186404EnsemblClinVar.	1
Natural variantⁱVAR_017919	413	I → L in PG4D; type I. 1 PublicationCorresponds to variant dbSNP:rs121918035EnsemblClinVar.	1

Coronary heart disease 7 (CHDS7)1 Publication

Disease susceptibility is associated with variants affecting the gene represented in this entry.

Disease descriptionA multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries.

Related information in OMIM

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	462 – 472	SYCACRSKTIK → AAAAAAAAAAA: No effect on cell surface location. Loss of oxLDL-induced NF-kappa-B activation. 1 PublicationAdd BLAST	11
Mutagenesisⁱ	463	Y → A: No effect on cell surface location. Loss of oxLDL-induced NF-kappa-B activation. Loss of complex formation with TLR4 and TLR6. 1 Publication	1
Mutagenesisⁱ	464	C → S: No effect on cell surface location, nor on oxLDL-induced NF-kappa-B activation. 1 Publication	1
Mutagenesisⁱ	469 – 472	KTIK → ATIA: Abolishes ubiquitination induced by lipids. Enhances fatty acid uptake. 2 Publications	4

Keywords - Diseaseⁱ

Disease variant

Organism-specific databases

DisGeNET More...DisGeNETⁱ	948
MalaCards human disease database More...MalaCardsⁱ	CD36
MIMⁱ	248310, phenotype 608404, phenotype 610938, phenotype 611162, phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000135218
PharmGKBⁱ	PA26212

Miscellaneous databases

Pharosⁱ	P16671, Tbio

Pharosⁱ

P16671, Tbio

Chemistry databases

ChEMBLⁱ	CHEMBL1744526

ChEMBLⁱ

CHEMBL1744526

Genetic variation databases

BioMutaⁱ	CD36
DMDMⁱ	115982

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000144151	2 – 472	Platelet glycoprotein 4Add BLAST		471

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Lipidationⁱ	3	S-palmitoyl cysteine1 Publication	1
Lipidationⁱ	7	S-palmitoyl cysteine1 Publication	1
Glycosylationⁱ	79	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	102	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	134	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	163	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	205	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	220	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	235	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	243 ↔ 311	By similarity
Glycosylationⁱ	247	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	272 ↔ 333	By similarity
Disulfide bondⁱ	313 ↔ 322	By similarity
Glycosylationⁱ	321	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	417	N-linked (GlcNAc...) asparagine2 Publications	1
Lipidationⁱ	464	S-palmitoyl cysteine1 Publication	1
Lipidationⁱ	466	S-palmitoyl cysteine1 Publication	1
Cross-linkⁱ	469	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications
Cross-linkⁱ	472	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications

Post-translational modificationⁱ

N-glycosylated and O-glycosylated with a ratio of 2:1.4 Publications

Ubiquitinated at Lys-469 and Lys-472. Ubiquitination is induced by fatty acids such as oleic acid and leads to degradation by the proteasome (PubMed:21610069, PubMed:18353783). Ubiquitination and degradation are inhibited by insulin which blocks the effect of fatty acids (PubMed:18353783).2 Publications

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Isopeptide bond, Lipoprotein, Palmitate, Ubl conjugation

Proteomic databases

jPOSTⁱ	P16671
MassIVEⁱ	P16671
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P16671
PaxDbⁱ	P16671
PeptideAtlas More...PeptideAtlasⁱ	P16671
PRIDEⁱ	P16671
ProteomicsDBⁱ	15177 15178 53392 [P16671-1]

PTM databases

GlyConnectⁱ	1611, 20 N-Linked glycans (3 sites)
GlyGenⁱ	P16671, 10 sites, 1 N-linked glycan (1 site)
iPTMnetⁱ	P16671
PhosphoSitePlusⁱ	P16671
SwissPalmⁱ	P16671

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000135218, Expressed in adipose tissue and 213 other tissues
ExpressionAtlasⁱ	P16671, baseline and differential
Genevisibleⁱ	P16671, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000135218, Tissue enhanced (adipose tissue, breast)

HPAⁱ

ENSG00000135218, Tissue enhanced (adipose tissue, breast)

Interactionⁱ

Subunit structureⁱ

Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity (PubMed:1371676). Upon interaction with a ligand, such as oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42, rapidly forms a complex with TLR4 and TLR6; the complex is internalized and triggers an inflammatory signal. Through its C-terminus, interacts with PTK2, PXN and LYN, but not with SRC. LYN kinase activity is required for facilitating TLR4:TLR6 heterodimerization and signal initiation (PubMed:1371676, PubMed:20037584). Upon interaction with ligands such as diacylated lipopeptides, interacts with the TLR2:TLR6 heterodimer (PubMed:16880211).

Interacts with CD9, CD81, FCER1G, ITGB2 and/or ITGB2; forming a membrane heteromeric complex required for the internalization of CD36 and its ligands (By similarity).

By similarity3 Publications

(Microbial infection) Binds to Plasmodium falciparum EMP1.

1 Publication

Binary interactionsⁱ

Hide details

P16671

With	#Exp.	IntAct
APP [P05067]	3	EBI-2808214,EBI-77613
LYN [P07948]	3	EBI-2808214,EBI-79452
Thrombospondin-1 (PRO_0000035842)	2	EBI-2808214,EBI-13915509
UNG - isoform 1 [P13051-2]	3	EBI-2808214,EBI-25834258

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	107386, 21 interactors
IntActⁱ	P16671, 20 interactors
STRINGⁱ	9606.ENSP00000399421

Chemistry databases

BindingDBⁱ

P16671

Miscellaneous databases

RNActⁱ	P16671, protein

RNActⁱ

P16671, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	38 – 41	Combined sources	4
Beta strandⁱ	42 – 45	Combined sources	4
Helixⁱ	49 – 55	Combined sources	7
Beta strandⁱ	61 – 71	Combined sources	11
Helixⁱ	73 – 79	Combined sources	7
Beta strandⁱ	83 – 96	Combined sources	14
Beta strandⁱ	101 – 106	Combined sources	6
Turnⁱ	107 – 110	Combined sources	4
Beta strandⁱ	111 – 117	Combined sources	7
Beta strandⁱ	120 – 122	Combined sources	3
Helixⁱ	124 – 126	Combined sources	3
Beta strandⁱ	127 – 129	Combined sources	3
Beta strandⁱ	134 – 138	Combined sources	5
Helixⁱ	140 – 148	Combined sources	9
Helixⁱ	152 – 164	Combined sources	13
Beta strandⁱ	169 – 174	Combined sources	6
Helixⁱ	175 – 180	Combined sources	6
Helixⁱ	187 – 189	Combined sources	3
Beta strandⁱ	208 – 215	Combined sources	8
Helixⁱ	221 – 223	Combined sources	3
Beta strandⁱ	227 – 230	Combined sources	4
Beta strandⁱ	233 – 235	Combined sources	3
Beta strandⁱ	237 – 240	Combined sources	4
Helixⁱ	241 – 244	Combined sources	4
Beta strandⁱ	251 – 253	Combined sources	3
Beta strandⁱ	263 – 268	Combined sources	6
Turnⁱ	269 – 272	Combined sources	4
Beta strandⁱ	273 – 285	Combined sources	13
Beta strandⁱ	288 – 294	Combined sources	7
Helixⁱ	297 – 300	Combined sources	4
Turnⁱ	303 – 305	Combined sources	3
Helixⁱ	307 – 312	Combined sources	6
Turnⁱ	317 – 323	Combined sources	7
Beta strandⁱ	326 – 329	Combined sources	4
Helixⁱ	331 – 333	Combined sources	3
Turnⁱ	334 – 336	Combined sources	3
Beta strandⁱ	339 – 342	Combined sources	4
Helixⁱ	344 – 346	Combined sources	3
Helixⁱ	351 – 354	Combined sources	4
Beta strandⁱ	357 – 359	Combined sources	3
Helixⁱ	364 – 367	Combined sources	4
Beta strandⁱ	370 – 373	Combined sources	4
Turnⁱ	375 – 377	Combined sources	3
Beta strandⁱ	379 – 393	Combined sources	15
Helixⁱ	400 – 402	Combined sources	3
Beta strandⁱ	409 – 421	Combined sources	13
Helixⁱ	424 – 433	Combined sources	10

Show more details

3D structure databases

SMRⁱ	P16671
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	93 – 120	Required for interaction with thrombospondins, THBS1 and THBS21 PublicationAdd BLAST		28
Regionⁱ	460 – 472	Interaction with PTK2, PXN and LYN1 PublicationAdd BLAST		13

Sequence similaritiesⁱ

Belongs to the CD36 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3776, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000153372
HOGENOMⁱ	CLU_019853_0_0_1
InParanoidⁱ	P16671
OMAⁱ	MIAYCVC
Database of Orthologous Groups More...OrthoDBⁱ	1106566at2759
PhylomeDBⁱ	P16671
TreeFamⁱ	TF317925

Family and domain databases

InterProⁱ	View protein in InterPro IPR005428, CD36/SCARB1/SNMP1 IPR033076, CD36_chordates IPR002159, CD36_fam
PANTHERⁱ	PTHR11923, PTHR11923, 1 hit PTHR11923:SF12, PTHR11923:SF12, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01130, CD36, 1 hit
PRINTSⁱ	PR01610, CD36ANTIGEN PR01609, CD36FAMILY

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 9 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P16671-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGCDRNCGLI AGAVIGAVLA VFGGILMPVG DLLIQKTIKK QVVLEEGTIA 
        60         70         80         90        100
FKNWVKTGTE VYRQFWIFDV QNPQEVMMNS SNIQVKQRGP YTYRVRFLAK 
       110        120        130        140        150
ENVTQDAEDN TVSFLQPNGA IFEPSLSVGT EADNFTVLNL AVAAASHIYQ 
       160        170        180        190        200
NQFVQMILNS LINKSKSSMF QVRTLRELLW GYRDPFLSLV PYPVTTTVGL 
       210        220        230        240        250
FYPYNNTADG VYKVFNGKDN ISKVAIIDTY KGKRNLSYWE SHCDMINGTD 
       260        270        280        290        300
AASFPPFVEK SQVLQFFSSD ICRSIYAVFE SDVNLKGIPV YRFVLPSKAF 
       310        320        330        340        350
ASPVENPDNY CFCTEKIISK NCTSYGVLDI SKCKEGRPVY ISLPHFLYAS 
       360        370        380        390        400
PDVSEPIDGL NPNEEEHRTY LDIEPITGFT LQFAKRLQVN LLVKPSEKIQ 
       410        420        430        440        450
VLKNLKRNYI VPILWLNETG TIGDEKANMF RSQVTGKINL LGLIEMILLS 
       460        470 
VGVVMFVAFM ISYCACRSKT IK

Length:472

Mass (Da):53,053

Last modified:January 23, 2007 - v2

Checksum:ⁱ543E748259A094FA

GO

Isoform 2 (identifier: P16671-2) [UniParc]FASTA Add to basket

Also known as: ex8-del

The sequence of this isoform differs from the canonical sequence as follows:
274-288: SIYAVFESDVNLKGI → ETCVHFTSSFSVCKS
289-472: Missing.

« Hide

        10         20         30         40         50
MGCDRNCGLI AGAVIGAVLA VFGGILMPVG DLLIQKTIKK QVVLEEGTIA 
        60         70         80         90        100
FKNWVKTGTE VYRQFWIFDV QNPQEVMMNS SNIQVKQRGP YTYRVRFLAK 
       110        120        130        140        150
ENVTQDAEDN TVSFLQPNGA IFEPSLSVGT EADNFTVLNL AVAAASHIYQ 
       160        170        180        190        200
NQFVQMILNS LINKSKSSMF QVRTLRELLW GYRDPFLSLV PYPVTTTVGL 
       210        220        230        240        250
FYPYNNTADG VYKVFNGKDN ISKVAIIDTY KGKRNLSYWE SHCDMINGTD 
       260        270        280 
AASFPPFVEK SQVLQFFSSD ICRETCVHFT SSFSVCKS

Show »

Length:288

Mass (Da):32,265

Checksum:ⁱC82FFEF32AF7A690

GO

Isoform 3 (identifier: P16671-3) [UniParc]FASTA Add to basket

Also known as: ex6-7-del

The sequence of this isoform differs from the canonical sequence as follows:
234-272: Missing.

« Hide

        10         20         30         40         50
MGCDRNCGLI AGAVIGAVLA VFGGILMPVG DLLIQKTIKK QVVLEEGTIA 
        60         70         80         90        100
FKNWVKTGTE VYRQFWIFDV QNPQEVMMNS SNIQVKQRGP YTYRVRFLAK 
       110        120        130        140        150
ENVTQDAEDN TVSFLQPNGA IFEPSLSVGT EADNFTVLNL AVAAASHIYQ 
       160        170        180        190        200
NQFVQMILNS LINKSKSSMF QVRTLRELLW GYRDPFLSLV PYPVTTTVGL 
       210        220        230        240        250
FYPYNNTADG VYKVFNGKDN ISKVAIIDTY KGKRSIYAVF ESDVNLKGIP 
       260        270        280        290        300
VYRFVLPSKA FASPVENPDN YCFCTEKIIS KNCTSYGVLD ISKCKEGRPV 
       310        320        330        340        350
YISLPHFLYA SPDVSEPIDG LNPNEEEHRT YLDIEPITGF TLQFAKRLQV 
       360        370        380        390        400
NLLVKPSEKI QVLKNLKRNY IVPILWLNET GTIGDEKANM FRSQVTGKIN 
       410        420        430 
LLGLIEMILL SVGVVMFVAF MISYCACRSK TIK

Show »

Length:433

Mass (Da):48,600

Checksum:ⁱ9D4A561C95F1ED4D

GO

Isoform 4 (identifier: P16671-4) [UniParc]FASTA Add to basket

Also known as: ex4-del

The sequence of this isoform differs from the canonical sequence as follows:
144-203: Missing.

« Hide

        10         20         30         40         50
MGCDRNCGLI AGAVIGAVLA VFGGILMPVG DLLIQKTIKK QVVLEEGTIA 
        60         70         80         90        100
FKNWVKTGTE VYRQFWIFDV QNPQEVMMNS SNIQVKQRGP YTYRVRFLAK 
       110        120        130        140        150
ENVTQDAEDN TVSFLQPNGA IFEPSLSVGT EADNFTVLNL AVAYNNTADG 
       160        170        180        190        200
VYKVFNGKDN ISKVAIIDTY KGKRNLSYWE SHCDMINGTD AASFPPFVEK 
       210        220        230        240        250
SQVLQFFSSD ICRSIYAVFE SDVNLKGIPV YRFVLPSKAF ASPVENPDNY 
       260        270        280        290        300
CFCTEKIISK NCTSYGVLDI SKCKEGRPVY ISLPHFLYAS PDVSEPIDGL 
       310        320        330        340        350
NPNEEEHRTY LDIEPITGFT LQFAKRLQVN LLVKPSEKIQ VLKNLKRNYI 
       360        370        380        390        400
VPILWLNETG TIGDEKANMF RSQVTGKINL LGLIEMILLS VGVVMFVAFM 
       410 
ISYCACRSKT IK

Show »

Length:412

Mass (Da):46,090

Checksum:ⁱ33D8CA7991537066

GO

Computationally mapped potential isoform sequencesⁱ

There are 9 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PLT1	E9PLT1_HUMAN	Glycoprotein IIIb Glycoprotein IIIb (PAS IV) (PAS-4) (Platelet glycoprotein 4) (Platelet glycoprotein IV)	CD36	396	Annotation score:
E7EU05	E7EU05_HUMAN	Glycoprotein IIIb Glycoprotein IIIb (PAS IV) (PAS-4) (Platelet glycoprotein 4) (Platelet glycoprotein IV)	CD36	463	Annotation score:
H0YEE7	H0YEE7_HUMAN	Glycoprotein IIIb Glycoprotein IIIb (PAS IV) (PAS-4) (Platelet glycoprotein 4) (Platelet glycoprotein IV)	CD36	66	Annotation score:
E7EX47	E7EX47_HUMAN	Glycoprotein IIIb Glycoprotein IIIb (PAS IV) (PAS-4) (Platelet glycoprotein 4) (Platelet glycoprotein IV)	CD36	203	Annotation score:
E7ERZ9	E7ERZ9_HUMAN	Glycoprotein IIIb Glycoprotein IIIb (PAS IV) (PAS-4) (Platelet glycoprotein 4) (Platelet glycoprotein IV)	CD36	143	Annotation score:
E7EVU1	E7EVU1_HUMAN	Glycoprotein IIIb Glycoprotein IIIb (PAS IV) (PAS-4) (Platelet glycoprotein 4) (Platelet glycoprotein IV)	CD36	99	Annotation score:
E7EWI4	E7EWI4_HUMAN	Glycoprotein IIIb Glycoprotein IIIb (PAS IV) (PAS-4) (Platelet glycoprotein 4) (Platelet glycoprotein IV)	CD36	148	Annotation score:
E9PC45	E9PC45_HUMAN	Glycoprotein IIIb Glycoprotein IIIb (PAS IV) (PAS-4) (Platelet glycoprotein 4) (Platelet glycoprotein IV)	CD36	93	Annotation score:
E9PJX8	E9PJX8_HUMAN	Glycoprotein IIIb Glycoprotein IIIb (PAS IV) (PAS-4) (Platelet glycoprotein 4) (Platelet glycoprotein IV)	CD36	65	Annotation score:

Sequence cautionⁱ

The sequence AAM14636 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	44	L → R in AAD13993 (PubMed:7505064).Curated	1
Sequence conflictⁱ	238	Y → D in AAD13993 (PubMed:7505064).Curated	1
Sequence conflictⁱ	374	E → Q in AAA16068 (PubMed:7693552).Curated	1
Sequence conflictⁱ	374	E → Q AA sequence (PubMed:15242332).Curated	1

Polymorphismⁱ

Genetic variations in CD36 are involved in susceptibility to malaria and influence the severity and outcome of malaria infection [MIMⁱ:611162].

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_017913	90	P → S in PG4D; type I; degradation in the cytoplasm due to defects in maturation. 2 PublicationsCorresponds to variant dbSNP:rs75326924EnsemblClinVar.	1
Natural variantⁱVAR_017914	123	E → K in individuals from a malaria endemic area in West Africa. 1 PublicationCorresponds to variant dbSNP:rs183461468Ensembl.	1
Natural variantⁱVAR_019049	127	S → L1 PublicationCorresponds to variant dbSNP:rs201765331Ensembl.	1
Natural variantⁱVAR_013918	154	V → F1 PublicationCorresponds to variant dbSNP:rs5957Ensembl.	1
Natural variantⁱVAR_017915	174	T → A in individuals from a malaria endemic area in West Africa. 1 PublicationCorresponds to variant dbSNP:rs756525492Ensembl.	1
Natural variantⁱVAR_017916	232	G → GN in individuals from a malaria endemic area in West Africa. 1 Publication	1
Natural variantⁱVAR_017917	254	F → L in PG4D; type I. 1 PublicationCorresponds to variant dbSNP:rs142186404EnsemblClinVar.	1
Natural variantⁱVAR_017918	271	I → T in individuals from a malaria endemic area in West Africa. 1 PublicationCorresponds to variant dbSNP:rs370072057Ensembl.	1
Natural variantⁱVAR_071161	386	R → W1 PublicationCorresponds to variant dbSNP:rs148910227EnsemblClinVar.	1
Natural variantⁱVAR_017919	413	I → L in PG4D; type I. 1 PublicationCorresponds to variant dbSNP:rs121918035EnsemblClinVar.	1
Natural variantⁱVAR_071162	470	T → I1 PublicationCorresponds to variant dbSNP:rs200771788Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_055976	144 – 203	Missing in isoform 4. 1 PublicationAdd BLAST	60
Alternative sequenceⁱVSP_055977	234 – 272	Missing in isoform 3. 1 PublicationAdd BLAST	39
Alternative sequenceⁱVSP_055978	274 – 288	SIYAV…NLKGI → ETCVHFTSSFSVCKS in isoform 2. 1 PublicationAdd BLAST	15
Alternative sequenceⁱVSP_055979	289 – 472	Missing in isoform 2. 1 PublicationAdd BLAST	184

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M24795 mRNA Translation: AAA35534.1 M98398 mRNA Translation: AAA58412.1 M98399 mRNA Translation: AAA58413.1 L06850 mRNA Translation: AAA16068.1 S67532 mRNA Translation: AAD13993.1 Z32770 Z32764 Genomic DNA Translation: CAA83662.1 AY095373 Genomic DNA Translation: AAM14636.2 Frameshift. HM217023 mRNA Translation: ADI80543.1 HM217024 mRNA Translation: ADI80544.1 HM217025 mRNA Translation: ADI80545.1 HM217026 mRNA Translation: ADI80546.1 AC004862 Genomic DNA No translation available. AC073182 Genomic DNA No translation available. AC073850 Genomic DNA No translation available. AC092108 Genomic DNA No translation available. AC124834 Genomic DNA No translation available. BC008406 mRNA Translation: AAH08406.1 AF300626 Genomic DNA Translation: AAG60625.1 AF300627 Genomic DNA Translation: AAG60626.1 AF300628 Genomic DNA Translation: AAG60627.1 AF300633 Genomic DNA Translation: AAG60632.1 AF300634 Genomic DNA Translation: AAG60633.1 AF300635 Genomic DNA Translation: AAG60634.1 AF300639 Genomic DNA Translation: AAG60638.1 AF300640 Genomic DNA Translation: AAG60639.1 S67044 mRNA Translation: AAB28992.1 Z22924 Genomic DNA Translation: CAA80504.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34673.1 [P16671-1] CCDS78249.1 [P16671-3] CCDS78250.1 [P16671-4]
PIRⁱ	A54870
NCBI Reference Sequences More...RefSeqⁱ	NP_000063.2, NM_000072.3 [P16671-1] NP_001001547.1, NM_001001547.2 [P16671-1] NP_001001548.1, NM_001001548.2 [P16671-1] NP_001120915.1, NM_001127443.1 [P16671-1] NP_001120916.1, NM_001127444.1 [P16671-1] NP_001276837.1, NM_001289908.1 [P16671-3] NP_001276838.1, NM_001289909.1 [P16671-4] NP_001276840.1, NM_001289911.1 XP_005250770.1, XM_005250713.1 XP_005250771.1, XM_005250714.1 XP_005250772.1, XM_005250715.4 [P16671-1]

Genome annotation databases

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P16671	Glycoprotein IIIb		HUMAN		472	UniRef100_P16671
Glycoprotein IIIb (Fragment)		PONAB		65
Glycoprotein IIIb (Fragment)		PANTR		65
Glycoprotein IIIb (Fragment)		HUMAN		463
Glycoprotein IIIb (Fragment)		HUMAN		203
+14

Protein	Similar proteins		Species	Score	Length	Source
P16671	Glycoprotein IIIb		HUMAN		472	UniRef90_P16671
Glycoprotein IIIb (Fragment)		PONAB		65
Glycoprotein IIIb (Fragment)		PANTR		65
Glycoprotein IIIb		CHLSB		473
Glycoprotein IIIb		COLAP		472
+98
P16671-2	Glycoprotein IIIb		AOTNA		289	UniRef90_P16671-2
Glycoprotein IIIb		MACNE		288
Glycoprotein IIIb		SAIBB		288
Glycoprotein IIIb		NOMLE		288
Glycoprotein IIIb		GORGO		288
+12

Protein	Similar proteins		Species	Score	Length	Source
P16671	Platelet glycoprotein 4		MESAU		472	UniRef50_P16671
Platelet glycoprotein 4		MOUSE		472
Platelet glycoprotein 4		RAT		472
Glycoprotein IIIb		HUMAN		472
Glycoprotein IIIb (Fragment)		PONAB		65
+505
P16671-2	Glycoprotein IIIb		AOTNA		289	UniRef50_P16671-2
Glycoprotein IIIb		CALJA		288
Glycoprotein IIIb		PAPAN		288
Glycoprotein IIIb		CERAT		288
Glycoprotein IIIb		MANLE		288
+28

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

CD36 entry

SeattleSNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M24795 mRNA Translation: AAA35534.1 M98398 mRNA Translation: AAA58412.1 M98399 mRNA Translation: AAA58413.1 L06850 mRNA Translation: AAA16068.1 S67532 mRNA Translation: AAD13993.1 Z32770 Z32764 Genomic DNA Translation: CAA83662.1 AY095373 Genomic DNA Translation: AAM14636.2 Frameshift. HM217023 mRNA Translation: ADI80543.1 HM217024 mRNA Translation: ADI80544.1 HM217025 mRNA Translation: ADI80545.1 HM217026 mRNA Translation: ADI80546.1 AC004862 Genomic DNA No translation available. AC073182 Genomic DNA No translation available. AC073850 Genomic DNA No translation available. AC092108 Genomic DNA No translation available. AC124834 Genomic DNA No translation available. BC008406 mRNA Translation: AAH08406.1 AF300626 Genomic DNA Translation: AAG60625.1 AF300627 Genomic DNA Translation: AAG60626.1 AF300628 Genomic DNA Translation: AAG60627.1 AF300633 Genomic DNA Translation: AAG60632.1 AF300634 Genomic DNA Translation: AAG60633.1 AF300635 Genomic DNA Translation: AAG60634.1 AF300639 Genomic DNA Translation: AAG60638.1 AF300640 Genomic DNA Translation: AAG60639.1 S67044 mRNA Translation: AAB28992.1 Z22924 Genomic DNA Translation: CAA80504.1
CCDSⁱ	CCDS34673.1 [P16671-1] CCDS78249.1 [P16671-3] CCDS78250.1 [P16671-4]
PIRⁱ	A54870
RefSeqⁱ	NP_000063.2, NM_000072.3 [P16671-1] NP_001001547.1, NM_001001547.2 [P16671-1] NP_001001548.1, NM_001001548.2 [P16671-1] NP_001120915.1, NM_001127443.1 [P16671-1] NP_001120916.1, NM_001127444.1 [P16671-1] NP_001276837.1, NM_001289908.1 [P16671-3] NP_001276838.1, NM_001289909.1 [P16671-4] NP_001276840.1, NM_001289911.1 XP_005250770.1, XM_005250713.1 XP_005250771.1, XM_005250714.1 XP_005250772.1, XM_005250715.4 [P16671-1]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5LGD	X-ray	2.07	A	1-472	[»]
SMRⁱ	P16671
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	107386, 21 interactors
IntActⁱ	P16671, 20 interactors
STRINGⁱ	9606.ENSP00000399421

Chemistry databases

BindingDBⁱ	P16671
ChEMBLⁱ	CHEMBL1744526
SwissLipidsⁱ	SLP:000001098

Protein family/group databases

TCDBⁱ	9.B.39.1.4, the long chain fatty acid translocase (lcfat) family

TCDBⁱ

9.B.39.1.4, the long chain fatty acid translocase (lcfat) family

PTM databases

GlyConnectⁱ	1611, 20 N-Linked glycans (3 sites)
GlyGenⁱ	P16671, 10 sites, 1 N-linked glycan (1 site)
iPTMnetⁱ	P16671
PhosphoSitePlusⁱ	P16671
SwissPalmⁱ	P16671

Genetic variation databases

BioMutaⁱ	CD36
DMDMⁱ	115982

Proteomic databases

jPOSTⁱ	P16671
MassIVEⁱ	P16671
MaxQBⁱ	P16671
PaxDbⁱ	P16671
PeptideAtlasⁱ	P16671
PRIDEⁱ	P16671
ProteomicsDBⁱ	15177 15178 53392 [P16671-1]

Protocols and materials databases

Antibodypediaⁱ	659, 1708 antibodies
The DNASU plasmid repository More...DNASUⁱ	948

Genome annotation databases

Ensemblⁱ	ENST00000309881; ENSP00000308165; ENSG00000135218 [P16671-1] ENST00000394788; ENSP00000378268; ENSG00000135218 [P16671-1] ENST00000432207; ENSP00000411411; ENSG00000135218 [P16671-1] ENST00000433696; ENSP00000401863; ENSG00000135218 [P16671-3] ENST00000435819; ENSP00000399421; ENSG00000135218 [P16671-1] ENST00000447544; ENSP00000415743; ENSG00000135218 [P16671-1] ENST00000538969; ENSP00000439543; ENSG00000135218 [P16671-4] ENST00000544133; ENSP00000441956; ENSG00000135218 [P16671-2]
GeneIDⁱ	948
KEGGⁱ	hsa:948
UCSCⁱ	uc003uhc.4, human [P16671-1]

Organism-specific databases

CTDⁱ	948
DisGeNETⁱ	948
GeneCardsⁱ	CD36
HGNCⁱ	HGNC:1663, CD36
HPAⁱ	ENSG00000135218, Tissue enhanced (adipose tissue, breast)
MalaCardsⁱ	CD36
MIMⁱ	173510, gene 248310, phenotype 608404, phenotype 610938, phenotype 611162, phenotype
neXtProtⁱ	NX_P16671
OpenTargetsⁱ	ENSG00000135218
PharmGKBⁱ	PA26212
VEuPathDBⁱ	HostDB:ENSG00000135218.17
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3776, Eukaryota
GeneTreeⁱ	ENSGT00940000153372
HOGENOMⁱ	CLU_019853_0_0_1
InParanoidⁱ	P16671
OMAⁱ	MIAYCVC
OrthoDBⁱ	1106566at2759
PhylomeDBⁱ	P16671
TreeFamⁱ	TF317925

Enzyme and pathway databases

PathwayCommonsⁱ	P16671
Reactomeⁱ	R-HSA-114608, Platelet degranulation R-HSA-1236973, Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236974, ER-Phagosome pathway R-HSA-166058, MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-168188, Toll Like Receptor TLR6:TLR2 Cascade R-HSA-1989781, PPARA activates gene expression R-HSA-3000471, Scavenging by Class B Receptors R-HSA-381340, Transcriptional regulation of white adipocyte differentiation R-HSA-434313, Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-5602498, MyD88 deficiency (TLR2/4) R-HSA-5603041, IRAK4 deficiency (TLR2/4) R-HSA-5686938, Regulation of TLR by endogenous ligand R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-6798695, Neutrophil degranulation
SIGNORⁱ	P16671

Miscellaneous databases

BioGRID-ORCSⁱ	948, 5 hits in 987 CRISPR screens
ChiTaRSⁱ	CD36, human
GeneWikiⁱ	CD36
GenomeRNAiⁱ	948
Pharosⁱ	P16671, Tbio
Protein Ontology More...PROⁱ	PR:P16671
RNActⁱ	P16671, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000135218, Expressed in adipose tissue and 213 other tissues
ExpressionAtlasⁱ	P16671, baseline and differential
Genevisibleⁱ	P16671, HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR005428, CD36/SCARB1/SNMP1 IPR033076, CD36_chordates IPR002159, CD36_fam
PANTHERⁱ	PTHR11923, PTHR11923, 1 hit PTHR11923:SF12, PTHR11923:SF12, 1 hit
Pfamⁱ	View protein in Pfam PF01130, CD36, 1 hit
PRINTSⁱ	PR01610, CD36ANTIGEN PR01609, CD36FAMILY
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CD36_HUMAN
Accessionⁱ	P16671Primary (citable) accession number: P16671 Secondary accession number(s): D9IX66 Q9BZN5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
	Last sequence update:	January 23, 2007
	Last modified:	April 7, 2021
	This is version 220 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Direct protein sequencing, Reference proteome

Documents

Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniProtKB - P16671 (CD36_HUMAN)

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Platelet glycoprotein 4

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Keywords - Cellular componenti

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Keywords - Diseasei

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

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<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

P16671

GO - Molecular functioni

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<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

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<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

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Keywords - Coding sequence diversityi

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ