P0CX49 · RL18A_YEAST

Function

function

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.

Miscellaneous

There are 2 genes for eL18 in yeast.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentcytosolic large ribosomal subunit
Molecular FunctionRNA binding
Molecular Functionstructural constituent of ribosome
Biological Processcytoplasmic translation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Large ribosomal subunit protein eL18A
  • Alternative names
    • 60S ribosomal protein L18-A
    • RP28

Gene names

    • Name
      RPL18A
    • Synonyms
      RP28A
    • Ordered locus names
      YOL120C

Organism names

Accessions

  • Primary accession
    P0CX49
  • Secondary accessions
    • D6W0P3
    • P07279

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for initiator methionine, chain, modified residue (large scale data), modified residue, cross-link.

Type
IDPosition(s)Source
Description
Initiator methionine1UniProtRemoved
ChainPRO_00001327842-186UniProtLarge ribosomal subunit protein eL18A
Modified residue (large scale data)17PTMeXchangePhosphothreonine
Modified residue (large scale data)21PTMeXchangePhosphoserine
Modified residue (large scale data)25PTMeXchangePhosphotyrosine
Modified residue (large scale data)33PTMeXchangePhosphotyrosine
Modified residue (large scale data)34PTMeXchangePhosphothreonine
Modified residue (large scale data)40PTMeXchangePhosphothreonine
Modified residue50UniProtN6,N6,N6-trimethyllysine
Modified residue (large scale data)63PTMeXchangePhosphoserine
Modified residue (large scale data)65PTMeXchangePhosphoserine
Modified residue (large scale data)80PTMeXchangePhosphothreonine
Modified residue (large scale data)86PTMeXchangePhosphothreonine
Modified residue (large scale data)99PTMeXchangePhosphothreonine
Cross-link116UniProtGlycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Modified residue (large scale data)123PTMeXchangePhosphothreonine
Modified residue (large scale data)137PTMeXchangePhosphothreonine
Modified residue (large scale data)146PTMeXchangePhosphoserine
Modified residue (large scale data)167PTMeXchangePhosphoserine
Modified residue (large scale data)168PTMeXchangePhosphothreonine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:22096102, PubMed:9559554).
eL18 interacts with NAP1 (PubMed:18086883).

Protein-protein interaction databases

Miscellaneous

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    186
  • Mass (Da)
    20,563
  • Last updated
    2011-06-28 v1
  • MD5 Checksum
    86BA4201F345F1AA482612A305B80433
MGIDHTSKQHKRSGHRTAPKSDNVYLKLLVKLYTFLARRTDAPFNKVVLKALFLSKINRPPVSVSRIARALKQEGAANKTVVVVGTVTDDARIFEFPKTTVAALRFTAGARAKIVKAGGECITLDQLAVRAPKGQNTLILRGPRNSREAVRHFGMGPHKGKAPRILSTGRKFERARGRRRSKGFKV

Mass Spectrometry

Molecular mass is 20,419.432 Da. Determined by Electrospray. Monoisotopic mass.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X01099
EMBL· GenBank· DDBJ
CAA25573.1
EMBL· GenBank· DDBJ
Genomic DNA
X02635
EMBL· GenBank· DDBJ
CAA26481.1
EMBL· GenBank· DDBJ
Genomic DNA
X95258
EMBL· GenBank· DDBJ
CAA64550.1
EMBL· GenBank· DDBJ
Genomic DNA
Z74862
EMBL· GenBank· DDBJ
CAA99139.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006948
EMBL· GenBank· DDBJ
DAA10664.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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