P0C174 · KEX11_TITSE

Function

function

Potassium channel blocker. At 3 uM, this toxin blocks voltage-independently voltage-gated potassium channels rKv1.2/KCNA2 (25%), hKv1.3/KCNA3 (27%), rKv4.2/KCND2 (25%), Kv10.1/KCNH1/EAG1 (15%), Kv11/hERG (12%), and Shaker-IR (10%). On hKv1.3/KCNA3, the IC50 is 17.1 +-3.3 uM.

Miscellaneous

Negative results: does not block all sodium channels tested and several potassium channels. Does not block the following voltage-gated potassium channels: rKv1.1/KCNA1, rKv1.1/KCNA1, rKv1.5/KCNA5, rKv1.6/KCNA6, rKv2.1/KCNB1, hKv3.1/KCNC1, and Kv7.2/KCNQ2. Does not block the following voltage-gated sodium channels: rNav1.1/SCN1A, rNav1.4/SCN4A, hNav1.5/SCN5A, mNav1.6/SCN8A, and DmNav1/para.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Molecular Functionpotassium channel regulator activity
Molecular Functiontoxin activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Potassium channel toxin epsilon-KTx 1.1
  • Alternative names
    • Tityustoxin-11
      (Ts11
      )
    • TsPep1

Organism names

Accessions

  • Primary accession
    P0C174
  • Secondary accessions
    • A0A218QX37
    • A0A218QX98

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, peptide, disulfide bond, propeptide.

TypeIDPosition(s)Description
Signal1-30
PeptidePRO_000022781931-59Potassium channel toxin epsilon-KTx 1.1
Disulfide bond34↔42
Disulfide bond37↔58
Disulfide bond41↔51
Disulfide bond46↔56
PropeptidePRO_000045573160-72

Keywords

Expression

Tissue specificity

Expressed by the venom gland.

Structure

3D structure databases

Miscellaneous

Family & Domains

Domain

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
Is completely devoid of the classical secondary structure elements (alpha-helix and/or beta-strand).

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    72
  • Mass (Da)
    7,721
  • Last updated
    2022-08-03 v2
  • Checksum
    11E25A587EF2FB0E
MKLSCGFLLILLVLSAMIATFSEVEAMKPSKPKCGLCRYRCCSGGCSSGKCVNGACDCSGRSDLNDELEKYQ

Sequence caution

The sequence JAW06973.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Mass Spectrometry

Molecular mass is 2,938.92 Da. Determined by MALDI.
Molecular mass is 2,938.2 Da. Determined by MALDI.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GEUW01000035
EMBL· GenBank· DDBJ
JAW07010.1
EMBL· GenBank· DDBJ
mRNA
GEUW01000072
EMBL· GenBank· DDBJ
JAW06973.1
EMBL· GenBank· DDBJ
mRNA Different initiation
MT450713
EMBL· GenBank· DDBJ
QPD99049.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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