P0A2W8 · ALR_STRPN
- ProteinAlanine racemase
- Genealr
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids367 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.
Catalytic activity
- L-alanine = D-alanine
Cofactor
Pathway
Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 40 | Proton acceptor; specific for D-alanine | ||||
Sequence: K | ||||||
Binding site | 136 | substrate | ||||
Sequence: R | ||||||
Active site | 263 | Proton acceptor; specific for L-alanine | ||||
Sequence: Y | ||||||
Binding site | 310 | substrate | ||||
Sequence: M |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | alanine racemase activity | |
Molecular Function | pyridoxal phosphate binding | |
Biological Process | D-alanine biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAlanine racemase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Streptococcaceae > Streptococcus
Accessions
- Primary accessionP0A2W8
- Secondary accessions
Proteomes
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000114581 | 1-367 | Alanine racemase | |||
Sequence: MKASPHRPTKALIHLGAIRQNIQQMGAHIPQGTLKLAVVKANAYGHGAVAVAKAIQDDVDGFCVSNIDEAIELRQAGLSKPILILGVSEIEAVALAKEYDFTLTVAGLEWIQALLDKEVDLTGLTVHLKIDSGMGRIGFREASEVEQAQDLLQQHGVCVEGIFTHFATADEESDDYFNAQLERFKTILASMKEVPELVHASNSATTLWHVETIFNAVRMGDAMYGLNPSGAVLDLPYDLIPALTLESALVHVKTVPAGACMGYGATYQADSEQVIATVPIGYADGWTRDMQNFSVLVDGQACPIVGRVSMDQITIRLPKLYPLGTKVTLIGSNGDKEITATQVATYRVTINYEVVCLLSDRIPREYY | ||||||
Modified residue | 40 | N6-(pyridoxal phosphate)lysine | ||||
Sequence: K | ||||||
Modified residue | 129 | N6-carboxylysine | ||||
Sequence: K |
Proteomic databases
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length367
- Mass (Da)39,858
- Last updated2005-03-15 v1
- ChecksumA79E2F1B439B18B7
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 354 | in Ref. 3; CAA90279 | ||||
Sequence: V → E |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF171873 EMBL· GenBank· DDBJ | AAD51027.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE005672 EMBL· GenBank· DDBJ | AAK75776.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z49988 EMBL· GenBank· DDBJ | CAA90279.1 EMBL· GenBank· DDBJ | Genomic DNA |