P05740 · RL17A_YEAST

Function

function

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.

Miscellaneous

There are 2 genes for uL22 in yeast.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentcytosolic large ribosomal subunit
Cellular Componentpreribosome, large subunit precursor
Molecular Functionstructural constituent of ribosome
Biological Processcleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Processcytoplasmic translation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Large ribosomal subunit protein uL22A
  • Alternative names
    • 60S ribosomal protein L17-A
    • L20A
    • YL17

Gene names

    • Name
      RPL17A
    • Synonyms
      RPL17, RPL20A
    • Ordered locus names
      YKL180W

Organism names

Accessions

  • Primary accession
    P05740
  • Secondary accessions
    • D6VX21

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for initiator methionine, chain, modified residue (large scale data), cross-link, modified residue.

Type
IDPosition(s)Source
Description
Initiator methionine1UniProtRemoved
ChainPRO_00001253472-184UniProtLarge ribosomal subunit protein uL22A
Modified residue (large scale data)7PTMeXchangePhosphothreonine
Modified residue (large scale data)8PTMeXchangePhosphoserine
Modified residue (large scale data)9PTMeXchangePhosphothreonine
Modified residue (large scale data)16PTMeXchangePhosphoserine
Modified residue (large scale data)20PTMeXchangePhosphoserine
Modified residue (large scale data)25PTMeXchangePhosphoserine
Modified residue (large scale data)29PTMeXchangePhosphothreonine
Modified residue (large scale data)32PTMeXchangePhosphothreonine
Modified residue (large scale data)42PTMeXchangePhosphothreonine
Cross-link46UniProtGlycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Modified residue (large scale data)47PTMeXchangePhosphotyrosine
Modified residue (large scale data)65PTMeXchangePhosphoserine
Modified residue (large scale data)66PTMeXchangePhosphoserine
Modified residue70UniProtPhosphothreonine
Modified residue (large scale data)70PTMeXchangePhosphothreonine
Modified residue (large scale data)110PTMeXchangePhosphothreonine
Modified residue (large scale data)113PTMeXchangePhosphotyrosine
Modified residue (large scale data)115PTMeXchangePhosphoserine
Modified residue (large scale data)141PTMeXchangePhosphoserine
Modified residue (large scale data)142PTMeXchangePhosphoserine
Modified residue (large scale data)144PTMeXchangePhosphoserine
Modified residue (large scale data)151PTMeXchangePhosphothreonine

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). uL22 is associated with the polypeptide exit tunnel (PubMed:22096102, PubMed:9559554).

Protein-protein interaction databases

Miscellaneous

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    184
  • Mass (Da)
    20,549
  • Last updated
    2007-01-23 v4
  • MD5 Checksum
    202CCA977C8C1ADA38A31AD0884399E0
MARYGATSTNPAKSASARGSYLRVSFKNTRETAQAINGWELTKAQKYLEQVLDHQRAIPFRRFNSSIGRTAQGKEFGVTKARWPAKSVKFVQGLLQNAAANAEAKGLDATKLYVSHIQVNQAPKQRRRTYRAHGRINKYESSPSHIELVVTEKEEAVAKAAEKKVVRLTSRQRGRIAAQKRIAA

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict104-114in Ref. 3; CAA52258

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Z28180
EMBL· GenBank· DDBJ
CAA82023.1
EMBL· GenBank· DDBJ
Genomic DNA
Z28179
EMBL· GenBank· DDBJ
CAA82022.1
EMBL· GenBank· DDBJ
Genomic DNA
X74151
EMBL· GenBank· DDBJ
CAA52258.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006944
EMBL· GenBank· DDBJ
DAA08987.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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