P04467 · CALB1_BOVIN

  • Protein
    Calbindin
  • Gene
    CALB1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Buffers cytosolic calcium. May stimulate a membrane Ca2+-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.

Features

Showing features for binding site.

126120406080100120140160180200220240260
TypeIDPosition(s)Description
Binding site24Ca2+ 1 (UniProtKB | ChEBI)
Binding site26Ca2+ 1 (UniProtKB | ChEBI)
Binding site28Ca2+ 1 (UniProtKB | ChEBI)
Binding site30Ca2+ 1 (UniProtKB | ChEBI)
Binding site35Ca2+ 1 (UniProtKB | ChEBI)
Binding site111Ca2+ 2 (UniProtKB | ChEBI)
Binding site113Ca2+ 2 (UniProtKB | ChEBI)
Binding site115Ca2+ 2 (UniProtKB | ChEBI)
Binding site122Ca2+ 2 (UniProtKB | ChEBI)
Binding site155Ca2+ 3 (UniProtKB | ChEBI)
Binding site157Ca2+ 3 (UniProtKB | ChEBI)
Binding site159Ca2+ 3 (UniProtKB | ChEBI)
Binding site161Ca2+ 3 (UniProtKB | ChEBI)
Binding site166Ca2+ 3 (UniProtKB | ChEBI)
Binding site199Ca2+ 4 (UniProtKB | ChEBI)
Binding site201Ca2+ 4 (UniProtKB | ChEBI)
Binding site203Ca2+ 4 (UniProtKB | ChEBI)
Binding site205Ca2+ 4 (UniProtKB | ChEBI)
Binding site210Ca2+ 4 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentdendrite
Cellular Componentdendritic spine
Cellular Componentnucleus
Cellular Componentsynapse
Cellular Componentterminal bouton
Molecular Functioncalcium ion binding
Molecular Functionvitamin D binding
Biological Processregulation of long-term synaptic potentiation
Biological Processregulation of presynaptic cytosolic calcium ion concentration

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Calbindin
  • Alternative names
    • Calbindin D28
    • D-28K
    • Vitamin D-dependent calcium-binding protein, avian-type

Gene names

    • Name
      CALB1

Organism names

  • Taxonomic identifier
  • Strain
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    P04467
  • Secondary accessions
    • Q1LZA2

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
Modified residue2N-acetylalanine
ChainPRO_00000734712-261Calbindin

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with RANBP9.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region2-7Interaction with RANBP9
Domain11-46EF-hand 1
Domain53-88EF-hand 2
Domain98-133EF-hand 3
Domain142-177EF-hand 4
Domain186-221EF-hand 5
Domain226-251EF-hand 6

Domain

This protein has four functional calcium-binding sites; potential sites II and VI have lost affinity for calcium.

Sequence similarities

Belongs to the calbindin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    261
  • Mass (Da)
    29,964
  • Last updated
    2007-01-23 v3
  • Checksum
    847CD14BD7431E03
MAESHLQSSLITASQFFEIWLHFDADGSGYLEGKELQNLIQELQQARKKAGLELSPEMKTFVDQYGQRDDGKIGIVELAHVLPTEENFLLLFRCQQLKSCEEFMKTWRKYDTDHSGFIETEELKNFLKDLLEKANKTVDDTKLAEYTDLMLKLFDSNNDGKLELTEMARLLPVQENFLLKFQGVKMCGKEFNKAFELYDQDGNGYIDENELDALLKDLCEKNKQDLDINNIPTYKKSIMALSDGGKLYRTDLALILSAGDN

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A3Q1LUQ4A0A3Q1LUQ4_BOVINCALB1236
A0A3Q1LWK7A0A3Q1LWK7_BOVINCALB1243

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict67in Ref. 2; AA sequence
Sequence conflict203in Ref. 2; AA sequence

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC116125
EMBL· GenBank· DDBJ
AAI16126.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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