P00962 · SYQ_ECOLI
- ProteinGlutamine--tRNA ligase
- GeneglnS
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids554 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
Catalytic activity
- tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 35-37 | ATP (UniProtKB | ChEBI) | |||
Binding site | 41-47 | ATP (UniProtKB | ChEBI) | |||
Binding site | 67 | L-glutamine (UniProtKB | ChEBI) | |||
Binding site | 212 | L-glutamine (UniProtKB | ChEBI) | |||
Binding site | 231 | ATP (UniProtKB | ChEBI) | |||
Binding site | 261-262 | ATP (UniProtKB | ChEBI) | |||
Binding site | 269-271 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | glutamine-tRNA ligase activity | |
Biological Process | glutaminyl-tRNA aminoacylation | |
Biological Process | glutamyl-tRNA aminoacylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlutamine--tRNA ligase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia
Accessions
- Primary accessionP00962
- Secondary accessions
Proteomes
Subcellular Location
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Mutagenesis | 31 | Decreased affinity for glutamine and catalytic activity. | |||
Mutagenesis | 230 | Decreases catalytic activity 1000-fold, but has no effect on affinity for glutamine. Loss of catalytic activity; when associated with I-256. | |||
Mutagenesis | 256 | Loss of catalytic activity; when associated with R-230. | |||
Chemistry
Structure
Family & Domains
Features
Showing features for motif, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Motif | 34-44 | 'HIGH' region | |||
Motif | 268-272 | 'KMSKS' region | |||
Region | 317-324 | Interaction with tRNA | |||
Sequence similarities
Belongs to the class-I aminoacyl-tRNA synthetase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length554
- Mass (Da)63,478
- Last updated2007-01-23 v3
- MD5 ChecksumFDE8F8B6CC11B1C3EE29BAF3AAC96D3E
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
V01575 EMBL· GenBank· DDBJ | CAA24894.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U00096 EMBL· GenBank· DDBJ | AAC73774.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP009048 EMBL· GenBank· DDBJ | BAA35328.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AH003126 EMBL· GenBank· DDBJ | AAA69006.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
M16368 EMBL· GenBank· DDBJ | AAA69006.2 EMBL· GenBank· DDBJ | Genomic DNA |