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Entry version 146 (16 Oct 2019)
Sequence version 2 (01 Aug 1998)
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Protein

Mycocerosic acid synthase-like polyketide synthase

Gene

pks5

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Polyketide synthase likely involved in the biosynthesis of a polymethyl-branched fatty acid (PMB-FA) that might only be produced during host infection. Is required for the full virulence of M.tuberculosis during host infection.Curated1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei185Acyl-thioester intermediate; for beta-ketoacyl synthase activityPROSITE-ProRule annotation1
Active sitei634Acyl-ester intermediate; for acyltransferase activityBy similarity1
Active sitei938Proton acceptor; for dehydratase activityBy similarity1
Active sitei1108Proton donor; for dehydratase activityBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1773 – 1776NADPBy similarity4
Nucleotide bindingi1796 – 1799NADPBy similarity4
Nucleotide bindingi1824 – 1825NADPBy similarity2
Nucleotide bindingi1897 – 1898NADPBy similarity2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Multifunctional enzyme, Oxidoreductase, Transferase
Biological processFatty acid metabolism, Lipid metabolism, Virulence
LigandNADP

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MTBH37RV:G185E-5715-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MTU-9635470 Dimycocersyl phthiocerol biosynthesis

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00094

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mycocerosic acid synthase-like polyketide synthase1 Publication (EC:2.3.1.-By similarity)
Short name:
MAS-like PKS1 Publication
Alternative name(s):
Polyketide synthase Pks5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pks51 PublicationImported
Ordered Locus Names:Rv1527cImported, LH57_08370Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83332 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001584 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

Organism-specific databases

Mycobacterium tuberculosis strain H37Rv genome database

More...
TubercuListi
Rv1527c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Disruption of this gene causes no major change in the fatty acid and lipid contents of the mutant strain in vitro; the mutant produces all the major methyl-branched fatty acid containing lipids, including DIM, in similar amounts to the wild-type strain. The replication of this mutant is unaffected in mouse bone-marrow macrophages. However, the mutant strain displays severe growth defects in mice, since it multiplies much less extensively than does the parental strain during the acute phase of infection in the lungs and spleen of mice infected via the respiratory route.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23PROSITE-ProRule annotationAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000043707824 – 2108Mycocerosic acid synthase-like polyketide synthaseAdd BLAST2085

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi24N-palmitoyl cysteinePROSITE-ProRule annotation1
Lipidationi24S-diacylglycerol cysteinePROSITE-ProRule annotation1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2060O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Lipoprotein, Palmitate, Phosphopantetheine, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O53901

PRoteomics IDEntifications database

More...
PRIDEi
O53901

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Is expressed in bacteria grown axenically (7H9 medium) and inside macrophages.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
83332.Rv1527c

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O53901

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2025 – 2101CarrierPROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni14 – 437Beta-ketoacyl synthase (KS)By similarityAdd BLAST424
Regioni438 – 542Linker domain (LD)By similarityAdd BLAST105
Regioni543 – 842Acyltransferase (AT)By similarityAdd BLAST300
Regioni900 – 1184Dehydratase (DH)By similarityAdd BLAST285
Regioni1220 – 1391Pseudo beta-ketoacyl reductase (PsiKR)By similarityAdd BLAST172
Regioni1419 – 1743Enoylreductase (ER)By similarityAdd BLAST325
Regioni1765 – 2004Beta-ketoacyl reductase (KR)By similarityAdd BLAST240

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Is organized in a condensing KS-AT and a modifying DH-PsiKR-ER-KR region, followed by a flexibly tethered ACP domain.By similarity

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG3321 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000046292

KEGG Orthology (KO)

More...
KOi
K12433

Identification of Orthologs from Complete Genome Data

More...
OMAi
MSDNMVI

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O53901

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 1 hit
3.10.129.110, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001227 Ac_transferase_dom_sf
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR013149 ADH_C
IPR013154 ADH_N
IPR011032 GroES-like_sf
IPR032821 KAsynt_C_assoc
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR016036 Malonyl_transacylase_ACP-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020801 PKS_acyl_transferase
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR020807 PKS_dehydratase
IPR042104 PKS_dehydratase_sf
IPR020843 PKS_ER
IPR013968 PKS_KR
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR016039 Thiolase-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00698 Acyl_transf_1, 1 hit
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
PF16197 KAsynt_C_assoc, 1 hit
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PF08659 KR, 1 hit
PF00550 PP-binding, 1 hit
PF14765 PS-DH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00827 PKS_AT, 1 hit
SM00826 PKS_DH, 1 hit
SM00829 PKS_ER, 1 hit
SM00825 PKS_KS, 1 hit
SM00823 PKS_PP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336 SSF47336, 1 hit
SSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 3 hits
SSF52151 SSF52151, 1 hit
SSF53901 SSF53901, 1 hit
SSF55048 SSF55048, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00606 B_KETOACYL_SYNTHASE, 1 hit
PS50075 CARRIER, 1 hit
PS51257 PROKAR_LIPOPROTEIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

O53901-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKERTKTVD RTRVTPVAVI GMGCRLPGGI DSPDRLWEAL LRGDDLVTEI
60 70 80 90 100
PADRWDIDEY YDPEPGVPGR TDCKWGAYLD NVGDFDPEFF GIGEKEAIAI
110 120 130 140 150
DPQHRLLLET SWEAMEHGGL TPNQMASRTG VFVGLVHTDY ILVHADNQTF
160 170 180 190 200
EGPYGNTGTN ACFASGRVAY AMGLQGPAIT VDTACSSGLT AIHLACRSLH
210 220 230 240 250
DGESDIALAG GVYVMLEPRR FASGSALGML SATGRCHAFD VSADGFVSGE
260 270 280 290 300
GCVMLALKRL PDALADGDRI LAVIRGTAAN QDGHTVNIAT PSRSAQVAAY
310 320 330 340 350
REALDVAGVD PATVGMVEAH GPGTPVGDPI EYASLAEVYG NDGPCALASV
360 370 380 390 400
KTNFGHTQSA AGALGLMKAV LALQHGVVPQ NLHFTALPDK LAAIETNLFV
410 420 430 440 450
PQEITPWPGA DQETPRRAAV SSYGMTGTNV HAIVEQAPVP APESGAPGDT
460 470 480 490 500
PATPGIDGAL LFALSASSQD ALRQTAARLA DWVDAQGPEL APADLAYTLA
510 520 530 540 550
RRRGHRPVRT AVLAATTAEL TEALREVATG EPPYPPAVGQ DDRGPVWVFS
560 570 580 590 600
GQGSQWAGMG ADLLATEPVF AATIAAIEPL IAAESGFSVT EAMTAPEVVT
610 620 630 640 650
GIDRVQPTLF AMQVALAATM KSYGVAPGAV IGHSLGESAA AVVAGALCLE
660 670 680 690 700
DGVRVICRRS ALMTRIAGAG AMASVELPAQ QVLSELMARG VNDAVVAVVA
710 720 730 740 750
SPQSTVIGGA TQTVRDLVAA WEQRDVLARE VAVDVASHSP QVDPILDELA
760 770 780 790 800
EALAEISPLQ PEIPYYSATS FDPREEPYCD AYYWVDNLRH TVRFAAAVQA
810 820 830 840 850
ALEDGYRVFT ELTPHPLLTH AVDQTARSLD MSAAALAGMR REQPLPHGLR
860 870 880 890 900
ALAGDLYAAG AAVDFAVLYP TGRLINAPLP TWNHRRLLLD DTTRRIAHAN
910 920 930 940 950
TVAVHPLLGS HVRLPEEPER HVWQGEVGTV TQPWLADHQI HGAAALPGAA
960 970 980 990 1000
YCEMALAAAR AVLGEASEVR DIRFEQMLLL DDETPIGVTA TVEAPGVVPL
1010 1020 1030 1040 1050
TVETSHDGRY TRQLAAVLHV VREADDAPDQ PPQKNIAELL ASHPHKVDGA
1060 1070 1080 1090 1100
EVRQWLDKRG HRLGPAFAGL VDAYIAEGAG DTVLAEVNLP GPLRSQVKAY
1110 1120 1130 1140 1150
GVHPVLLDAC FQSVAAHPAV QGMADGGLLL PLGVRRLRSY GSARHARYCC
1160 1170 1180 1190 1200
TTVTACGVGV EADLDVLDEH GAVVLAVRGL QLGTGASQAS ERARVLGERL
1210 1220 1230 1240 1250
LSIEWHEREL PENSHAEPGA WLLISTCDAT DLVAAQLTDA LKVHDAQCTT
1260 1270 1280 1290 1300
MSWPQRADHA AQAARLRDQL GTGGFTGVFV LTAPQTGDPD AESPVRGGEL
1310 1320 1330 1340 1350
VKHVVRIARE IPEITAQEPR LYVLTHNAQA VLSGDRPNLE QGGMRGLLRV
1360 1370 1380 1390 1400
IGAEHPHLKA SYVDVDEQTG AESVARQLLA ASGEDETAWR NDQWYTARLC
1410 1420 1430 1440 1450
PAPLRPEERQ TTVVDHAEAG MRLQIRTPGD LQTLEFAAFD RVPPGPGEIE
1460 1470 1480 1490 1500
VAVTASSINF ADVLVTFGRY QTLDGRQPQL GTDFAGVVSA VGPGVSELKV
1510 1520 1530 1540 1550
GDRVGGMSPN GCWATFVTCD ARLATRLPEG LTDAQAAAVT TASATAWYGL
1560 1570 1580 1590 1600
QDLARIKAGD KVLIHSATGG VGQAAIAIAR AAGAQIYATA GNEKRRDLLR
1610 1620 1630 1640 1650
DMGIEHVYDS RSVEFAEQIR RDTAGYGVDI VLNSVTGAAQ LAGLKLLALG
1660 1670 1680 1690 1700
GRFIEIGKRD IYSNTRLELL PFRRNLAFYG LDLGLMSVSH PAAVRELLST
1710 1720 1730 1740 1750
VYRLTVEGVL PMPQSTHYPL AEAATAIRVM GAAEHTGKLI LDVPHAGRSS
1760 1770 1780 1790 1800
VVLPPEQARV FRSDGSYIIT GGLGGLGLFL AEKMANAGAG RIVLSSRSQP
1810 1820 1830 1840 1850
SQKALETIEL VRAIGSDVVV ECGDIAQPDT ADRLVTAATA TGLPLRGVLH
1860 1870 1880 1890 1900
AAAVVEDATL ANITDELIER DWAPKAYGAW QLHRATADQP LDWFCSFSSA
1910 1920 1930 1940 1950
AALVGSPGQG AYAAANSWLD TFTHWRRAQD LPATSIAWGA WGQIGRAIAF
1960 1970 1980 1990 2000
AEQTGDAIAP EEGAYAFETL LRHNRAYSGY APVIGSPWLT AFAQHSPFAE
2010 2020 2030 2040 2050
KFQSLGQNRS GTSKFLAELV DLPREEWPDR LRRLLSKQVG LILRRTIDTD
2060 2070 2080 2090 2100
RLLSEYGLDS LSSQELRARV EAETGIRISA TEINTTVRGL ADLMCDKLAA

DRDAPAPA
Length:2,108
Mass (Da):223,889
Last modified:August 1, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1E3223687968A103
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP44291.1
CP009480 Genomic DNA Translation: AIR14281.1

NCBI Reference Sequences

More...
RefSeqi
NP_216043.1, NC_000962.3
WP_003913253.1, NZ_NVQJ01000004.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AIR14281; AIR14281; LH57_08370
CCP44291; CCP44291; Rv1527c

Database of genes from NCBI RefSeq genomes

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GeneIDi
886442

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mtu:Rv1527c
mtv:RVBD_1527c

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|83332.111.peg.1704

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP44291.1
CP009480 Genomic DNA Translation: AIR14281.1
RefSeqiNP_216043.1, NC_000962.3
WP_003913253.1, NZ_NVQJ01000004.1

3D structure databases

SMRiO53901
ModBaseiSearch...

Protein-protein interaction databases

STRINGi83332.Rv1527c

Proteomic databases

PaxDbiO53901
PRIDEiO53901

Genome annotation databases

EnsemblBacteriaiAIR14281; AIR14281; LH57_08370
CCP44291; CCP44291; Rv1527c
GeneIDi886442
KEGGimtu:Rv1527c
mtv:RVBD_1527c
PATRICifig|83332.111.peg.1704

Organism-specific databases

TubercuListiRv1527c

Phylogenomic databases

eggNOGiCOG3321 LUCA
HOGENOMiHOG000046292
KOiK12433
OMAiMSDNMVI
PhylomeDBiO53901

Enzyme and pathway databases

UniPathwayiUPA00094
BioCyciMTBH37RV:G185E-5715-MONOMER
ReactomeiR-MTU-9635470 Dimycocersyl phthiocerol biosynthesis

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
3.10.129.110, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit
InterProiView protein in InterPro
IPR001227 Ac_transferase_dom_sf
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR013149 ADH_C
IPR013154 ADH_N
IPR011032 GroES-like_sf
IPR032821 KAsynt_C_assoc
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR016036 Malonyl_transacylase_ACP-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020801 PKS_acyl_transferase
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR020807 PKS_dehydratase
IPR042104 PKS_dehydratase_sf
IPR020843 PKS_ER
IPR013968 PKS_KR
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF00698 Acyl_transf_1, 1 hit
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
PF16197 KAsynt_C_assoc, 1 hit
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PF08659 KR, 1 hit
PF00550 PP-binding, 1 hit
PF14765 PS-DH, 1 hit
SMARTiView protein in SMART
SM00827 PKS_AT, 1 hit
SM00826 PKS_DH, 1 hit
SM00829 PKS_ER, 1 hit
SM00825 PKS_KS, 1 hit
SM00823 PKS_PP, 1 hit
SUPFAMiSSF47336 SSF47336, 1 hit
SSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 3 hits
SSF52151 SSF52151, 1 hit
SSF53901 SSF53901, 1 hit
SSF55048 SSF55048, 1 hit
PROSITEiView protein in PROSITE
PS00606 B_KETOACYL_SYNTHASE, 1 hit
PS50075 CARRIER, 1 hit
PS51257 PROKAR_LIPOPROTEIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPKS5_MYCTU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O53901
Secondary accession number(s): F2GEH5, I6XBP9, L0T6X5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 7, 2016
Last sequence update: August 1, 1998
Last modified: October 16, 2019
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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