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UniProtKB - O53901 (PKS5_MYCTU)

Entry version 146 (16 Oct 2019)
Sequence version 2 (01 Aug 1998)
Previous versions | rss
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Protein

Mycocerosic acid synthase-like polyketide synthase

Gene

pks5

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Polyketide synthase likely involved in the biosynthesis of a polymethyl-branched fatty acid (PMB-FA) that might only be produced during host infection. Is required for the full virulence of M.tuberculosis during host infection.Curated1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei185Acyl-thioester intermediate; for beta-ketoacyl synthase activityPROSITE-ProRule annotation1
Active sitei634Acyl-ester intermediate; for acyltransferase activityBy similarity1
Active sitei938Proton acceptor; for dehydratase activityBy similarity1
Active sitei1108Proton donor; for dehydratase activityBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1773 – 1776NADPBy similarity4
Nucleotide bindingi1796 – 1799NADPBy similarity4
Nucleotide bindingi1824 – 1825NADPBy similarity2
Nucleotide bindingi1897 – 1898NADPBy similarity2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Multifunctional enzyme, Oxidoreductase, Transferase
Biological processFatty acid metabolism, Lipid metabolism, Virulence
LigandNADP

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MTBH37RV:G185E-5715-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MTU-9635470 Dimycocersyl phthiocerol biosynthesis

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00094

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mycocerosic acid synthase-like polyketide synthase1 Publication (EC:2.3.1.-By similarity)
Short name:
MAS-like PKS1 Publication
Alternative name(s):
Polyketide synthase Pks5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pks51 PublicationImported
Ordered Locus Names:Rv1527cImported, LH57_08370Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83332 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001584 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

Organism-specific databases

Mycobacterium tuberculosis strain H37Rv genome database

More...TubercuListi		Rv1527c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Disruption of this gene causes no major change in the fatty acid and lipid contents of the mutant strain in vitro; the mutant produces all the major methyl-branched fatty acid containing lipids, including DIM, in similar amounts to the wild-type strain. The replication of this mutant is unaffected in mouse bone-marrow macrophages. However, the mutant strain displays severe growth defects in mice, since it multiplies much less extensively than does the parental strain during the acute phase of infection in the lungs and spleen of mice infected via the respiratory route.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23PROSITE-ProRule annotationAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000043707824 – 2108Mycocerosic acid synthase-like polyketide synthaseAdd BLAST2085

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi24N-palmitoyl cysteinePROSITE-ProRule annotation1
Lipidationi24S-diacylglycerol cysteinePROSITE-ProRule annotation1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2060O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Lipoprotein, Palmitate, Phosphopantetheine, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O53901

PRoteomics IDEntifications database

More...PRIDEi		O53901

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Is expressed in bacteria grown axenically (7H9 medium) and inside macrophages.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		83332.Rv1527c

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O53901

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2025 – 2101CarrierPROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni14 – 437Beta-ketoacyl synthase (KS)By similarityAdd BLAST424
Regioni438 – 542Linker domain (LD)By similarityAdd BLAST105
Regioni543 – 842Acyltransferase (AT)By similarityAdd BLAST300
Regioni900 – 1184Dehydratase (DH)By similarityAdd BLAST285
Regioni1220 – 1391Pseudo beta-ketoacyl reductase (PsiKR)By similarityAdd BLAST172
Regioni1419 – 1743Enoylreductase (ER)By similarityAdd BLAST325
Regioni1765 – 2004Beta-ketoacyl reductase (KR)By similarityAdd BLAST240

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Is organized in a condensing KS-AT and a modifying DH-PsiKR-ER-KR region, followed by a flexibly tethered ACP domain.By similarity

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG3321 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000046292

KEGG Orthology (KO)

More...KOi		K12433

Identification of Orthologs from Complete Genome Data

More...OMAi		MSDNMVI

Database for complete collections of gene phylogenies

More...PhylomeDBi		O53901

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1200.10, 1 hit
3.10.129.110, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001227 Ac_transferase_dom_sf
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR013149 ADH_C
IPR013154 ADH_N
IPR011032 GroES-like_sf
IPR032821 KAsynt_C_assoc
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR016036 Malonyl_transacylase_ACP-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020801 PKS_acyl_transferase
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR020807 PKS_dehydratase
IPR042104 PKS_dehydratase_sf
IPR020843 PKS_ER
IPR013968 PKS_KR
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR016039 Thiolase-like

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00698 Acyl_transf_1, 1 hit
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
PF16197 KAsynt_C_assoc, 1 hit
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PF08659 KR, 1 hit
PF00550 PP-binding, 1 hit
PF14765 PS-DH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00827 PKS_AT, 1 hit
SM00826 PKS_DH, 1 hit
SM00829 PKS_ER, 1 hit
SM00825 PKS_KS, 1 hit
SM00823 PKS_PP, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47336 SSF47336, 1 hit
SSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 3 hits
SSF52151 SSF52151, 1 hit
SSF53901 SSF53901, 1 hit
SSF55048 SSF55048, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00606 B_KETOACYL_SYNTHASE, 1 hit
PS50075 CARRIER, 1 hit
PS51257 PROKAR_LIPOPROTEIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

O53901-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKERTKTVD RTRVTPVAVI GMGCRLPGGI DSPDRLWEAL LRGDDLVTEI 
        60         70         80         90        100
PADRWDIDEY YDPEPGVPGR TDCKWGAYLD NVGDFDPEFF GIGEKEAIAI 
       110        120        130        140        150
DPQHRLLLET SWEAMEHGGL TPNQMASRTG VFVGLVHTDY ILVHADNQTF 
       160        170        180        190        200
EGPYGNTGTN ACFASGRVAY AMGLQGPAIT VDTACSSGLT AIHLACRSLH 
       210        220        230        240        250
DGESDIALAG GVYVMLEPRR FASGSALGML SATGRCHAFD VSADGFVSGE 
       260        270        280        290        300
GCVMLALKRL PDALADGDRI LAVIRGTAAN QDGHTVNIAT PSRSAQVAAY 
       310        320        330        340        350
REALDVAGVD PATVGMVEAH GPGTPVGDPI EYASLAEVYG NDGPCALASV 
       360        370        380        390        400
KTNFGHTQSA AGALGLMKAV LALQHGVVPQ NLHFTALPDK LAAIETNLFV 
       410        420        430        440        450
PQEITPWPGA DQETPRRAAV SSYGMTGTNV HAIVEQAPVP APESGAPGDT 
       460        470        480        490        500
PATPGIDGAL LFALSASSQD ALRQTAARLA DWVDAQGPEL APADLAYTLA 
       510        520        530        540        550
RRRGHRPVRT AVLAATTAEL TEALREVATG EPPYPPAVGQ DDRGPVWVFS 
       560        570        580        590        600
GQGSQWAGMG ADLLATEPVF AATIAAIEPL IAAESGFSVT EAMTAPEVVT 
       610        620        630        640        650
GIDRVQPTLF AMQVALAATM KSYGVAPGAV IGHSLGESAA AVVAGALCLE 
       660        670        680        690        700
DGVRVICRRS ALMTRIAGAG AMASVELPAQ QVLSELMARG VNDAVVAVVA 
       710        720        730        740        750
SPQSTVIGGA TQTVRDLVAA WEQRDVLARE VAVDVASHSP QVDPILDELA 
       760        770        780        790        800
EALAEISPLQ PEIPYYSATS FDPREEPYCD AYYWVDNLRH TVRFAAAVQA 
       810        820        830        840        850
ALEDGYRVFT ELTPHPLLTH AVDQTARSLD MSAAALAGMR REQPLPHGLR 
       860        870        880        890        900
ALAGDLYAAG AAVDFAVLYP TGRLINAPLP TWNHRRLLLD DTTRRIAHAN 
       910        920        930        940        950
TVAVHPLLGS HVRLPEEPER HVWQGEVGTV TQPWLADHQI HGAAALPGAA 
       960        970        980        990       1000
YCEMALAAAR AVLGEASEVR DIRFEQMLLL DDETPIGVTA TVEAPGVVPL 
      1010       1020       1030       1040       1050
TVETSHDGRY TRQLAAVLHV VREADDAPDQ PPQKNIAELL ASHPHKVDGA 
      1060       1070       1080       1090       1100
EVRQWLDKRG HRLGPAFAGL VDAYIAEGAG DTVLAEVNLP GPLRSQVKAY 
      1110       1120       1130       1140       1150
GVHPVLLDAC FQSVAAHPAV QGMADGGLLL PLGVRRLRSY GSARHARYCC 
      1160       1170       1180       1190       1200
TTVTACGVGV EADLDVLDEH GAVVLAVRGL QLGTGASQAS ERARVLGERL 
      1210       1220       1230       1240       1250
LSIEWHEREL PENSHAEPGA WLLISTCDAT DLVAAQLTDA LKVHDAQCTT 
      1260       1270       1280       1290       1300
MSWPQRADHA AQAARLRDQL GTGGFTGVFV LTAPQTGDPD AESPVRGGEL 
      1310       1320       1330       1340       1350
VKHVVRIARE IPEITAQEPR LYVLTHNAQA VLSGDRPNLE QGGMRGLLRV 
      1360       1370       1380       1390       1400
IGAEHPHLKA SYVDVDEQTG AESVARQLLA ASGEDETAWR NDQWYTARLC 
      1410       1420       1430       1440       1450
PAPLRPEERQ TTVVDHAEAG MRLQIRTPGD LQTLEFAAFD RVPPGPGEIE 
      1460       1470       1480       1490       1500
VAVTASSINF ADVLVTFGRY QTLDGRQPQL GTDFAGVVSA VGPGVSELKV 
      1510       1520       1530       1540       1550
GDRVGGMSPN GCWATFVTCD ARLATRLPEG LTDAQAAAVT TASATAWYGL 
      1560       1570       1580       1590       1600
QDLARIKAGD KVLIHSATGG VGQAAIAIAR AAGAQIYATA GNEKRRDLLR 
      1610       1620       1630       1640       1650
DMGIEHVYDS RSVEFAEQIR RDTAGYGVDI VLNSVTGAAQ LAGLKLLALG 
      1660       1670       1680       1690       1700
GRFIEIGKRD IYSNTRLELL PFRRNLAFYG LDLGLMSVSH PAAVRELLST 
      1710       1720       1730       1740       1750
VYRLTVEGVL PMPQSTHYPL AEAATAIRVM GAAEHTGKLI LDVPHAGRSS 
      1760       1770       1780       1790       1800
VVLPPEQARV FRSDGSYIIT GGLGGLGLFL AEKMANAGAG RIVLSSRSQP 
      1810       1820       1830       1840       1850
SQKALETIEL VRAIGSDVVV ECGDIAQPDT ADRLVTAATA TGLPLRGVLH 
      1860       1870       1880       1890       1900
AAAVVEDATL ANITDELIER DWAPKAYGAW QLHRATADQP LDWFCSFSSA 
      1910       1920       1930       1940       1950
AALVGSPGQG AYAAANSWLD TFTHWRRAQD LPATSIAWGA WGQIGRAIAF 
      1960       1970       1980       1990       2000
AEQTGDAIAP EEGAYAFETL LRHNRAYSGY APVIGSPWLT AFAQHSPFAE 
      2010       2020       2030       2040       2050
KFQSLGQNRS GTSKFLAELV DLPREEWPDR LRRLLSKQVG LILRRTIDTD 
      2060       2070       2080       2090       2100
RLLSEYGLDS LSSQELRARV EAETGIRISA TEINTTVRGL ADLMCDKLAA 

DRDAPAPA
Length:2,108
Mass (Da):223,889
Last modified:August 1, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1E3223687968A103
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP44291.1
CP009480 Genomic DNA Translation: AIR14281.1

NCBI Reference Sequences

More...RefSeqi		NP_216043.1, NC_000962.3
WP_003913253.1, NZ_NVQJ01000004.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AIR14281; AIR14281; LH57_08370
CCP44291; CCP44291; Rv1527c

Database of genes from NCBI RefSeq genomes

More...GeneIDi		886442

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mtu:Rv1527c
mtv:RVBD_1527c

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|83332.111.peg.1704

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP44291.1
CP009480 Genomic DNA Translation: AIR14281.1
RefSeqiNP_216043.1, NC_000962.3
WP_003913253.1, NZ_NVQJ01000004.1

3D structure databases

SMRiO53901
ModBaseiSearch...

Protein-protein interaction databases

STRINGi83332.Rv1527c

Proteomic databases

PaxDbiO53901
PRIDEiO53901

Genome annotation databases

EnsemblBacteriaiAIR14281; AIR14281; LH57_08370
CCP44291; CCP44291; Rv1527c
GeneIDi886442
KEGGimtu:Rv1527c
mtv:RVBD_1527c
PATRICifig|83332.111.peg.1704

Organism-specific databases

TubercuListiRv1527c

Phylogenomic databases

eggNOGiCOG3321 LUCA
HOGENOMiHOG000046292
KOiK12433
OMAiMSDNMVI
PhylomeDBiO53901

Enzyme and pathway databases

UniPathwayiUPA00094
BioCyciMTBH37RV:G185E-5715-MONOMER
ReactomeiR-MTU-9635470 Dimycocersyl phthiocerol biosynthesis

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
3.10.129.110, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit
InterProiView protein in InterPro
IPR001227 Ac_transferase_dom_sf
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR013149 ADH_C
IPR013154 ADH_N
IPR011032 GroES-like_sf
IPR032821 KAsynt_C_assoc
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR016036 Malonyl_transacylase_ACP-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020801 PKS_acyl_transferase
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR020807 PKS_dehydratase
IPR042104 PKS_dehydratase_sf
IPR020843 PKS_ER
IPR013968 PKS_KR
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF00698 Acyl_transf_1, 1 hit
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
PF16197 KAsynt_C_assoc, 1 hit
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PF08659 KR, 1 hit
PF00550 PP-binding, 1 hit
PF14765 PS-DH, 1 hit
SMARTiView protein in SMART
SM00827 PKS_AT, 1 hit
SM00826 PKS_DH, 1 hit
SM00829 PKS_ER, 1 hit
SM00825 PKS_KS, 1 hit
SM00823 PKS_PP, 1 hit
SUPFAMiSSF47336 SSF47336, 1 hit
SSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 3 hits
SSF52151 SSF52151, 1 hit
SSF53901 SSF53901, 1 hit
SSF55048 SSF55048, 1 hit
PROSITEiView protein in PROSITE
PS00606 B_KETOACYL_SYNTHASE, 1 hit
PS50075 CARRIER, 1 hit
PS51257 PROKAR_LIPOPROTEIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPKS5_MYCTU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O53901
Secondary accession number(s): F2GEH5, I6XBP9, L0T6X5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 7, 2016
Last sequence update: August 1, 1998
Last modified: October 16, 2019
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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