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Entry version 88 (16 Oct 2019)
Sequence version 1 (01 Jun 1998)
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Protein

Uncharacterized PE-PGRS family protein PE_PGRS54

Gene

PE_PGRS54

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MTBH37RV:G185E-7785-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized PE-PGRS family protein PE_PGRS54
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PE_PGRS54
Ordered Locus Names:Rv3508
ORF Names:MTV023.15
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83332 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001584 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

Organism-specific databases

Mycobacterium tuberculosis strain H37Rv genome database

More...
TubercuListi
Rv3508

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000235781 – 1901Uncharacterized PE-PGRS family protein PE_PGRS54Add BLAST1901

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O53553

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
83332.Rv3508

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O53553

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 93PESequence analysisAdd BLAST93

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the mycobacterial PE family. PGRS subfamily.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Repeat

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

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OMAi
NDSGTWV

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000084 PE-PGRS_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00934 PE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O53553-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFVLIAPEF VTAAAGDLTN LGSSISAANA SAASATTQVL AAGADEVSAR
60 70 80 90 100
IAALFGGFGL EYQAISAQVA AYHQRFVQAL STGAGAYASA EAAAAEQIVL
110 120 130 140 150
GVINAPTQAL LGRPLIGDGA NATTPGGAGG AGGLLFGNGG AGAAGAPGQA
160 170 180 190 200
GGPGGPAGLW GNGGPGGAGG SGGGTGGAGG AGGWLFGVGG AGGVGGAGGG
210 220 230 240 250
TGGAGGPGGL IWGGGGAGGV GGAGGGTGGA GGRAELLFGA GGAGGAGTDG
260 270 280 290 300
GPGATGGTGG HGGVGGDGGW LAPGGAGGAG GQGGAGGAGS DGGALGGTGG
310 320 330 340 350
TGGTGGAGGA GGRGALLLGA GGQGGLGGAG GQGGTGGAGG DGVLGGVGGT
360 370 380 390 400
GGKGGVGGVA GLGGAGGAAG QLFSAGGAAG AVGVGGTGGQ GGAGGAGAAG
410 420 430 440 450
ADAPASTGLT GGTGFAGGAG GVGGQGGNAI AGGINGSGGA GGTGGQGGAG
460 470 480 490 500
GMGGSGADNA SGIGADGGAG GTGGNAGAGG AGGAAGTGGT GGVVGAAGKA
510 520 530 540 550
GIGGTGGQGG AGGAGSAGTD ATATGATGGT GFSGGAGGAG GAGGNTGVGG
560 570 580 590 600
TNGSGGQGGT GGAGGAGGAG GVGADNPTGI GGTGGTGGKG GAGGAGGQGG
610 620 630 640 650
SSGAGGTNGS GGAGGTGGQG GAGGAGGAGA DNPTGIGGAG GTGGTGGAAG
660 670 680 690 700
AGGAGGAIGT GGTGGAVGSV GNAGIGGTGG TGGVGGAGGA GAAAAAGSSA
710 720 730 740 750
TGGAGFAGGA GGEGGAGGNS GVGGTNGSGG AGGAGGKGGT GGAGGSGADN
760 770 780 790 800
PTGAGFAGGA GGTGGAAGAG GAGGATGTGG TGGVVGATGS AGIGGAGGRG
810 820 830 840 850
GDGGDGASGL GLGLSGFDGG QGGQGGAGGS AGAGGINGAG GAGGNGGDGG
860 870 880 890 900
DGATGAAGLG DNGGVGGDGG AGGAAGNGGN AGVGLTAKAG DGGAAGNGGN
910 920 930 940 950
GGAGGAGGAG DNNFNGGQGG AGGQGGQGGL GGASTTSINA NGGAGGNGGT
960 970 980 990 1000
GGKGGAGGAG TLGVGGSGGT GGDGGDAGSG GGGGFGGAAG KAGGGGNGGR
1010 1020 1030 1040 1050
GGDGGDGASG LGLGLSGFDG GQGGQGGAGG SAGAGGINGA GGAGGNGGDG
1060 1070 1080 1090 1100
GDGATGAAGL GDNGGVGGDG GAGGAAGNGG NAGVGLTAKA GDGGAAGNGG
1110 1120 1130 1140 1150
NGGAGGAGGA GDNNFNGGQG GAGGQGGQGG LGGASTTSIN ANGGAGGNGG
1160 1170 1180 1190 1200
TGGKGGAGGA GTLGVGGSGG TGGDGGDAGS GGGGGFGGAA GKAGGGGNGG
1210 1220 1230 1240 1250
VGGDGGEGAS GLGLGLSGFD GGQGGQGGAG GSAGAGGING AGGAGGTGGA
1260 1270 1280 1290 1300
GGDGAPATLI GGPDGGDGGQ GGIGGDGGNA GFGAGVPGDG GDGGNAGFGA
1310 1320 1330 1340 1350
GVPGDGGIGG TGGAGGAGGA GADGDPSIDG GQGGAGGHGG QGGKGGLNST
1360 1370 1380 1390 1400
GLASAASGDG GNGGAGGAGG NGGDGDGFIG GSGGTGGTGG DAGVGGLANT
1410 1420 1430 1440 1450
GGTAGNAGIG GAGGRGGDGG AGDSGALSQD GNGFAGGQGG QGGVGGNAGA
1460 1470 1480 1490 1500
GGINGAGGTG GTGGAGGDGQ NGTTGVASEG GAGGQGGDGG QGGIGGAGGN
1510 1520 1530 1540 1550
AGFGAGVPGD GGIGGTGGAG GAGGAGADGD PSIDGGQGGA GGHGGQGGKG
1560 1570 1580 1590 1600
GLNSTGLASA ASGDGGNGGA GGAGGNGGDG DGFIGGSGGT GGTGGDAGVG
1610 1620 1630 1640 1650
GLANTGGTAG NAGIGGAGGR GGDGGAGDSG ALSQDGNGFA GGQGGQGGVG
1660 1670 1680 1690 1700
GNAGAGGING AGGTGGTGGA GGDGQNGTTG VASEGGAGGQ GGDGGQGGIG
1710 1720 1730 1740 1750
GAGGNAGFGA GVPGDGGIGG TGGAGGAGGA GADGDPSIDG GQGGAGGHGG
1760 1770 1780 1790 1800
QGGKGGLNST GLASAASGDG GNGGAGGAGG NGGAGGLGGG GGTGGTNGNG
1810 1820 1830 1840 1850
GLGGGGGNGG AGGAGGTPTG SGTEGTGGDG GDAGAGGNGG SATGVGNGGN
1860 1870 1880 1890 1900
GGDGGNGGDG GNGAPGGFGG GAGAGGLGGS GAGGGTDGDD GNGGSPGTDG

S
Length:1,901
Mass (Da):147,625
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC7B1923D5D0146CD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP46330.1

Protein sequence database of the Protein Information Resource

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PIRi
F70806

NCBI Reference Sequences

More...
RefSeqi
WP_010886172.1, NC_000962.3
YP_177979.1, NC_000962.3

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CCP46330; CCP46330; Rv3508

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
888270

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mtu:Rv3508

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|83332.12.peg.3915

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP46330.1
PIRiF70806
RefSeqiWP_010886172.1, NC_000962.3
YP_177979.1, NC_000962.3

3D structure databases

SMRiO53553
ModBaseiSearch...

Protein-protein interaction databases

STRINGi83332.Rv3508

Proteomic databases

PaxDbiO53553

Genome annotation databases

EnsemblBacteriaiCCP46330; CCP46330; Rv3508
GeneIDi888270
KEGGimtu:Rv3508
PATRICifig|83332.12.peg.3915

Organism-specific databases

TubercuListiRv3508

Phylogenomic databases

OMAiNDSGTWV

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-7785-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR000084 PE-PGRS_N
PfamiView protein in Pfam
PF00934 PE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPG54_MYCTU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O53553
Secondary accession number(s): L0TFV3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: October 16, 2019
This is version 88 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
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