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UniProtKB - O53553 (PG54_MYCTU)

Entry version 90 (17 Jun 2020)
Sequence version 1 (01 Jun 1998)
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Protein

Uncharacterized PE-PGRS family protein PE_PGRS54

Gene

PE_PGRS54

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MTBH37RV:G185E-7785-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized PE-PGRS family protein PE_PGRS54
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PE_PGRS54
Ordered Locus Names:Rv3508
ORF Names:MTV023.15
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83332 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001584 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

Organism-specific databases

Mycobacterium tuberculosis strain H37Rv genome database

More...TubercuListi		Rv3508

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000235781 – 1901Uncharacterized PE-PGRS family protein PE_PGRS54Add BLAST1901

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O53553

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		83332.Rv3508

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O53553

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 93PESequence analysisAdd BLAST93

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the mycobacterial PE family. PGRS subfamily.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Repeat

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...OMAi		WYGENIK

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000084 PE-PGRS_N

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00934 PE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O53553-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFVLIAPEF VTAAAGDLTN LGSSISAANA SAASATTQVL AAGADEVSAR 
        60         70         80         90        100
IAALFGGFGL EYQAISAQVA AYHQRFVQAL STGAGAYASA EAAAAEQIVL 
       110        120        130        140        150
GVINAPTQAL LGRPLIGDGA NATTPGGAGG AGGLLFGNGG AGAAGAPGQA 
       160        170        180        190        200
GGPGGPAGLW GNGGPGGAGG SGGGTGGAGG AGGWLFGVGG AGGVGGAGGG 
       210        220        230        240        250
TGGAGGPGGL IWGGGGAGGV GGAGGGTGGA GGRAELLFGA GGAGGAGTDG 
       260        270        280        290        300
GPGATGGTGG HGGVGGDGGW LAPGGAGGAG GQGGAGGAGS DGGALGGTGG 
       310        320        330        340        350
TGGTGGAGGA GGRGALLLGA GGQGGLGGAG GQGGTGGAGG DGVLGGVGGT 
       360        370        380        390        400
GGKGGVGGVA GLGGAGGAAG QLFSAGGAAG AVGVGGTGGQ GGAGGAGAAG 
       410        420        430        440        450
ADAPASTGLT GGTGFAGGAG GVGGQGGNAI AGGINGSGGA GGTGGQGGAG 
       460        470        480        490        500
GMGGSGADNA SGIGADGGAG GTGGNAGAGG AGGAAGTGGT GGVVGAAGKA 
       510        520        530        540        550
GIGGTGGQGG AGGAGSAGTD ATATGATGGT GFSGGAGGAG GAGGNTGVGG 
       560        570        580        590        600
TNGSGGQGGT GGAGGAGGAG GVGADNPTGI GGTGGTGGKG GAGGAGGQGG 
       610        620        630        640        650
SSGAGGTNGS GGAGGTGGQG GAGGAGGAGA DNPTGIGGAG GTGGTGGAAG 
       660        670        680        690        700
AGGAGGAIGT GGTGGAVGSV GNAGIGGTGG TGGVGGAGGA GAAAAAGSSA 
       710        720        730        740        750
TGGAGFAGGA GGEGGAGGNS GVGGTNGSGG AGGAGGKGGT GGAGGSGADN 
       760        770        780        790        800
PTGAGFAGGA GGTGGAAGAG GAGGATGTGG TGGVVGATGS AGIGGAGGRG 
       810        820        830        840        850
GDGGDGASGL GLGLSGFDGG QGGQGGAGGS AGAGGINGAG GAGGNGGDGG 
       860        870        880        890        900
DGATGAAGLG DNGGVGGDGG AGGAAGNGGN AGVGLTAKAG DGGAAGNGGN 
       910        920        930        940        950
GGAGGAGGAG DNNFNGGQGG AGGQGGQGGL GGASTTSINA NGGAGGNGGT 
       960        970        980        990       1000
GGKGGAGGAG TLGVGGSGGT GGDGGDAGSG GGGGFGGAAG KAGGGGNGGR 
      1010       1020       1030       1040       1050
GGDGGDGASG LGLGLSGFDG GQGGQGGAGG SAGAGGINGA GGAGGNGGDG 
      1060       1070       1080       1090       1100
GDGATGAAGL GDNGGVGGDG GAGGAAGNGG NAGVGLTAKA GDGGAAGNGG 
      1110       1120       1130       1140       1150
NGGAGGAGGA GDNNFNGGQG GAGGQGGQGG LGGASTTSIN ANGGAGGNGG 
      1160       1170       1180       1190       1200
TGGKGGAGGA GTLGVGGSGG TGGDGGDAGS GGGGGFGGAA GKAGGGGNGG 
      1210       1220       1230       1240       1250
VGGDGGEGAS GLGLGLSGFD GGQGGQGGAG GSAGAGGING AGGAGGTGGA 
      1260       1270       1280       1290       1300
GGDGAPATLI GGPDGGDGGQ GGIGGDGGNA GFGAGVPGDG GDGGNAGFGA 
      1310       1320       1330       1340       1350
GVPGDGGIGG TGGAGGAGGA GADGDPSIDG GQGGAGGHGG QGGKGGLNST 
      1360       1370       1380       1390       1400
GLASAASGDG GNGGAGGAGG NGGDGDGFIG GSGGTGGTGG DAGVGGLANT 
      1410       1420       1430       1440       1450
GGTAGNAGIG GAGGRGGDGG AGDSGALSQD GNGFAGGQGG QGGVGGNAGA 
      1460       1470       1480       1490       1500
GGINGAGGTG GTGGAGGDGQ NGTTGVASEG GAGGQGGDGG QGGIGGAGGN 
      1510       1520       1530       1540       1550
AGFGAGVPGD GGIGGTGGAG GAGGAGADGD PSIDGGQGGA GGHGGQGGKG 
      1560       1570       1580       1590       1600
GLNSTGLASA ASGDGGNGGA GGAGGNGGDG DGFIGGSGGT GGTGGDAGVG 
      1610       1620       1630       1640       1650
GLANTGGTAG NAGIGGAGGR GGDGGAGDSG ALSQDGNGFA GGQGGQGGVG 
      1660       1670       1680       1690       1700
GNAGAGGING AGGTGGTGGA GGDGQNGTTG VASEGGAGGQ GGDGGQGGIG 
      1710       1720       1730       1740       1750
GAGGNAGFGA GVPGDGGIGG TGGAGGAGGA GADGDPSIDG GQGGAGGHGG 
      1760       1770       1780       1790       1800
QGGKGGLNST GLASAASGDG GNGGAGGAGG NGGAGGLGGG GGTGGTNGNG 
      1810       1820       1830       1840       1850
GLGGGGGNGG AGGAGGTPTG SGTEGTGGDG GDAGAGGNGG SATGVGNGGN 
      1860       1870       1880       1890       1900
GGDGGNGGDG GNGAPGGFGG GAGAGGLGGS GAGGGTDGDD GNGGSPGTDG 

S
Length:1,901
Mass (Da):147,625
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC7B1923D5D0146CD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP46330.1

Protein sequence database of the Protein Information Resource

More...PIRi		F70806

NCBI Reference Sequences

More...RefSeqi		WP_010886172.1, NC_000962.3
YP_177979.1, NC_000962.3

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		CCP46330; CCP46330; Rv3508

Database of genes from NCBI RefSeq genomes

More...GeneIDi		888270

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mtu:Rv3508

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|83332.12.peg.3915

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP46330.1
PIRiF70806
RefSeqiWP_010886172.1, NC_000962.3
YP_177979.1, NC_000962.3

3D structure databases

SMRiO53553
ModBaseiSearch...

Protein-protein interaction databases

STRINGi83332.Rv3508

Proteomic databases

PaxDbiO53553

Genome annotation databases

EnsemblBacteriaiCCP46330; CCP46330; Rv3508
GeneIDi888270
KEGGimtu:Rv3508
PATRICifig|83332.12.peg.3915

Organism-specific databases

TubercuListiRv3508

Phylogenomic databases

OMAiWYGENIK

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-7785-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR000084 PE-PGRS_N
PfamiView protein in Pfam
PF00934 PE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPG54_MYCTU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O53553
Secondary accession number(s): L0TFV3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: June 17, 2020
This is version 90 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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