Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 104 (18 Sep 2019)
Sequence version 1 (01 Jun 1998)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

NAD-specific glutamate dehydrogenase

Gene

gdh

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the reversible conversion of L-glutamate to 2-oxoglutarate.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activity is inhibited by unphosphorylated GarA.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei845By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MTBH37RV:G185E-6711-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NAD-specific glutamate dehydrogenase (EC:1.4.1.2)
Short name:
NAD-GDH
Alternative name(s):
NAD(+)-dependent glutamate dehydrogenase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gdh
Ordered Locus Names:Rv2476c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83332 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001584 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

Organism-specific databases

Mycobacterium tuberculosis strain H37Rv genome database

More...
TubercuListi
Rv2476c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004195361 – 1624NAD-specific glutamate dehydrogenaseAdd BLAST1624

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O53203

PRoteomics IDEntifications database

More...
PRIDEi
O53203

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with (unphosphorylated) GarA.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P9WJA95EBI-6405569,EBI-6405522

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
O53203, 1 interactor

STRING: functional protein association networks

More...
STRINGi
83332.Rv2476c

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105C7I Bacteria
COG2902 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000204990

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O53203

KEGG Orthology (KO)

More...
KOi
K15371

Identification of Orthologs from Complete Genome Data

More...
OMAi
RATRWFL

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O53203

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR028971 NAD-GDH
IPR007780 NAD_Glu_DH_bac

The PANTHER Classification System

More...
PANTHERi
PTHR43403 PTHR43403, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05088 Bac_GDH, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF036761 GDH_Mll4104, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51735 SSF51735, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O53203-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTIDPGAKQD VEAWTTFTAS ADIPDWISKA YIDSYRGPRD DSSEATKAAE
60 70 80 90 100
ASWLPASLLT PAMLGAHYRL GRHRAAGESC VAVYRADDPA GFGPALQVVA
110 120 130 140 150
EHGGMLMDSV TVLLHRLGIA YAAILTPVFD VHRSPTGELL RIEPKAEGTS
160 170 180 190 200
PHLGEAWMHV ALSPAVDHKG LAEVERLLPK VLADVQRVAT DATALIATLS
210 220 230 240 250
ELAGEVESNA GGRFSAPDRQ DVGELLRWLG DGNFLLLGYQ RCRVADGMVY
260 270 280 290 300
GEGSSGMGVL RGRTGSRPRL TDDDKLLVLA QARVGSYLRY GAYPYAIAVR
310 320 330 340 350
EYVDGSVVEH RFVGLFSVAA MNADVLEIPT ISRRVREALA MAESDPSHPG
360 370 380 390 400
QLLLDVIQTV PRPELFTLSA QRLLTMARAV VDLGSQRQAL LFLRADRLQY
410 420 430 440 450
FVSCLVYMPR DRYTTAVRMQ FEDILVREFG GTRLEFTARV SESPWALMHF
460 470 480 490 500
MVRLPEVGVA GEGAAAPPVD VSEANRIRIQ GLLTEAARTW ADRLIGAAAA
510 520 530 540 550
AGSVGQADAM HYAAAFSEAY KQAVTPADAI GDIAVITELT DDSVKLVFSE
560 570 580 590 600
RDEQGVAQLT WFLGGRTASL SQLLPMLQSM GVVVLEERPF SVTRPDGLPV
610 620 630 640 650
WIYQFKISPH PTIPLAPTVA ERAATAHRFA EAVTAIWHGR VEIDRFNELV
660 670 680 690 700
MRAGLTWQQV VLLRAYAKYL RQAGFPYSQS YIESVLNEHP ATVRSLVDLF
710 720 730 740 750
EALFVPVPSG SASNRDAQAA AAAVAADIDA LVSLDTDRIL RAFASLVQAT
760 770 780 790 800
LRTNYFVTRQ GSARCRDVLA LKLNAQLIDE LPLPRPRYEI FVYSPRVEGV
810 820 830 840 850
HLRFGPVARG GLRWSDRRDD FRTEILGLVK AQAVKNAVIV PVGAKGGFVV
860 870 880 890 900
KRPPLPTGDP AADRDATRAE GVACYQLFIS GLLDVTDNVD HATASVNPPP
910 920 930 940 950
EVVRRDGDDA YLVVAADKGT ATFSDIANDV AKSYGFWLGD AFASGGSVGY
960 970 980 990 1000
DHKAMGITAR GAWEAVKRHF REIGIDTQTQ DFTVVGIGDM SGDVFGNGML
1010 1020 1030 1040 1050
LSKHIRLIAA FDHRHIFLDP NPDAAVSWAE RRRMFELPRS SWSDYDRSLI
1060 1070 1080 1090 1100
SEGGGVYSRE QKAIPLSAQV RAVLGIDGSV DGGAAEMAPP NLIRAILRAP
1110 1120 1130 1140 1150
VDLLFNGGIG TYIKAESESD ADVGDRANDP VRVNANQVRA KVIGEGGNLG
1160 1170 1180 1190 1200
VTALGRVEFD LSGGRINTDA LDNSAGVDCS DHEVNIKILI DSLVSAGTVK
1210 1220 1230 1240 1250
ADERTQLLES MTDEVAQLVL ADNEDQNDLM GTSRANAASL LPVHAMQIKY
1260 1270 1280 1290 1300
LVAERGVNRE LEALPSEKEI ARRSEAGIGL TSPELATLMA HVKLGLKEEV
1310 1320 1330 1340 1350
LATELPDQDV FASRLPRYFP TALRERFTPE IRSHQLRREI VTTMLINDLV
1360 1370 1380 1390 1400
DTAGITYAFR IAEDVGVTPI DAVRTYVATD AIFGVGHIWR RIRAANLPIA
1410 1420 1430 1440 1450
LSDRLTLDTR RLIDRAGRWL LNYRPQPLAV GAEINRFAAM VKALTPRMSE
1460 1470 1480 1490 1500
WLRGDDKAIV EKTAAEFASQ GVPEDLAYRV STGLYRYSLL DIIDIADIAD
1510 1520 1530 1540 1550
IDAAEVADTY FALMDRLGTD GLLTAVSQLP RHDRWHSLAR LAIRDDIYGA
1560 1570 1580 1590 1600
LRSLCFDVLA VGEPGESSEQ KIAEWEHLSA SRVARARRTL DDIRASGQKD
1610 1620
LATLSVAARQ IRRMTRTSGR GISG
Length:1,624
Mass (Da):176,900
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB8ED8C54C24CCFAA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP45270.1

Protein sequence database of the Protein Information Resource

More...
PIRi
C70867

NCBI Reference Sequences

More...
RefSeqi
NP_216992.1, NC_000962.3
WP_003916039.1, NZ_NVQJ01000024.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CCP45270; CCP45270; Rv2476c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
887437

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mtu:Rv2476c
mtv:RVBD_2476c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP45270.1
PIRiC70867
RefSeqiNP_216992.1, NC_000962.3
WP_003916039.1, NZ_NVQJ01000024.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiO53203, 1 interactor
STRINGi83332.Rv2476c

Proteomic databases

PaxDbiO53203
PRIDEiO53203

Genome annotation databases

EnsemblBacteriaiCCP45270; CCP45270; Rv2476c
GeneIDi887437
KEGGimtu:Rv2476c
mtv:RVBD_2476c

Organism-specific databases

TubercuListiRv2476c

Phylogenomic databases

eggNOGiENOG4105C7I Bacteria
COG2902 LUCA
HOGENOMiHOG000204990
InParanoidiO53203
KOiK15371
OMAiRATRWFL
PhylomeDBiO53203

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-6711-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR028971 NAD-GDH
IPR007780 NAD_Glu_DH_bac
PANTHERiPTHR43403 PTHR43403, 1 hit
PfamiView protein in Pfam
PF05088 Bac_GDH, 1 hit
PIRSFiPIRSF036761 GDH_Mll4104, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDHE2_MYCTU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O53203
Secondary accession number(s): L0T9R1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2012
Last sequence update: June 1, 1998
Last modified: September 18, 2019
This is version 104 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again