O33927 · LEXA_THEMA
- ProteinLexA repressor
- GenelexA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids197 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
Miscellaneous
No consensus sequence similar to the SOS-box from E.coli or from B.subtilis was found upstream of the lexA gene, suggesting the presence of another target sequence specific for the Thermotogales.
Catalytic activity
Features
Showing features for dna binding, site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 28-47 | H-T-H motif | ||||
Sequence: VREIARRFRITPRGALLHLI | ||||||
Site | 83-84 | Cleavage; by autolysis | ||||
Sequence: AG | ||||||
Active site | 119 | For autocatalytic cleavage activity | ||||
Sequence: S | ||||||
Active site | 156 | For autocatalytic cleavage activity | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | DNA binding | |
Molecular Function | serine-type endopeptidase activity | |
Biological Process | DNA repair | |
Biological Process | DNA replication | |
Biological Process | negative regulation of DNA-templated transcription | |
Biological Process | proteolysis | |
Biological Process | SOS response |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameLexA repressor
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Thermotogota > Thermotogae > Thermotogales > Thermotogaceae > Thermotoga
Accessions
- Primary accessionO33927
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000170098 | 1-197 | LexA repressor | |||
Sequence: MKDLTERQRKVLLFIEEFIEKNGYPPSVREIARRFRITPRGALLHLIALEKKGYIERKNGKPRALRISKSIRNKIPLIGEIRAGEKREAIEYLEDYIEIPESFLSSGYDHFLLKVKGESMIEEHICDGDLVLVRRQDWAQNGDIVAAMVDGEVTLKKFYQRGDTVELRPANREMSSMFFRAEKVKILGKVVGVFRKL |
Keywords
- PTM
Proteomic databases
Interaction
Structure
Sequence
- Sequence statusComplete
- Length197
- Mass (Da)22,864
- Last updated1998-01-01 v1
- ChecksumA8093B0BB3D10BFB
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U76417 EMBL· GenBank· DDBJ | AAB87145.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE000512 EMBL· GenBank· DDBJ | AAD36159.1 EMBL· GenBank· DDBJ | Genomic DNA |