O33927 · LEXA_THEMA

Function

function

Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

Miscellaneous

No consensus sequence similar to the SOS-box from E.coli or from B.subtilis was found upstream of the lexA gene, suggesting the presence of another target sequence specific for the Thermotogales.

Catalytic activity

  • Hydrolysis of Ala-|-Gly bond in repressor LexA.
    EC:3.4.21.88 (UniProtKB | ENZYME | Rhea)

Features

Showing features for dna binding, site, active site.

119720406080100120140160180
TypeIDPosition(s)Description
DNA binding28-47H-T-H motif
Site83-84Cleavage; by autolysis
Active site119For autocatalytic cleavage activity
Active site156For autocatalytic cleavage activity

GO annotations

AspectTerm
Molecular FunctionDNA binding
Molecular Functionserine-type endopeptidase activity
Biological ProcessDNA repair
Biological ProcessDNA replication
Biological Processnegative regulation of DNA-templated transcription
Biological Processproteolysis
Biological ProcessSOS response

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    LexA repressor
  • EC number

Gene names

    • Name
      lexA
    • Ordered locus names
      TM_1082

Organism names

Accessions

  • Primary accession
    O33927

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001700981-197LexA repressor

Keywords

Proteomic databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the peptidase S24 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    197
  • Mass (Da)
    22,864
  • Last updated
    1998-01-01 v1
  • Checksum
    A8093B0BB3D10BFB
MKDLTERQRKVLLFIEEFIEKNGYPPSVREIARRFRITPRGALLHLIALEKKGYIERKNGKPRALRISKSIRNKIPLIGEIRAGEKREAIEYLEDYIEIPESFLSSGYDHFLLKVKGESMIEEHICDGDLVLVRRQDWAQNGDIVAAMVDGEVTLKKFYQRGDTVELRPANREMSSMFFRAEKVKILGKVVGVFRKL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U76417
EMBL· GenBank· DDBJ
AAB87145.1
EMBL· GenBank· DDBJ
Genomic DNA
AE000512
EMBL· GenBank· DDBJ
AAD36159.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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