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Entry version 151 (13 Nov 2019)
Sequence version 4 (31 Oct 2006)
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Protein

Membrane-associated phosphatidylinositol transfer protein 1

Gene

PITPNM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes (By similarity). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium ions.By similarity4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1483226 Synthesis of PI

SIGNOR Signaling Network Open Resource

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SIGNORi
O00562

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000414

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Membrane-associated phosphatidylinositol transfer protein 1
Alternative name(s):
Drosophila retinal degeneration B homolog
Phosphatidylinositol transfer protein, membrane-associated 1
Short name:
PITPnm 1
Pyk2 N-terminal domain-interacting receptor 2
Short name:
NIR-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PITPNM1
Synonyms:DRES9, NIR2, PITPNM
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9003 PITPNM1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608794 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O00562

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Lipid droplet, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi59T → A: Prevents association with lipid droplets. 1 Publication1
Mutagenesisi59T → E: Causes association with lipid droplets. 1 Publication1
Mutagenesisi287T → A: Slightly reduced phosphorylation. Strongly reduced phosphorylation; when associated with A-794 or A-389. Loss of threonine phosphorylation; when associated with A-389; A-793 and A-1222. 1 Publication1
Mutagenesisi300S → A: No effect on phosphorylation. 1 Publication1
Mutagenesisi326S → A: No effect on phosphorylation. 1 Publication1
Mutagenesisi349 – 353EFFDA → ALLAG: Loss of interaction with VAPB. 1 Publication5
Mutagenesisi382S → A: Strongly reduced phosphorylation. 1 Publication1
Mutagenesisi389T → A: No detectable effect on phosphorylation; when associated with A-793 and A-1222. Strongly reduced phosphorylation; when associated with A-287. Loss of threonine phosphorylation; when associated with A-287; A-794 and A-1222. 1 Publication1
Mutagenesisi794T → A: No detectable effect on phosphorylation; when associated with A-389 and A-1222. Strongly reduced phosphorylation; when associated with A-287. Loss of threonine phosphorylation; when associated with A-287; A-389 and A-1222. 1 Publication1
Mutagenesisi896S → A: Reduced phosphorylation. 1 Publication1
Mutagenesisi1223T → A: No detectable effect on phosphorylation; when associated with A-389 and A-793. Loss of threonine phosphorylation; when associated with A-287; A-389 and A-794. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
9600

Open Targets

More...
OpenTargetsi
ENSG00000110697

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33337

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O00562

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1764937

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PITPNM1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002327381 – 1244Membrane-associated phosphatidylinositol transfer protein 1Add BLAST1244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei59Phosphothreonine1 Publication1
Modified residuei287Phosphothreonine; by CDK11 Publication1
Modified residuei300PhosphoserineBy similarity1
Modified residuei304PhosphoserineBy similarity1
Modified residuei319PhosphoserineBy similarity1
Modified residuei326PhosphoserineBy similarity1
Modified residuei329PhosphoserineBy similarity1
Modified residuei342PhosphoserineBy similarity1
Modified residuei345PhosphoserineBy similarity1
Modified residuei346PhosphoserineBy similarity1
Modified residuei373PhosphoserineBy similarity1
Modified residuei382Phosphoserine; by CDK11 Publication1
Modified residuei593PhosphoserineBy similarity1
Modified residuei600PhosphoserineCombined sources1
Modified residuei621PhosphoserineCombined sources1
Modified residuei896Phosphoserine1 Publication1
Modified residuei1211Omega-N-methylarginineBy similarity1
Modified residuei1218Omega-N-methylarginineBy similarity1
Modified residuei1237PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on multiple sites by CDK1 at the onset of mitosis. Phosphorylation facilitates dissociation from the Golgi complex and is required for interaction with PLK1.
Phosphorylated on threonine residues upon treatment with oleic acid.
Phosphorylated on tyrosine residues by PTK2B.

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O00562

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O00562

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O00562

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O00562

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O00562

PeptideAtlas

More...
PeptideAtlasi
O00562

PRoteomics IDEntifications database

More...
PRIDEi
O00562

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
47977 [O00562-1]
47978 [O00562-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O00562

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O00562

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000110697 Expressed in 169 organ(s), highest expression level in adenohypophysis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O00562 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O00562 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA060227
HPA062757

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PIK4CA (By similarity).

Interacts with PTK2B via its C-terminus.

Interacts with RHOA. Has higher affinity for the inactive, GDP-bound form of RHOA. The CDK1-phosphorylated form interacts with PLK1.

Interacts with VAPB.

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q128003EBI-2861268,EBI-717422

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114965, 8 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
O00562

Protein interaction database and analysis system

More...
IntActi
O00562, 8 interactors

Molecular INTeraction database

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MINTi
O00562

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000348772

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O00562

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini686 – 880DDHDPROSITE-ProRule annotationAdd BLAST195

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi310 – 319Poly-Ser10

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3668 Eukaryota
COG5083 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161522

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000294231

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O00562

Identification of Orthologs from Complete Genome Data

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OMAi
FSKQWSS

Database of Orthologous Groups

More...
OrthoDBi
122895at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O00562

TreeFam database of animal gene trees

More...
TreeFami
TF312967

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.530.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004177 DDHD_dom
IPR036412 HAD-like_sf
IPR031315 LNS2/PITP
IPR001666 PI_transfer
IPR023393 START-like_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10658 PTHR10658, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02862 DDHD, 1 hit
PF02121 IP_trans, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00391 PITRANSFER

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01127 DDHD, 1 hit
SM00775 LNS2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56784 SSF56784, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51043 DDHD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O00562-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLIKEYHILL PMSLDEYQVA QLYMIQKKSR EESSGEGSGV EILANRPYTD
60 70 80 90 100
GPGGSGQYTH KVYHVGSHIP GWFRALLPKA ALQVEEESWN AYPYTRTRYT
110 120 130 140 150
CPFVEKFSIE IETYYLPDGG QQPNVFNLSG AERRQRILDT IDIVRDAVAP
160 170 180 190 200
GEYKAEEDPR LYHSVKTGRG PLSDDWARTA AQTGPLMCAY KLCKVEFRYW
210 220 230 240 250
GMQAKIEQFI HDVGLRRVML RAHRQAWCWQ DEWTELSMAD IRALEEETAR
260 270 280 290 300
MLAQRMAKCN TGSEGSEAQP PGKPSTEARS AASNTGTPDG PEAPPGPDAS
310 320 330 340 350
PDASFGKQWS SSSRSSYSSQ HGGAVSPQSL SEWRMQNIAR DSENSSEEEF
360 370 380 390 400
FDAHEGFSDS EEVFPKEMTK WNSNDFIDAF ASPVEAEGTP EPGAEAAKGI
410 420 430 440 450
EDGAQAPRDS EGLDGAGELG AEACAVHALF LILHSGNILD SGPGDANSKQ
460 470 480 490 500
ADVQTLSSAF EAVTRIHFPE ALGHVALRLV PCPPICAAAY ALVSNLSPYS
510 520 530 540 550
HDGDSLSRSQ DHIPLAALPL LATSSSRYQG AVATVIARTN QAYSAFLRSP
560 570 580 590 600
EGAGFCGQVA LIGDGVGGIL GFDALCHSAN AGTGSRGSSR RGSMNNELLS
610 620 630 640 650
PEFGPVRDPL ADGVEGLGRG SPEPSALPPQ RIPSDMASPE PEGSQNSLQA
660 670 680 690 700
APATTSSWEP RRASTAFCPP AASSEAPDGP SSTARLDFKV SGFFLFGSPL
710 720 730 740 750
GLVLALRKTV MPALEAAQMR PACEQIYNLF HAADPCASRL EPLLAPKFQA
760 770 780 790 800
IAPLTVPRYQ KFPLGDGSSL LLADTLQTHS SLFLEELEML VPSTPTSTSG
810 820 830 840 850
AFWKGSELAT DPPAQPAAPS TTSEVVKILE RWWGTKRIDY SLYCPEALTA
860 870 880 890 900
FPTVTLPHLF HASYWESADV VAFILRQVIE KERPQLAECE EPSIYSPAFP
910 920 930 940 950
REKWQRKRTQ VKIRNVTSNH RASDTVVCEG RPQVLSGRFM YGPLDVVTLT
960 970 980 990 1000
GEKVDVYIMT QPLSGKWIHF GTEVTNSSGR LTFPVPPERA LGIGVYPVRM
1010 1020 1030 1040 1050
VVRGDHTYAE CCLTVVARGT EAVVFSIDGS FTASVSIMGS DPKVRAGAVD
1060 1070 1080 1090 1100
VVRHWQDSGY LIVYVTGRPD MQKHRVVAWL SQHNFPHGVV SFCDGLTHDP
1110 1120 1130 1140 1150
LRQKAMFLQS LVQEVELNIV AGYGSPKDVA VYAALGLSPS QTYIVGRAVR
1160 1170 1180 1190 1200
KLQAQCQFLS DGYVAHLGQL EAGSHSHASS GPPRAALGKS SYGVAAPVDF
1210 1220 1230 1240
LRKQSQLLRS RGPSQAEREG PGTPPTTLAR GKARSISLKL DSEE
Length:1,244
Mass (Da):134,848
Last modified:October 31, 2006 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF4B66E98B085E9C0
GO
Isoform 2 (identifier: O00562-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     716-716: Missing.

Show »
Length:1,243
Mass (Da):134,777
Checksum:i6262539C57A79DA6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PMS0E9PMS0_HUMAN
Membrane-associated phosphatidylino...
PITPNM1
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMZ6E9PMZ6_HUMAN
Membrane-associated phosphatidylino...
PITPNM1
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PSD1E9PSD1_HUMAN
Membrane-associated phosphatidylino...
PITPNM1
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNU6E9PNU6_HUMAN
Membrane-associated phosphatidylino...
PITPNM1
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti931R → P in AAK01444 (PubMed:10022914).Curated1
Sequence conflicti1034S → G in AAR06909 (PubMed:15627748).Curated1
Sequence conflicti1116E → G in CAA67224 (PubMed:9680295).Curated1
Sequence conflicti1133A → T in CAA67224 (PubMed:9680295).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_021157716Missing in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X98654 mRNA Translation: CAA67224.1
AF334584 mRNA Translation: AAK01444.1
AY429102 mRNA Translation: AAR06909.1
AP001184 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74638.1
BC022230 mRNA Translation: AAH22230.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS31620.1 [O00562-1]
CCDS44659.1 [O00562-2]

NCBI Reference Sequences

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RefSeqi
NP_001124320.1, NM_001130848.1 [O00562-2]
NP_004901.2, NM_004910.2 [O00562-1]
XP_016874075.1, XM_017018586.1 [O00562-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000356404; ENSP00000348772; ENSG00000110697 [O00562-1]
ENST00000436757; ENSP00000398787; ENSG00000110697 [O00562-2]
ENST00000534749; ENSP00000437286; ENSG00000110697 [O00562-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9600

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9600

UCSC genome browser

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UCSCi
uc001olx.3 human [O00562-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98654 mRNA Translation: CAA67224.1
AF334584 mRNA Translation: AAK01444.1
AY429102 mRNA Translation: AAR06909.1
AP001184 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74638.1
BC022230 mRNA Translation: AAH22230.1
CCDSiCCDS31620.1 [O00562-1]
CCDS44659.1 [O00562-2]
RefSeqiNP_001124320.1, NM_001130848.1 [O00562-2]
NP_004901.2, NM_004910.2 [O00562-1]
XP_016874075.1, XM_017018586.1 [O00562-1]

3D structure databases

SMRiO00562
ModBaseiSearch...

Protein-protein interaction databases

BioGridi114965, 8 interactors
ELMiO00562
IntActiO00562, 8 interactors
MINTiO00562
STRINGi9606.ENSP00000348772

Chemistry databases

ChEMBLiCHEMBL1764937
SwissLipidsiSLP:000000414

PTM databases

iPTMnetiO00562
PhosphoSitePlusiO00562

Polymorphism and mutation databases

BioMutaiPITPNM1

Proteomic databases

EPDiO00562
jPOSTiO00562
MassIVEiO00562
MaxQBiO00562
PaxDbiO00562
PeptideAtlasiO00562
PRIDEiO00562
ProteomicsDBi47977 [O00562-1]
47978 [O00562-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9600

Genome annotation databases

EnsembliENST00000356404; ENSP00000348772; ENSG00000110697 [O00562-1]
ENST00000436757; ENSP00000398787; ENSG00000110697 [O00562-2]
ENST00000534749; ENSP00000437286; ENSG00000110697 [O00562-1]
GeneIDi9600
KEGGihsa:9600
UCSCiuc001olx.3 human [O00562-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9600
DisGeNETi9600

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PITPNM1
HGNCiHGNC:9003 PITPNM1
HPAiHPA060227
HPA062757
MIMi608794 gene
neXtProtiNX_O00562
OpenTargetsiENSG00000110697
PharmGKBiPA33337

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3668 Eukaryota
COG5083 LUCA
GeneTreeiENSGT00940000161522
HOGENOMiHOG000294231
InParanoidiO00562
OMAiFSKQWSS
OrthoDBi122895at2759
PhylomeDBiO00562
TreeFamiTF312967

Enzyme and pathway databases

ReactomeiR-HSA-1483226 Synthesis of PI
SIGNORiO00562

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PITPNM1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PITPNM1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9600
PharosiO00562

Protein Ontology

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PROi
PR:O00562

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000110697 Expressed in 169 organ(s), highest expression level in adenohypophysis
ExpressionAtlasiO00562 baseline and differential
GenevisibleiO00562 HS

Family and domain databases

Gene3Di3.30.530.20, 1 hit
InterProiView protein in InterPro
IPR004177 DDHD_dom
IPR036412 HAD-like_sf
IPR031315 LNS2/PITP
IPR001666 PI_transfer
IPR023393 START-like_dom_sf
PANTHERiPTHR10658 PTHR10658, 1 hit
PfamiView protein in Pfam
PF02862 DDHD, 1 hit
PF02121 IP_trans, 1 hit
PRINTSiPR00391 PITRANSFER
SMARTiView protein in SMART
SM01127 DDHD, 1 hit
SM00775 LNS2, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
PROSITEiView protein in PROSITE
PS51043 DDHD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPITM1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O00562
Secondary accession number(s): A6NME4
, Q6T7X3, Q8TBN3, Q9BZ73
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: October 31, 2006
Last modified: November 13, 2019
This is version 151 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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