UniProtKB - M9PFN0 (HZG_DROME)
Protein
Phosphatase Herzog
Gene
hzg
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Prion-like membrane-associated phosphatase (PubMed:31491385). Phosphatase activity depends on amyloid-like assembly at the membrane (PubMed:31491385). Might have a role in establishment of segment polarity in embryos (PubMed:31491385).1 Publication
Catalytic activityi
- EC:3.1.3.161 Publication
Activity regulationi
Phosphatase activity requires amyloid-like aggregation on the membrane.1 Publication
GO - Molecular functioni
- phosphoprotein phosphatase activity Source: FlyBase
- protein serine phosphatase activity Source: UniProtKB-EC
- protein threonine phosphatase activity Source: UniProtKB-EC
- RNA polymerase II CTD heptapeptide repeat phosphatase activity Source: FlyBase
GO - Biological processi
- positive regulation of embryonic development Source: FlyBase
- protein dephosphorylation Source: FlyBase
Keywordsi
Molecular function | Hydrolase |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:hzg1 PublicationImported Synonyms:24664944Imported ORF Names:CG5830Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0036556, CG5830 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Peripheral membrane protein 1 Publication
Note: During embryonic development shows diffuse localization between stages 1-5 and then shows foci formation at the cell membrane that persist till later stages.1 Publication
Plasma Membrane
- plasma membrane Source: FlyBase
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 118 – 120 | DLD → ELN: Loss of phosphatase activity. 1 Publication | 3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000448931 | 1 – 352 | Phosphatase HerzogAdd BLAST | 352 |
Proteomic databases
PaxDbi | M9PFN0 |
PRIDEi | M9PFN0 |
Expressioni
Developmental stagei
Expressed ubiquitously throughout embryonic development (at protein level).1 Publication
Gene expression databases
Bgeei | FBgn0036556, Expressed in brain and 38 other tissues |
ExpressionAtlasi | M9PFN0, baseline and differential |
Interactioni
Subunit structurei
Protein-protein interaction databases
IntActi | M9PFN0, 13 interactors |
STRINGi | 7227.FBpp0305756 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 108 – 266 | FCP1 homologyPROSITE-ProRule annotationAdd BLAST | 159 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 102 | Prion-like domain necessary for both protein assembly and membrane targeting1 PublicationAdd BLAST | 102 | |
Regioni | 103 – 267 | Mediates substrate recognition1 PublicationAdd BLAST | 165 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 281 – 350 | Gln-richPROSITE-ProRule annotationAdd BLAST | 70 |
Phylogenomic databases
eggNOGi | KOG1605, Eukaryota |
GeneTreei | ENSGT01020000230486 |
HOGENOMi | CLU_020262_4_0_1 |
OMAi | NQQHPQE |
OrthoDBi | 1176152at2759 |
Family and domain databases
Gene3Di | 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR011948, Dullard_phosphatase IPR004274, FCP1_dom IPR036412, HAD-like_sf IPR023214, HAD_sf IPR040078, RNA_Pol_CTD_Phosphatase |
Pfami | View protein in Pfam PF03031, NIF, 1 hit |
SFLDi | SFLDG01124, C0.1:_RNA_Pol_CTD_Phosphatase, 1 hit |
SMARTi | View protein in SMART SM00577, CPDc, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit |
TIGRFAMsi | TIGR02251, HIF-SF_euk, 1 hit |
PROSITEi | View protein in PROSITE PS50969, FCP1, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform BImported (identifier: M9PFN0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDATSIITQV SRDDEQLNVY PSYPNDKDAW LGFSGSVWLP DCPADHAQLT
60 70 80 90 100
HDVDRLKPQK RGLFHSLLCC WRRNRTKTNQ NGTQIDGSTT PPPLPDQQRY
110 120 130 140 150
LLPQVRLTDM HRKCMVIDLD ETLVHSSFKP IPNADFIVPV EIDGTVHQVY
160 170 180 190 200
VLKRPHVDEF LQKMGELYEC VLFTASLAKY ADPVADLLDK WNVFRARLFR
210 220 230 240 250
ESCVYYRGNY IKDLNRLGRD LQKIVIVDNS PASYIFHPDN AVPVKSWFDD
260 270 280 290 300
VTDCELRELI PLFEKLSKVD SVYSVLCNSN QPLNNQTNQQ QHPQELQQAP
310 320 330 340 350
NQLHQQLQQQ QQQQTISATT VITQATTLSA PTMLNQQQTS PPSPQSELLQ
KT
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 11 | S → F in AAQ22453 (Ref. 3) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_060469 | 29 – 51 | Missing in isoform A. Add BLAST | 23 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AGB94605.1 AE014296 Genomic DNA Translation: AAF49553.2 BT009984 mRNA Translation: AAQ22453.1 BT050447 mRNA Translation: ACJ13154.1 |
RefSeqi | NP_001261912.1, NM_001274983.2 [M9PFN0-1] NP_648825.1, NM_140568.3 [M9PFN0-2] |
Genome annotation databases
EnsemblMetazoai | FBtr0075521; FBpp0075276; FBgn0036556 [M9PFN0-2] FBtr0333579; FBpp0305756; FBgn0036556 [M9PFN0-1] |
GeneIDi | 39748 |
KEGGi | dme:Dmel_CG5830 |
UCSCi | CG5830-RA, d. melanogaster |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AGB94605.1 AE014296 Genomic DNA Translation: AAF49553.2 BT009984 mRNA Translation: AAQ22453.1 BT050447 mRNA Translation: ACJ13154.1 |
RefSeqi | NP_001261912.1, NM_001274983.2 [M9PFN0-1] NP_648825.1, NM_140568.3 [M9PFN0-2] |
3D structure databases
SMRi | M9PFN0 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | M9PFN0, 13 interactors |
STRINGi | 7227.FBpp0305756 |
Proteomic databases
PaxDbi | M9PFN0 |
PRIDEi | M9PFN0 |
Genome annotation databases
EnsemblMetazoai | FBtr0075521; FBpp0075276; FBgn0036556 [M9PFN0-2] FBtr0333579; FBpp0305756; FBgn0036556 [M9PFN0-1] |
GeneIDi | 39748 |
KEGGi | dme:Dmel_CG5830 |
UCSCi | CG5830-RA, d. melanogaster |
Organism-specific databases
CTDi | 39748 |
FlyBasei | FBgn0036556, CG5830 |
Phylogenomic databases
eggNOGi | KOG1605, Eukaryota |
GeneTreei | ENSGT01020000230486 |
HOGENOMi | CLU_020262_4_0_1 |
OMAi | NQQHPQE |
OrthoDBi | 1176152at2759 |
Miscellaneous databases
BioGRID-ORCSi | 39748, 0 hits in 3 CRISPR screens |
GenomeRNAii | 39748 |
PROi | PR:M9PFN0 |
Gene expression databases
Bgeei | FBgn0036556, Expressed in brain and 38 other tissues |
ExpressionAtlasi | M9PFN0, baseline and differential |
Family and domain databases
Gene3Di | 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR011948, Dullard_phosphatase IPR004274, FCP1_dom IPR036412, HAD-like_sf IPR023214, HAD_sf IPR040078, RNA_Pol_CTD_Phosphatase |
Pfami | View protein in Pfam PF03031, NIF, 1 hit |
SFLDi | SFLDG01124, C0.1:_RNA_Pol_CTD_Phosphatase, 1 hit |
SMARTi | View protein in SMART SM00577, CPDc, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit |
TIGRFAMsi | TIGR02251, HIF-SF_euk, 1 hit |
PROSITEi | View protein in PROSITE PS50969, FCP1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HZG_DROME | |
Accessioni | M9PFN0Primary (citable) accession number: M9PFN0 Secondary accession number(s): Q7YU53, Q9VUX0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2020 |
Last sequence update: | June 26, 2013 | |
Last modified: | April 7, 2021 | |
This is version 68 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase