M3YBQ2 · M3YBQ2_MUSPF
- ProteinADAM metallopeptidase with thrombospondin type 1 motif 8
- GeneADAMTS8
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids875 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 206 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 206 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 289 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 289 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 296 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 347 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Active site | 348 | |||||
Sequence: E | ||||||
Binding site | 351 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 357 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 408 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 411 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 411 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | collagen-containing extracellular matrix | |
Cellular Component | extracellular region | |
Molecular Function | metalloendopeptidase activity | |
Molecular Function | zinc ion binding | |
Biological Process | extracellular matrix organization | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Musteloidea > Mustelidae > Mustelinae > Mustela
Accessions
- Primary accessionM3YBQ2
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 278↔331 | |||||
Sequence: CSWQRRFNQPSDRHPEHFDTAILLTRQNFCGKEGMCDTLGVADIGTICDPNKSC | ||||||
Disulfide bond | 307↔313 | |||||
Sequence: CGKEGMC | ||||||
Disulfide bond | 325↔408 | |||||
Sequence: CDPNKSCSVIEDEGLQAAYTLAHELGHVLSMPHDDSKPCARLFGPMGKHHMMAPLFVHLNKTLPWSPCSAMYLTELLDGGHGDC | ||||||
Disulfide bond | 363↔392 | |||||
Sequence: CARLFGPMGKHHMMAPLFVHLNKTLPWSPC | ||||||
Disulfide bond | 436↔461 | |||||
Sequence: CKQIFGLSFRHCPNTSAQDVCAQLWC | ||||||
Disulfide bond | 447↔470 | |||||
Sequence: CPNTSAQDVCAQLWCHMDGAEPLC | ||||||
Disulfide bond | 456↔491 | |||||
Sequence: CAQLWCHMDGAEPLCHTKNGSLPWADGTPCGPGHLC | ||||||
Disulfide bond | 485↔496 | |||||
Sequence: CGPGHLCWDGSC | ||||||
Disulfide bond | 522↔559 | |||||
Sequence: CSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSC | ||||||
Disulfide bond | 526↔564 | |||||
Sequence: CGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEEC | ||||||
Disulfide bond | 537↔549 | |||||
Sequence: CKDPEPQNGGRYC |
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 95-194 | Disordered | ||||
Sequence: FTIQPQGSGGSLRQPHRLQRWGHGARRETPGLAASEAHPLPGGPEWEVKGEDQRQERGDEERESEEVEEEEEMEEEEEGGKEEEAEGASELPPPLGATSR | ||||||
Compositional bias | 139-155 | Basic and acidic residues | ||||
Sequence: EWEVKGEDQRQERGDEE | ||||||
Compositional bias | 156-178 | Acidic residues | ||||
Sequence: RESEEVEEEEEMEEEEEGGKEEE | ||||||
Domain | 203-413 | Peptidase M12B | ||||
Sequence: RFVETLLVADASMAAFYGADLQNHILTLMSVAARIYKHPSIKNAIHLMVVKVLIVEDEKWGPEVSDNGGLTLRNFCSWQRRFNQPSDRHPEHFDTAILLTRQNFCGKEGMCDTLGVADIGTICDPNKSCSVIEDEGLQAAYTLAHELGHVLSMPHDDSKPCARLFGPMGKHHMMAPLFVHLNKTLPWSPCSAMYLTELLDGGHGDCLLDAP |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length875
- Mass (Da)95,499
- Last updated2013-05-01 v1
- ChecksumCE66686E19C68DC2
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 139-155 | Basic and acidic residues | ||||
Sequence: EWEVKGEDQRQERGDEE | ||||||
Compositional bias | 156-178 | Acidic residues | ||||
Sequence: RESEEVEEEEEMEEEEEGGKEEE |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AEYP01059486 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |