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Entry version 59 (07 Apr 2021)
Sequence version 2 (22 Jul 2015)
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Protein
Submitted name:

Erbb2-interacting protein

Gene

Erbin

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Erbb2-interacting proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ErbinImported
Synonyms:Erbb2ipImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Rat genome database

More...
RGDi
1562952, Erbin

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
M0R9T2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
M0R9T2

PRoteomics IDEntifications database

More...
PRIDEi
M0R9T2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000047137, Expressed in lung and 20 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
M0R9T2, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000066263

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
M0R9T2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1167 – 1256PDZInterPro annotationAdd BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni270 – 300DisorderedSequence analysisAdd BLAST31
Regioni314 – 409DisorderedSequence analysisAdd BLAST96
Regioni434 – 489DisorderedSequence analysisAdd BLAST56
Regioni628 – 675DisorderedSequence analysisAdd BLAST48
Regioni798 – 824DisorderedSequence analysisAdd BLAST27
Regioni876 – 902DisorderedSequence analysisAdd BLAST27
Regioni914 – 993DisorderedSequence analysisAdd BLAST80
Regioni1044 – 1086DisorderedSequence analysisAdd BLAST43
Regioni1099 – 1130DisorderedSequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi270 – 285PolyampholyteSequence analysisAdd BLAST16
Compositional biasi314 – 362PolyampholyteSequence analysisAdd BLAST49
Compositional biasi365 – 388PolarSequence analysisAdd BLAST24
Compositional biasi435 – 449PolyampholyteSequence analysisAdd BLAST15
Compositional biasi450 – 489PolarSequence analysisAdd BLAST40
Compositional biasi876 – 894PolarSequence analysisAdd BLAST19
Compositional biasi914 – 975PolarSequence analysisAdd BLAST62
Compositional biasi1106 – 1125PolarSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LAP (LRR and PDZ) protein family.ARBA annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Leucine-rich repeatARBA annotation, RepeatARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0619, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000165286

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004220_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
M0R9T2

Identification of Orthologs from Complete Genome Data

More...
OMAi
QVVNKDM

Database of Orthologous Groups

More...
OrthoDBi
100824at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.10, 1 hit
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032927, Erbin
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR001478, PDZ
IPR036034, PDZ_sf

The PANTHER Classification System

More...
PANTHERi
PTHR23119:SF46, PTHR23119:SF46, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13855, LRR_8, 2 hits
PF00595, PDZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369, LRR_TYP, 7 hits
SM00228, PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156, SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450, LRR, 7 hits
PS50106, PDZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

M0R9T2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSQEVPEVL EQLSGLREFW MDGNRLTFIP GFIGSLRQLT YLDVSKNNIE
60 70 80 90 100
MVEEGISTCE NLQDFLLSSN SLQQLPETIG SLKNVTTLKI DENQLMYLPD
110 120 130 140 150
SIGGLRSIEE LDCSFNEIEA LPSSIGQLTN IRTFAADHNY LQQLPPEIGN
160 170 180 190 200
WKNVTVLFLH SNKLETLPEE MGDMQKLKVI NLSDNRLKNL PFSFTKLQQL
210 220 230 240 250
TAMWLSDNQS KPLIPLQKET DSETQKMVLT NYMFPQQPRT EDVMFISDNE
260 270 280 290 300
SFNPALWEEQ RKQRAQVAFE CDEDKDEREA PPREGNLKRY PTPYPDELKN
310 320 330 340 350
MVKTVQTIVH RLKDEETNEE SGRDLKQHED QQVVNKDKGV KPSESITTKS
360 370 380 390 400
KLDEREKYMN SVPKTSEPEA ETNAGNSPVT TNRKSSGNMK HLVNHDDVFE
410 420 430 440 450
ESEELSSDEE MKMAEMRPPL IETSINQPKV VALSNNKKDD AKDTDSLSDE
460 470 480 490 500
VTHNSNQNNS NCSSPSRMSD SVSLNTDSSQ DTALCSPAKQ IPIDSNSKIR
510 520 530 540 550
QEDENFNSLL QNGVNLNNSP EEKFKINDKK DFKLPEYDLN IEEQLVLIEK
560 570 580 590 600
DVDSKATSED SHQLDHINMN LNKLVTNNIF QPEIMERSKM QDIVLGTGFL
610 620 630 640 650
SIHSKSEAEH IENGNKFLNS ESINKVNGLS EDTAQSPGRI EPQNTSPADV
660 670 680 690 700
GISKSTEDLS PQRSGPAGSV VKSHSITNME TGGLKIYDIL SDDGPQPPGA
710 720 730 740 750
TVKVASTMDG KNIVRSKSAT LLYDQPLQVF TASSSSSELL SGTKAVFKFD
760 770 780 790 800
SNHNPEDPDI IRASIVPGPQ SIPQLYGPPQ YNVQYSGSAA MKDTLWHPKQ
810 820 830 840 850
NPQIDPVSFP PQRLPRSESA ENHSYTKHSA NMNFSNHNNV RANTAYHLHQ
860 870 880 890 900
RLAPTRHGEM WAVSPNDRLV PAVSRTTVQR QSSVSSTASV NLGDPGPTRR
910 920 930 940 950
TEGDYLSYRE LHSMGRTPVT SGSQRPLSAR AFSIDGPSTS RPQSARPSIS
960 970 980 990 1000
EIPERTMSVS DFNYSRTSPS KRPNARVGSE HSLLDPPGKS KVPHDWREQV
1010 1020 1030 1040 1050
LRHIEAKKLE KSMLSRSFSS NLTAVSSSHY GSSRDLHGSQ GSLALNVADG
1060 1070 1080 1090 1100
RGSGGHSFRH PQTSSPGDCC QDDRFMSGEQ NHPLGALSHR DLRDSLMKMP
1110 1120 1130 1140 1150
LSNGQMGQPL RPQANYSQTH HPPQASVARH PSREQLIDYL MLKVAHQPPY
1160 1170 1180 1190 1200
THPHCSPRQG HELAKQEIRV RVEKDPELGF SISGGVGGRG NPFRPDDDGI
1210 1220 1230 1240 1250
FVTRVQPEGP ASKLLQPGDK IIQANGYSFI NIEHGQAVSL LKTFHNAVEL

IIVREVSS
Length:1,258
Mass (Da):140,128
Last modified:July 22, 2015 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3F1CA7A0D06A41C9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07007894 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_017446668.1, XM_017591179.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000075196; ENSRNOP00000066263; ENSRNOG00000047137

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
365661

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:365661

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07007894 Genomic DNA No translation available.
RefSeqiXP_017446668.1, XM_017591179.1

3D structure databases

SMRiM0R9T2
ModBaseiSearch...

Protein-protein interaction databases

IntActiM0R9T2, 1 interactor
STRINGi10116.ENSRNOP00000066263

Proteomic databases

jPOSTiM0R9T2
PaxDbiM0R9T2
PRIDEiM0R9T2

Genome annotation databases

EnsembliENSRNOT00000075196; ENSRNOP00000066263; ENSRNOG00000047137
GeneIDi365661
KEGGirno:365661

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55914
RGDi1562952, Erbin

Phylogenomic databases

eggNOGiKOG0619, Eukaryota
GeneTreeiENSGT00940000165286
HOGENOMiCLU_004220_1_0_1
InParanoidiM0R9T2
OMAiQVVNKDM
OrthoDBi100824at2759

Gene expression databases

BgeeiENSRNOG00000047137, Expressed in lung and 20 other tissues

Family and domain databases

Gene3Di2.30.42.10, 1 hit
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR032927, Erbin
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR001478, PDZ
IPR036034, PDZ_sf
PANTHERiPTHR23119:SF46, PTHR23119:SF46, 1 hit
PfamiView protein in Pfam
PF13855, LRR_8, 2 hits
PF00595, PDZ, 1 hit
SMARTiView protein in SMART
SM00369, LRR_TYP, 7 hits
SM00228, PDZ, 1 hit
SUPFAMiSSF50156, SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51450, LRR, 7 hits
PS50106, PDZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM0R9T2_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M0R9T2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: July 22, 2015
Last modified: April 7, 2021
This is version 59 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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