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Entry version 46 (16 Oct 2019)
Sequence version 1 (28 Nov 2012)
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Protein

Methionine S-methyltransferase

Gene

101760501

Organism
Setaria italica (Foxtail millet) (Panicum italicum)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotation, Transferase
LigandS-adenosyl-L-methioninePROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Methionine S-methyltransferasePROSITE-ProRule annotation (EC:2.1.1.12PROSITE-ProRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:101760501Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSetaria italica (Foxtail millet) (Panicum italicum)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri4555 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaePanicodaePaniceaeCenchrinaeSetaria

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
K3Z3C4 baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
4555.Si021042m

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IF7S Eukaryota
ENOG410Y93S LUCA

Identification of Orthologs from Complete Genome Data

More...
OMAi
LGANGHY

Database of Orthologous Groups

More...
OrthoDBi
93776at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.640.10, 1 hit
3.90.1150.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004839 Aminotransferase_I/II
IPR025779 Met_S-MeTrfase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
IPR029063 SAM-dependent_MTases
IPR007848 Small_mtfrase_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00155 Aminotran_1_2, 1 hit
PF05175 MTS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53335 SSF53335, 1 hit
SSF53383 SSF53383, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51555 SAM_MT12, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

K3Z3C4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPAVEDKD VDAFLADCRT SGDAAYGAAK AVLERLHASA TRPAARRLLG
60 70 80 90 100
AVRRRFAADP AAGEDCFRTF HFRIHDVVLD PHVQGFQQRK KLTMMEIPSI
110 120 130 140 150
FIPEDWSFTF YEGLNRHPDS IFRDKTVAEL GCGNGWISIA LAEKWSPLKV
160 170 180 190 200
YGLDINPRAV KIAWINLYLN ALDDDGLPIY DGEGKTLLDR VEFYESDLLS
210 220 230 240 250
YCRDNKIELD RIVGCIPQIL NPNPEAMSKI ITENSSEEFL YSLSNYCALQ
260 270 280 290 300
GFVEDQFGLG LIARAVEEGI AVIKPSGIMV FNMGGRPGQG VCQRLFERRG
310 320 330 340 350
FRITKLWQTK IMQAADTDIS ALVEIEKNSR HRFEFFMDLV GDQPICARTA
360 370 380 390 400
WAYMKSGGRI SHALSVYSCQ LRQPNQVKKI FEFLKDGFHE VSSSLDLSFD
410 420 430 440 450
DDSVADEKIP FLAYLASFLK ENKSNPCEPP AGCLNFRKLV AGFMKSYHHI
460 470 480 490 500
PLTPDNVVVF PSRAVAIENA LQLFSPALAI VDEHLTRHLP KQWLTSLAIE
510 520 530 540 550
GRADCNHAEG TVTVIEAPRQ SDLLIELIRK LKPQVVVTGM AQFEAITSAA
560 570 580 590 600
FENLLNATKD VGSRLFLDIS EHLELSSLPS SNGVLKYLAG KTLPSHAAIL
610 620 630 640 650
CGLVKNQVYS DLEVAFAISE DAAVYKALSQ TIELLEGHTS LISQHYYGCL
660 670 680 690 700
FHELLAFQIA DRHPQQERQP AEVIPQQMIG FSDPAMSTLK AAEFFIPDSN
710 720 730 740 750
ESSVIHMDLD RSFLPVPSAV NASVFESFVR QNITDSETDV HSSIQQLVKD
760 770 780 790 800
SYGLSVDGCS EIIYGNASLA LFNKLVLCCM QEQGTLLFPL GTNGHYISAA
810 820 830 840 850
KFVNASTLTI PTTFSSGFKI EPKVLADTLK NVSRPWVYIS GPTINPTGFL
860 870 880 890 900
YSDSDIQELL SVCAEYGARV VIDTSFSGLE YQTDGWSRWN LEGCLSSLKC
910 920 930 940 950
SKPSFSVVLL GELSFELIAA GHDFGFVILN DPSLVDAFHS FPSLSRPHST
960 970 980 990 1000
LKYTFKKLLG LKNQKDQHFS DLMAEQKDEL KNRANQLIKT LQSCGWDVAS
1010 1020 1030 1040 1050
GCAGISMLAK PTAYIGKPFK ADGFEGKLDA SNIREAILRA TGLCINSSSW
1060 1070 1080 1090
TGIPDYCRFS FALESGEFER AMGCITRFKE LVLGGNAQTQ MNGN
Length:1,094
Mass (Da):121,041
Last modified:November 28, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i554F17217ACA640B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AGNK02001452 Genomic DNA No translation available.

NCBI Reference Sequences

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RefSeqi
XP_004960581.1, XM_004960524.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
KQL13447; KQL13447; SETIT_021042mg

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
101760501

Gramene; a comparative resource for plants

More...
Gramenei
KQL13447; KQL13447; SETIT_021042mg

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AGNK02001452 Genomic DNA No translation available.
RefSeqiXP_004960581.1, XM_004960524.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi4555.Si021042m

Genome annotation databases

EnsemblPlantsiKQL13447; KQL13447; SETIT_021042mg
GeneIDi101760501
GrameneiKQL13447; KQL13447; SETIT_021042mg

Phylogenomic databases

eggNOGiENOG410IF7S Eukaryota
ENOG410Y93S LUCA
OMAiLGANGHY
OrthoDBi93776at2759

Gene expression databases

ExpressionAtlasiK3Z3C4 baseline

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR025779 Met_S-MeTrfase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
IPR029063 SAM-dependent_MTases
IPR007848 Small_mtfrase_dom
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
PF05175 MTS, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
SSF53383 SSF53383, 2 hits
PROSITEiView protein in PROSITE
PS51555 SAM_MT12, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK3Z3C4_SETIT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: K3Z3C4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: October 16, 2019
This is version 46 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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