I6DRB7 · I6DRB7_SHIBO
- ProteinRibonucleoside-diphosphate reductase subunit beta
- GenenrdF
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids304 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Catalytic activity
- a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol
CHEBI:73316 + RHEA-COMP:10700 CHEBI:50058 Position: n/n+3+ CHEBI:15377 = CHEBI:57930 + RHEA-COMP:10698 CHEBI:29950 Position: nCHEBI:29950 Position: n+3
Cofactor
Note: Binds 2 iron ions per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 67 | Fe cation 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 98 | Fe cation 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 101 | Fe cation 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Active site | 105 | |||||
Sequence: Y | ||||||
Binding site | 158 | Fe cation 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 192 | Fe cation 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 195 | Fe cation 2 (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | ribonucleoside-diphosphate reductase complex | |
Molecular Function | metal ion binding | |
Molecular Function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor | |
Biological Process | deoxyribonucleotide biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRibonucleoside-diphosphate reductase subunit beta
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Shigella
Accessions
- Primary accessionI6DRB7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Tetramer of two alpha and two beta subunits.
Structure
Sequence
- Sequence statusComplete
- Length304
- Mass (Da)34,772
- Last updated2012-09-05 v1
- Checksum62700FE3625AE5EF
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AKNB01000271 EMBL· GenBank· DDBJ | EIQ34309.1 EMBL· GenBank· DDBJ | Genomic DNA |