I2DBZ9 · I2DBZ9_BUBBU

Function

function

Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.
Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Molecular Functionghrelin receptor binding
Molecular Functiongrowth hormone-releasing hormone activity
Biological Processgastric acid secretion
Biological Processnegative regulation of inflammatory response
Biological Processpositive regulation of growth hormone secretion
Biological Processpositive regulation of insulin secretion
Biological Processregulation of response to food

Keywords

  • Molecular function

Names & Taxonomy

Protein names

  • Recommended name
    Appetite-regulating hormone
  • Alternative names
    • Growth hormone secretagogue
    • Growth hormone-releasing peptide
    • Motilin-related peptide
  • Cleaved into 2 chains

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bubalus

Accessions

  • Primary accession
    I2DBZ9

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-18
ChainPRO_500365739919-110Appetite-regulating hormone

Post-translational modification

O-octanoylation is essential for ghrelin activity.

Keywords

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain19-45Motilin/ghrelin
Region24-56Disordered
Compositional bias27-43Basic and acidic residues
Domain51-109Motilin/ghrelin-associated peptide

Sequence similarities

Belongs to the motilin family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    110
  • Mass (Da)
    12,081
  • Last updated
    2012-07-11 v1
  • Checksum
    F787598C8EA1EC1F
TICSLLLLSVLCMDLAMAGSSFLSPEHQKLQRKEPKKPSGRLKPRALEGQFDPEVGSQMEGAEDELEIRFNAPFNIGIKLSGAQSLQHGQTLGKFLQDILLEEAEETLAD

Features

Showing features for non-terminal residue, compositional bias.

TypeIDPosition(s)Description
Non-terminal residue1
Compositional bias27-43Basic and acidic residues
Non-terminal residue110

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JQ647511
EMBL· GenBank· DDBJ
AFJ79741.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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