UniProtKB - E9Q696 (E9Q696_MOUSE)

>tr|E9Q696|E9Q696_MOUSE Tyrosine-protein kinase OS=Mus musculus OX=10090 GN=Lck PE=1 SV=1
MGASELTISGIMGCVCSSNPEDDWMENIDVCENCHYPIVPLDSKISLPIRNGSEVRDPLV
TYEGSLPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEG
FIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRD
FDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHDLVRHYTNASDGLCTKLSRPCQTQKP
QKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEA
NLMKQLQHPRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLNVNKLLDMAAQIA
EGMAFIEEQNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAP
EAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEEL
YHLMMLCWKERPEDRPTFDYLRSVLDDFFTATEGQYQPQP

Entry version 78 (07 Apr 2021)
Sequence version 1 (05 Apr 2011)
Previous versions | rss

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Protein

Tyrosine-protein kinase

Gene

Lck

Organism

Mus musculus (Mouse)

Status

Unreviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Catalytic activityⁱ

ATP
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
L-tyrosyl-[protein]
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
=
ADP
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H⁺
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
O-phospho-L-tyrosyl-[protein]
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
UniRule annotation
Automatic assertion according to rulesⁱ
- RuleBase:RU362096
ARBA annotation
Automatic assertion according to rulesⁱ
- ARBA:ARBA00001149
EC:
2.7.10.2
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
UniRule annotation
Automatic assertion according to rulesⁱ
- RuleBase:RU362096
ARBA annotation
Automatic assertion according to rulesⁱ
- ARBA:ARBA00001149
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
ATP
+
L-tyrosyl-[protein]
L-tyrosine residue
zoom
=
ADP
+
H⁺
+
O-phospho-L-tyrosyl-[protein]
L-tyrosine-phosphate residue
zoom

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	284	ATPPROSITE-ProRule annotation		1

GO - Molecular functionⁱ

ATPase binding Source: Ensembl
ATP binding Source: UniProtKB-UniRule
CD4 receptor binding Source: Ensembl
CD8 receptor binding Source: Ensembl
identical protein binding Source: Ensembl
non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
phosphatidylinositol 3-kinase binding Source: Ensembl
phosphotyrosine residue binding Source: Ensembl
protein C-terminus binding Source: Ensembl
protein kinase binding Source: Ensembl
protein phosphatase binding Source: Ensembl
protein serine/threonine phosphatase activity Source: Ensembl
SH2 domain binding Source: Ensembl
T cell receptor binding Source: Ensembl
transmembrane receptor protein tyrosine kinase activity Source: RHEA

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
cellular zinc ion homeostasis Source: Ensembl
positive regulation of heterotypic cell-cell adhesion Source: Ensembl
positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
positive regulation of T cell activation Source: Ensembl
response to drug Source: Ensembl
T cell differentiation Source: Ensembl

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Transferase, Tyrosine-protein kinaseUniRule annotationARBA annotation
Ligand	ATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesⁱ	Name:LckImported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 4

Organism-specific databases

MGIⁱ	MGI:96756, Lck

PTM / Processingⁱ

Keywords - PTMⁱ

Lipoprotein, PalmitateARBA annotation, PhosphoproteinARBA annotation

Proteomic databases

EPDⁱ	E9Q696
jPOSTⁱ	E9Q696
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	E9Q696
PeptideAtlas More...PeptideAtlasⁱ	E9Q696
PRIDEⁱ	E9Q696
ProteomicsDBⁱ	349625

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000000409, Expressed in thymus and 185 other tissues
ExpressionAtlasⁱ	E9Q696, baseline and differential
Genevisibleⁱ	E9Q696, MM

Interactionⁱ

GO - Molecular functionⁱ

ATPase binding Source: Ensembl
CD4 receptor binding Source: Ensembl
CD8 receptor binding Source: Ensembl
identical protein binding Source: Ensembl
phosphatidylinositol 3-kinase binding Source: Ensembl
phosphotyrosine residue binding Source: Ensembl
protein C-terminus binding Source: Ensembl
protein kinase binding Source: Ensembl
protein phosphatase binding Source: Ensembl
SH2 domain binding Source: Ensembl
T cell receptor binding Source: Ensembl

Complete GO annotation on QuickGO ...

Structureⁱ

3D structure databases

SMRⁱ	E9Q696
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	72 – 132	SH3InterPro annotationAdd BLAST	61
Domainⁱ	138 – 235	SH2InterPro annotationAdd BLAST	98
Domainⁱ	256 – 509	Protein kinaseInterPro annotationAdd BLAST	254

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotation

Keywords - Domainⁱ

SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000161163
Database of Orthologous Groups More...OrthoDBⁱ	539311at2759

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd10362, SH2_Src_Lck, 1 hit cd12005, SH3_Lck, 1 hit
Gene3Dⁱ	3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR011009, Kinase-like_dom_sf IPR035850, Lck_SH2 IPR035749, Lck_SH3 IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit PF00018, SH3_1, 1 hit
PRINTSⁱ	PR00401, SH2DOMAIN PR00452, SH3DOMAIN PR00109, TYRKINASE
SMARTⁱ	View protein in SMART SM00252, SH2, 1 hit SM00326, SH3, 1 hit SM00219, TyrKc, 1 hit
SUPFAMⁱ	SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit PS50002, SH3, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

E9Q696-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MGASELTISG IMGCVCSSNP EDDWMENIDV CENCHYPIVP LDSKISLPIR 
        60         70         80         90        100
NGSEVRDPLV TYEGSLPPAS PLQDNLVIAL HSYEPSHDGD LGFEKGEQLR 
       110        120        130        140        150
ILEQSGEWWK AQSLTTGQEG FIPFNFVAKA NSLEPEPWFF KNLSRKDAER 
       160        170        180        190        200
QLLAPGNTHG SFLIRESEST AGSFSLSVRD FDQNQGEVVK HYKIRNLDNG 
       210        220        230        240        250
GFYISPRITF PGLHDLVRHY TNASDGLCTK LSRPCQTQKP QKPWWEDEWE 
       260        270        280        290        300
VPRETLKLVE RLGAGQFGEV WMGYYNGHTK VAVKSLKQGS MSPDAFLAEA 
       310        320        330        340        350
NLMKQLQHPR LVRLYAVVTQ EPIYIITEYM ENGSLVDFLK TPSGIKLNVN 
       360        370        380        390        400
KLLDMAAQIA EGMAFIEEQN YIHRDLRAAN ILVSDTLSCK IADFGLARLI 
       410        420        430        440        450
EDNEYTAREG AKFPIKWTAP EAINYGTFTI KSDVWSFGIL LTEIVTHGRI 
       460        470        480        490        500
PYPGMTNPEV IQNLERGYRM VRPDNCPEEL YHLMMLCWKE RPEDRPTFDY 
       510        520
LRSVLDDFFT ATEGQYQPQP

Length:520

Mass (Da):59,003

Last modified:April 5, 2011 - v1

Checksum:ⁱ76DC69BEF5907FCC

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

P06240	LCK_MOUSE	Proto-oncogene tyrosine-protein kin... Proto-oncogene tyrosine-protein kinase LCK, EC 2.7.10.2 (Leukocyte C-terminal Src kinase, LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (p56-LCK)	Lck Lsk-t	509	Annotation score:
B2KG65	B2KG65_MOUSE	Proto-oncogene tyrosine-protein kin... Proto-oncogene tyrosine-protein kinase LCK	Lck	92	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL606921 Genomic DNA No translation available. AL671759 Genomic DNA No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_001155904.1, NM_001162432.1

Genome annotation databases

Ensemblⁱ	ENSMUST00000167288; ENSMUSP00000125777; ENSMUSG00000000409
GeneIDⁱ	16818
UCSC genome browser More...UCSCⁱ	uc012dlq.1, mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
E9Q696	Proto-oncogene tyrosine-protein kinase LCK		MOUSE		509	UniRef100_P06240
Proto-oncogene tyrosine-protein kinase LCK (Fragment)		MOUSE		92

Protein	Similar proteins		Species	Score	Length	Source
E9Q696	Proto-oncogene tyrosine-protein kinase LCK		MOUSE		509	UniRef90_P06240
Tyrosine-protein kinase Lck		AOTNA		509
Proto-oncogene tyrosine-protein kinase LCK		RAT		509
Tyrosine-protein kinase		PIG		607
Tyrosine-protein kinase		MYOBR		535
+53

Protein	Similar proteins		Species	Score	Length	Source
E9Q696	Tyrosine-protein kinase Lck	)	HUMAN		509	UniRef50_P06239
Proto-oncogene tyrosine-protein kinase LCK		CHICK		508
Tyrosine-protein kinase Lck		AOTNA		509
Proto-oncogene tyrosine-protein kinase LCK		RAT		509
Proto-oncogene tyrosine-protein kinase LCK		MOUSE		509
+677

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL606921 Genomic DNA No translation available. AL671759 Genomic DNA No translation available.
RefSeqⁱ	NP_001155904.1, NM_001162432.1

3D structure databases

SMRⁱ	E9Q696
ModBaseⁱ	Search...

Proteomic databases

EPDⁱ	E9Q696
jPOSTⁱ	E9Q696
MaxQBⁱ	E9Q696
PeptideAtlasⁱ	E9Q696
PRIDEⁱ	E9Q696
ProteomicsDBⁱ	349625

Protocols and materials databases

Antibodypediaⁱ	735, 1674 antibodies
The DNASU plasmid repository More...DNASUⁱ	16818

Genome annotation databases

Ensemblⁱ	ENSMUST00000167288; ENSMUSP00000125777; ENSMUSG00000000409
GeneIDⁱ	16818
UCSCⁱ	uc012dlq.1, mouse

Organism-specific databases

CTDⁱ	3932
MGIⁱ	MGI:96756, Lck

Phylogenomic databases

GeneTreeⁱ	ENSGT00940000161163
OrthoDBⁱ	539311at2759

Miscellaneous databases

BioGRID-ORCSⁱ	16818, 3 hits in 52 CRISPR screens
ChiTaRSⁱ	Lck, mouse
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000000409, Expressed in thymus and 185 other tissues
ExpressionAtlasⁱ	E9Q696, baseline and differential
Genevisibleⁱ	E9Q696, MM

Family and domain databases

CDDⁱ	cd10362, SH2_Src_Lck, 1 hit cd12005, SH3_Lck, 1 hit
Gene3Dⁱ	3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR011009, Kinase-like_dom_sf IPR035850, Lck_SH2 IPR035749, Lck_SH3 IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom
Pfamⁱ	View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit PF00018, SH3_1, 1 hit
PRINTSⁱ	PR00401, SH2DOMAIN PR00452, SH3DOMAIN PR00109, TYRKINASE
SMARTⁱ	View protein in SMART SM00252, SH2, 1 hit SM00326, SH3, 1 hit SM00219, TyrKc, 1 hit
SUPFAMⁱ	SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit PS50002, SH3, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	E9Q696_MOUSE
Accessionⁱ	E9Q696Primary (citable) accession number: E9Q696
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 5, 2011
	Last sequence update:	April 5, 2011
	Last modified:	April 7, 2021
	This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - E9Q696 (E9Q696_MOUSE)

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Tyrosine-protein kinase

Lck

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoplasm and Cytosol

Plasma membrane

Other locations

Cytoskeleton

Cytosol

Plasma Membrane

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ