UniProtKB - E1BKT3 (E1BKT3_BOVIN)
Protein
Submitted name:
Erbb2 interacting protein
Gene
ERBIN
Organism
Bos taurus (Bovine)
Status
Functioni
GO - Molecular functioni
- ErbB-2 class receptor binding Source: InterPro
GO - Biological processi
- cell-cell adhesion Source: GO_Central
- cellular response to tumor necrosis factor Source: Ensembl
- establishment or maintenance of epithelial cell apical/basal polarity Source: GO_Central
- negative regulation of monocyte chemotactic protein-1 production Source: Ensembl
- negative regulation of NF-kappaB transcription factor activity Source: Ensembl
- negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway Source: Ensembl
- protein targeting Source: Ensembl
- receptor clustering Source: GO_Central
- receptor localization to synapse Source: GO_Central
- regulation of postsynaptic membrane neurotransmitter receptor levels Source: Ensembl
- response to lipopolysaccharide Source: Ensembl
- response to muramyl dipeptide Source: Ensembl
- signal transduction Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Erbb2 interacting proteinImported |
Gene namesi | Name:ERBINImported |
Organismi | Bos taurus (Bovine)Imported |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:28565, ERBIN |
Subcellular locationi
Nucleus
- nuclear speck Source: Ensembl
Plasma Membrane
- basolateral plasma membrane Source: GO_Central
Other locations
- cell junction Source: GO_Central
- cytoplasm Source: Ensembl
- glutamatergic synapse Source: Ensembl
- hemidesmosome Source: Ensembl
- postsynapse Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000000415, Expressed in spleen and 18 other tissues |
ExpressionAtlasi | E1BKT3, baseline and differential |
Interactioni
GO - Molecular functioni
- ErbB-2 class receptor binding Source: InterPro
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000000533 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1369 – 1458 | PDZInterPro annotationAdd BLAST | 90 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 465 – 489 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 506 – 526 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 615 – 681 | DisorderedSequence analysisAdd BLAST | 67 | |
Regioni | 823 – 871 | DisorderedSequence analysisAdd BLAST | 49 | |
Regioni | 947 – 977 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 997 – 1021 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 1072 – 1193 | DisorderedSequence analysisAdd BLAST | 122 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 506 – 524 | PolyampholyteSequence analysisAdd BLAST | 19 | |
Compositional biasi | 631 – 645 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 646 – 681 | PolarSequence analysisAdd BLAST | 36 | |
Compositional biasi | 828 – 849 | PolyampholyteSequence analysisAdd BLAST | 22 | |
Compositional biasi | 960 – 977 | PolarSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1072 – 1094 | PolarSequence analysisAdd BLAST | 23 | |
Compositional biasi | 1143 – 1177 | PolarSequence analysisAdd BLAST | 35 |
Sequence similaritiesi
Belongs to the LAP (LRR and PDZ) protein family.ARBA annotation
Keywords - Domaini
Leucine-rich repeatARBA annotation, RepeatARBA annotationPhylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000159526 |
HOGENOMi | CLU_004220_1_0_1 |
InParanoidi | E1BKT3 |
OMAi | QVVNKDM |
OrthoDBi | 100824at2759 |
TreeFami | TF351429 |
Family and domain databases
Gene3Di | 2.30.42.10, 1 hit 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR032927, Erbin IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR001478, PDZ IPR036034, PDZ_sf |
PANTHERi | PTHR23119:SF46, PTHR23119:SF46, 1 hit |
Pfami | View protein in Pfam PF13855, LRR_8, 3 hits PF00595, PDZ, 1 hit |
SMARTi | View protein in SMART SM00369, LRR_TYP, 12 hits SM00228, PDZ, 1 hit |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 13 hits PS50106, PDZ, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
E1BKT3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTTKRSLFVR LVPCRCLRGE EETVTTLDYS HCSLEQVPKE IFTFEKTLEE
60 70 80 90 100
LYLDANQIEE LPKQLFNCQS LHKLSLPDND LTALPASIAN LINLRELDVS
110 120 130 140 150
KNGIQEFPEN IKNCKVLTVV EASVNPISKL PDGFSQLLNL TQLYLNDAFL
160 170 180 190 200
EFLPANFGRL TKLQILELRE NQLKMLPKTM NRLTQLERLD LGSNEFTEVP
210 220 230 240 250
EVLEQLSGLK EFWMDGNRLT FIPGFIGSLK QLTYLDISKN NIEMVEEGIS
260 270 280 290 300
GCENLQDLLL SSNSLQQLPE TIGSLKNVTT LKIDENQLMY LPDSIGGLVS
310 320 330 340 350
IEELDCSFNE LEALPSSIGQ LTNIRTFAAD HNYLQQLPPE IGSWKNITVL
360 370 380 390 400
FLHSNKLETL PEEMGDMQKL KVINLSDNRL KNLPFSFTKL QQLTAMWLSD
410 420 430 440 450
NQSKPLIPLQ KETDSETQKM VLTNYMFPQQ PRTEDVMFIS DNESFNPSLW
460 470 480 490 500
EEQRKQRAQV AFECDEDKDE REAPPREGNL KRYPTPYPDE LKNMVKTVQT
510 520 530 540 550
IVHRLKDEET NEDSGKDLKP HEDQQVVNND VGVKTSESIT PVRSKADERE
560 570 580 590 600
KYMIGNSIQK TSEPEAEVSS GNLPVTANVK ASENLKHIVN HDDVFEESEE
610 620 630 640 650
LSSDEEMKMA EMRPPLIETS INQPKVVALS SNKKDDTKDT DSLSDEVTHN
660 670 680 690 700
SNQNNSNCSS PSRMSDSVSL NTDSSQDTSL CSPVKQTHIG INSKIRQEDE
710 720 730 740 750
NFNSLLQNGD ILNHSTEEKI KVPDKKDFNL PEYDLNIEER LVLIEKGVDS
760 770 780 790 800
TATSDESHKL DHINMNLNKL VTNDTFQPEI VERSKTQDTA LGMGFLSNNA
810 820 830 840 850
KGEAEHLENG NKFPNVECIN KVNGHSEETP QSPRRTEPHD TDSSVDVGHS
860 870 880 890 900
KSTEDLSPQK SGPIGPVVKS HSITNMETGG LKIYDILSDN GPQQPSATAK
910 920 930 940 950
VTSTIDGKNI VRSKSATLLY DQPLQVFTGS SSSSDLISGA KAIFKFDSNH
960 970 980 990 1000
NPEEPHIRGP TTSGPQSVPQ MYGPPQYNIQ YSGSAAVKDT LWHSKQNPQV
1010 1020 1030 1040 1050
DPVSFPSQRF PRSESTESHS YAKHSANMNF SNHNNVRANT GYHLHQRLGP
1060 1070 1080 1090 1100
GRHGDMWAIS PNDRLIPGAT RTTIQRQSSV SSAASVNLGE PGSTRRTQVP
1110 1120 1130 1140 1150
EGDYLSYREL HSVGRTPPMM SGSQRPLSAR TYSVDGPHAS RPQSARPSVS
1160 1170 1180 1190 1200
EIPERTMSVS DFSYSRTSPS KRPNTRVGSE HSLLDPPGKS KVPHDWREQV
1210 1220 1230 1240 1250
LRHIEAKKLE KSMLSRSFNS NFTAVSNFHY GSSRDLHGSQ GSLALSVADG
1260 1270 1280 1290 1300
RGSGGHTFRH PQTSCPGDPC QDDIFISGQQ NYPSATLSHK DVLPDSLMKM
1310 1320 1330 1340 1350
PLSNGQMGQP LRPQANYSQI HHPLPQASVA RHPSREQLID YLMLKVAHQP
1360 1370 1380 1390 1400
PYTQPHCSPR QGHELARQEI RVRVEKDPEL GFSISGGVGG RGNPFRPDDD
1410 1420 1430 1440 1450
GIFVTRVQPE GPASKLLQPG DKIIQANGYS FINIEHGQAV SLLKTFQNTV
1460
ELIILREVSS
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q1LS66 | A0A3Q1LS66_BOVIN | Erbb2 interacting protein | ERBIN | 1,372 | Annotation score: | ||
A0A3Q1N2M4 | A0A3Q1N2M4_BOVIN | Erbb2 interacting protein | ERBIN | 1,302 | Annotation score: | ||
A0A3Q1M9R3 | A0A3Q1M9R3_BOVIN | Erbb2 interacting protein | ERBIN | 1,412 | Annotation score: | ||
A0A3Q1NDG8 | A0A3Q1NDG8_BOVIN | Erbb2 interacting protein | ERBIN | 1,420 | Annotation score: | ||
A0A3Q1M8M4 | A0A3Q1M8M4_BOVIN | Erbb2 interacting protein | ERBIN | 1,390 | Annotation score: | ||
A0A3Q1MSP5 | A0A3Q1MSP5_BOVIN | Erbb2 interacting protein | ERBIN | 1,350 | Annotation score: |
Sequence databases
RefSeqi | XP_005221508.1, XM_005221451.3 |
Genome annotation databases
Ensembli | ENSBTAT00000000533; ENSBTAP00000000533; ENSBTAG00000000415 |
GeneIDi | 512866 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_005221508.1, XM_005221451.3 |
3D structure databases
SMRi | E1BKT3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000000533 |
Proteomic databases
PaxDbi | E1BKT3 |
PRIDEi | E1BKT3 |
Genome annotation databases
Ensembli | ENSBTAT00000000533; ENSBTAP00000000533; ENSBTAG00000000415 |
GeneIDi | 512866 |
Organism-specific databases
CTDi | 55914 |
VGNCi | VGNC:28565, ERBIN |
Phylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000159526 |
HOGENOMi | CLU_004220_1_0_1 |
InParanoidi | E1BKT3 |
OMAi | QVVNKDM |
OrthoDBi | 100824at2759 |
TreeFami | TF351429 |
Gene expression databases
Bgeei | ENSBTAG00000000415, Expressed in spleen and 18 other tissues |
ExpressionAtlasi | E1BKT3, baseline and differential |
Family and domain databases
Gene3Di | 2.30.42.10, 1 hit 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR032927, Erbin IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR001478, PDZ IPR036034, PDZ_sf |
PANTHERi | PTHR23119:SF46, PTHR23119:SF46, 1 hit |
Pfami | View protein in Pfam PF13855, LRR_8, 3 hits PF00595, PDZ, 1 hit |
SMARTi | View protein in SMART SM00369, LRR_TYP, 12 hits SM00228, PDZ, 1 hit |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 13 hits PS50106, PDZ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E1BKT3_BOVIN | |
Accessioni | E1BKT3Primary (citable) accession number: E1BKT3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 2, 2010 |
Last sequence update: | November 16, 2011 | |
Last modified: | February 10, 2021 | |
This is version 74 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |