D3VVK7 · D3VVK7_HUMAN

  • Protein
    ubiquitinyl hydrolase 1
  • Gene
    ATXN3
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    2/5

Function

Catalytic activity

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
    EC:3.4.19.12 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

139550100150200250300350
TypeIDPosition(s)Description
Active site14
Active site14Nucleophile
Active site119
Active site119Proton acceptor
Active site134

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular Functioncysteine-type deubiquitinase activity
Biological Processprotein deubiquitination
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    ubiquitinyl hydrolase 1
  • EC number

Gene names

    • Name
      ATXN3

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    D3VVK7

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Proteomic databases

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain1-180Josephin
Region366-395Disordered

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    395
  • Mass (Da)
    46,347
  • Last updated
    2010-04-20 v1
  • Checksum
    CA4C149A3B9EE94F
MESIFHEKQEGSLCAQHCLNNLLQGEYFSPVELSTIAHQLDEEERMRMAEGGVTSEDYRTFLQQPSGNMDDSGFFSIQVISNALKVWGLELILFNSPEYQRLRIDPINERSFICNYKEHWFTVRKLGKQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERMLEANDGSGMLDEDEEDLQRALALSRQEIDMGDEEADLRRAIQLSMQGISRDISQDMTQTLGTNLTSEKLRKRREAYFEKQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQRDLSGQSSHPCERPATSSGALGSD

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue395

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GQ176686
EMBL· GenBank· DDBJ
ADD00735.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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