B9K6S9 · DISA_THENN

Function

function

Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions.
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site71ATP (UniProtKB | ChEBI)
Binding site89ATP (UniProtKB | ChEBI)
Binding site102-106ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular Functiondiadenylate cyclase activity
Molecular FunctionDNA binding
Biological ProcessDNA repair

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    DNA integrity scanning protein DisA
  • Alternative names
    • Cyclic di-AMP synthase
      (c-di-AMP synthase
      )
    • Diadenylate cyclase
      (EC:2.7.7.85
      ) . EC:2.7.7.85 (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      disA
    • Ordered locus names
      CTN_0486

Organism names

Accessions

  • Primary accession
    B9K6S9

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10001849131-352DNA integrity scanning protein DisA

Interaction

Subunit

Homooctamer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-143DAC

Sequence similarities

Belongs to the DisA family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    352
  • Mass (Da)
    39,966
  • Last updated
    2009-03-24 v1
  • Checksum
    FAC8B3EA6E8B0F29
MVPQELIEKIKLISPGTELRKALDDIISANFGALIFLVDDPKKYDDIIQGGFWLDTDFSAEKVYELSKMDGAIVLSEDLTRIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSRRRNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFDKLLSDLEVLELENRVTLADVVRTLMKGVELLRITEETRPYIVELGEEGRLARMQLRELTEDVDDLMVLLIMDYSSDEVDEETAQAILQDFVTRREPSPISISRVLGYDVQQVSQLDDILVSARGYRLLKTAARIPISIGYNVVKMFKTLDQISKASVEDLKKVEGIGEKRAKAISESISSLKHRRTSE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000916
EMBL· GenBank· DDBJ
ACM22662.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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