B9K6S9 · DISA_THENN
- ProteinDNA integrity scanning protein DisA
- GenedisA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids352 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions.
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.
Catalytic activity
- 2 ATP = 3',3'-c-di-AMP + 2 diphosphate
Cofactor
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | diadenylate cyclase activity | |
Molecular Function | DNA binding | |
Biological Process | DNA repair |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameDNA integrity scanning protein DisA
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Thermotogota > Thermotogae > Thermotogales > Thermotogaceae > Thermotoga
Accessions
- Primary accessionB9K6S9
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000184913 | 1-352 | DNA integrity scanning protein DisA | |||
Sequence: MVPQELIEKIKLISPGTELRKALDDIISANFGALIFLVDDPKKYDDIIQGGFWLDTDFSAEKVYELSKMDGAIVLSEDLTRIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSRRRNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFDKLLSDLEVLELENRVTLADVVRTLMKGVELLRITEETRPYIVELGEEGRLARMQLRELTEDVDDLMVLLIMDYSSDEVDEETAQAILQDFVTRREPSPISISRVLGYDVQQVSQLDDILVSARGYRLLKTAARIPISIGYNVVKMFKTLDQISKASVEDLKKVEGIGEKRAKAISESISSLKHRRTSE |
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 3-143 | DAC | ||||
Sequence: PQELIEKIKLISPGTELRKALDDIISANFGALIFLVDDPKKYDDIIQGGFWLDTDFSAEKVYELSKMDGAIVLSEDLTRIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSRRRNIISLYYKNYKYVVNQVD |
Sequence similarities
Belongs to the DisA family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length352
- Mass (Da)39,966
- Last updated2009-03-24 v1
- ChecksumFAC8B3EA6E8B0F29
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000916 EMBL· GenBank· DDBJ | ACM22662.1 EMBL· GenBank· DDBJ | Genomic DNA |